6,067 research outputs found
Cancer Immunotherapy of TLR4 Agonist-Antigen Constructs Enhanced with Pathogen-Mimicking Magnetite Nanoparticles and Checkpoint Blockade of PD-L1
No full textDespite the tremendous potential of Toll-like receptor 4 (TLR4) agonists in vaccines, their efficacy as monotherapy to treat cancer has been limited. Only some lipopolysaccharides (LPS) isolated from particular bacterial strains or structures like monophosphoryl lipid A (MPLA) derived from lipooligosaccharide (LOS), avoid toxic overactivation of innate immune responses while retaining adequate immunogenicity to act as adjuvants. Here, different LOS structures are incorporated into nanoparticle-filled phospholipid micelles for efficient vaccine delivery and more potent cancer immunotherapy. The structurally unique LOS of the plant pathogen Xcc is incorporated into phospholipid micelles encapsulating iron oxide nanoparticles, producing stable pathogen-mimicking nanostructures suitable for targeting antigen presenting cells in the lymph nodes. The antigen is conjugated via a hydrazone bond, enabling rapid, easy-to-monitor and high-yield antigen ligation at low concentrations. The protective effect of these constructs is investigated against a highly aggressive model for tumor immunotherapy. The results show that the nanovaccines lead to a higher-level antigen-specific cytotoxic T lymphocyte (CTL) effector and memory responses, which when combined with abrogation of the immunosuppressive programmed death-ligand 1 (PD-L1), provide 100% long-term protection against repeated tumor challenge. This nanovaccine platform in combination with checkpoint inhibition of PD-L1 represents a promising approach to improve the cancer immunotherapy of TLR4 agonists
Effective binding and sensing of lipopolysaccharide: combining complementary pattern recognition receptors
No full textEl Tlacuache Núm. 301 (2008). 301 Año 9 (2008) marzo. El Tlacuache
No full textLos ojos de la Noche Triste de Margarita González Saravia Calderón por Marco Antonio Santos Ramírez. - Democracia sin democratas y otras invenciones por Gilberto López y Rivas. - Conjunto Monacal de San Juan Bautista, Tlayacapan por Teresita Loera Cabeza de Vaca, Gabriela Caballero
Small molecule activation using electropositive metal N-heterocyclic carbene complexes
No full textThe versatility of N-heterocyclic carbenes (NHCs) is demonstrated by numerous
practical applications in homogeneous transition metal catalysis, organocatalysis and
materials science. There remains a paucity of electropositive metal NHC complexes and so
this chemistry is poorly developed with respect to that of the late transition metal and main
group elements. This thesis describes the synthesis of new alkoxy-tethered NHC proligands,
their use in the synthesis of reactive metal amide and metal alkyl complexes, and finally
small molecule activation using these complexes.
Chapter One introduces NHCs and discusses their use as supporting ligands for early
transition metal and f-block complexes. Small molecule activation using organometallic
complexes is examined alongside the use of electropositive metal NHC complexes in
catalysis.
Chapter Two contains the synthesis and characterisation of new alkoxy-tethered
NHC proligands and a variety of electropositive MII (M = Mg and Zn), MIII (M = Y, Sc, Ce
and U) and MIV (M = Ce and U) amide complexes. X-ray diffraction studies and a DFT
study are used to probe the extent of covalency in the bonding of the MIV complexes.
Chapter Three investigates the reactivity of the amide complexes prepared in
Chapter Two. The MII
complexes are shown to be initiators for the polymerisation of raclactide
into biodegradable polymers. The MIII complexes are used to demonstrate additionelimination
reactivity of polar substrates across the M-Ccarbene bond which allows the
formation of new N-E (E = Si, Sn, P or B) bonds. Treatment of the UIII silylamide complex
U(N{SiMe3}2)3 with CO results in the reductive coupling and homologation of CO to form
an ynediolate core -OC≡CO- and the first example of subsequent reactivity of the ynediolate
group. The MIV complexes are used to examine the potential for forming MIV cationic
species and alkyl complexes.
Chapter Four examines the synthesis of MIII (M = Ce and Sc) aminobenzyl
complexes and MIII (M = Y, Sc and U) neosilyl and neopentyl alkyl complexes. The
addition-elimination reactivity discussed in Chapter Three is extended to include C-E bond
formation (E = Si, Sn, P, B, I or C).
Chapter Five provides overall conclusions to the work presented within this thesis.
Chapter Six gives experimental and characterising data for all complexes and
reactions in this work
ChemInform Abstract: Cooperation of Metals and Hydrogen Bonding Groups in Metal‐Promoted Reactions
No full textFLAMENCO / ANGELILLO de VALLADOLID. à la guitare : JUAN SOTO
No full textComprend : LA HIJA DE DON JUAN ALBA / L. RIVAS GOMEZ, F. INFANTES FLORIDO - ANTONIO VARGAS / LEON QUIROGA - FANDANGO DE SEVILLA / ANTONIO SEVILLIANO-Folklore - ALEGRIAS / R. MONTES - SEMANA SANTA EN SEVILLA / Folklore - EL EMIGRANTE / J. VALDERRAMA, M. SERRAPI, M. PITTO - FANDANGO POR SOLEARES : Folklore - HIJA DE JUAN SIMON / C. CAMPS, M. TORRES, D. MONTERIO - QUE MALA ERES BULERIA / LEON QUIROGA - MEDIA GRANADINA / FolkloreBnF-Partenariats, Collection sonore - BelieveContient une table des matière
ChemInform Abstract: Hydrogen Bonding in Substituted-Ammonium Salts of the Tetracarbonylcobaltate(-I) Anion: Some Insights into Potential Roles for Transition Metals in Organometallic Crystal Engineering
No full textContributions to the Knowledge of Sexual Dimorphism in Liolaemus darwinii (Squamata, Liolaemidae) in the Monte Desert of Argentina
No full textThe lizard Liolaemus darwinii (Liolaemidae) is a typical species with wide distribution in Monte environments of Argentina. The objective of this study is contribute to knowledge of sexual dimorphism in a population of L. darwinii (Bell, 1843). We evaluated sexual shape variation of the cephalic region through procustes analyses with geometric morphometry. We predict that the heads in males will have diff erences in shape with respect to females. The results showed signifi cant sexual diff erences in shape, mainly in the region around the eyes. There were no signifi cant differences in sizes. Geometric morphometry analyses are a useful tool for addressing sexual differences in Monte lizards. This constitutes the first study for the center-west of Argentina in San Juan province that implements these geometric morphometry analyses.Fil: Castillo, Gabriel Natalio. Universidad Nacional de San Juan. Facultad de Ciencias Exactas Físicas y Naturales. Departamento de Biología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; ArgentinaFil: González Rivas, Cynthia Jesica. Centro de Rehabilitación de Fauna Silvestre, Educación Ambiental y Recreación Responsable; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Acosta, Juan Carlos. Universidad Nacional de San Juan. Facultad de Ciencias Exactas Físicas y Naturales. Departamento de Biología; Argentin
ChemInform Abstract: The Combination of Transition Metal Ions and Hydrogen‐Bonding Interactions
No full textPleurodema nebulosum (Mendoza Four-eyed Frog). Endoparasites
No full textPleurodema nebulosum occurs in several provinces of Argentina in the dry Chaco and Monte ecoregions (Vaira et al. 2012. Cuad. Herpetol. 26:131–159). We examined the body cavity of 38 adult P. nebulosum (45 mm mean SVL) collected over three years (2017–2019) in Presidente Sarmiento Provincial Park in San Juan Province, Argentina and deposited in the herpetology collection of the Universidad Nacional de San Juan as (UNSJ 4076-4096). The body cavity was opened by a mid-ventral incision and the interior was searched for helminths utilizing a dissecting microscope. Ten cestodes were found in the stomachs of two individuals. The cestodes were placed in hot distilled water to relax them and subsequently fixed in 10% formalin. They were then stained with hydrochloric carmine, dehydrated, and mounted on slides containing Canada balsam. They were examined with a light microscope and identified as Cylindrotaenia sp., similar to C. americana (Cyclophillidea: Nematotaenidae) (Jewell 1916. J. Parasitol. 2:181–192). The specimens were deposited in the parasitological collection of the Department of Biology, National University of San Juan (UNSJPar 282). They exhibited the following characteristics: paruterine capsules not surrounded by membranes and paruterine organs surrounded by growing cells. Infection prevalence was 5.26%; mean intensity was 5 ± 1.41 SD, range: 4–6 and mean abundance was 0.26. In Argentina, there is only one report of Cylindrotaenia sp. as a parasite; parasitizing Rhinella major in Formosa province, Argentina (Hamann and González 2015. Acta Herpetol. 10:9–101). In this note, the distribution of Cylindrotaenia sp. is expanded and P. nebulosum is a new host record for C. cf. americana.Fil: Castillo, Gabriel Natalio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Centro de Investigaciones de la Geosfera y Biosfera. Universidad Nacional de San Juan. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones de la Geosfera y Biosfera; ArgentinaFil: González Rivas, Cynthia Jesica. Universidad Nacional de San Juan. Facultad de Ciencias Exactas Físicas y Naturales. Departamento de Biología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; ArgentinaFil: Acosta, Juan Carlos. Universidad Nacional de San Juan. Facultad de Ciencias Exactas Físicas y Naturales. Departamento de Biología; Argentin
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