1,722,270 research outputs found
Coma, alterazioni della coscienza e sonno
No full textComa - Stato simile al sonno di protratta non responsività dal quale il paziente non può essere risvegliato con appropriati stimoli sensoriali.
- E’ la conseguenza di un insulto che interessa in maniera estesa gli emisferi cerebrali e/o la sostanza reticolare attivante.
- Le cause del coma sono ascrivibili a problemi di tipo strutturale (traumi, lesioni occupanti spazio, ischemia ed emorragia cerebrale) o non strutturale (cause infettivo-infiammatorie delle meningi e dell’encefalo, encefalopatie tossico-metaboliche, anossia).
- Tra un individuo in pieno stato di coscienza ed un paziente in coma profondo esiste un continuum di condizioni nelle quali può essere maggiormente compromesso lo stato di vigilanza, ossia il livello di coscienza piuttosto che il suo contenuto o viceversa
Flexibility of the Levallois Concept in the Italian Late Middle Palaeolithic. A view from the Oscurusciuto rockshelter
No full textThis monograph investigates Neanderthal stone tool production variations through an integrated study of lithic assemblages from the Mousterian phase at the Oscurusciuto rock shelter in southern Italy. Concentrating on four critical occupational levels (SU 15, SU 14, SU 13, and SU 11), it provides a diachronic perspective, uncovering the evolution of lithic production strategies over time. This approach allows for a thorough examination of lithic production method diversity, debitage concepts, and their relationship to raw materials and cultural traditions. The study particularly emphasises Levallois debitage and its applications at the site, discussing identification criteria and adaptability. It highlights the distinctiveness of lithic toolmaking from this significant phase of the Late Middle Palaeolithic in Europe
Technological behavior of the last Neanderthal and first Sapiens in Italy
Full text linkThis research investigates the technological evolution during the Middle to Upper Paleolithic transition, focusing on comparing stone tool technologies of Neanderthals and early modern humans in Italy. The study addresses the challenge of comparing diverse artifact datasets using cognigrams, a method developed for coding and analyzing tool-making behaviors. By applying cognigrams to key Italian sites - Oscurusciuto (Neanderthals) and Castelcivita (sapiens), the research decodes the Levallois and Uluzzian reduction sequences, examining raw material acquisition, core reduction, and anvil preparation. The comparison aims to understand the different technological complexities and cognitive capacities of both species, offering insights into the evolutionary success of Homo sapiens
¿Quién diseña las ciudades?
Full text linkTrabajo presentado en el Call for Posters. Habitat III. Quito, Ecuador. 2016Fil: Marciani, Florencia. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Moisset, Inés. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaLa historia de las arquitectas no ha sido contada de igual manera que la de sus colegas varones debido a que la escala de valores con la que se ha construido la historia ha estado sesgada por la mirada desde una experiencia, por lo tanto, D IAG R AM A D E todo aquello que no entre en esa perspectiva queda desconocido, negado y olvidado. Esta valoración sesgada es extensiva a las historias de todos los otros o subalternos, es decir, las minorías étnicas o de otro tipo, los no blancos, los no*https://www.researchgate.net/publication/328918621_AGENDA_GLOBAL_ACCIONES_LOCALES_CALL_FOR_POSTERSFil: Marciani, Florencia. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Moisset, Inés. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaOtras Humanidade
Phlebographic Study between Patients with MS and Control Subjects: The Ethical Profile.
Full text linkCALORIMETRIA DIFFERENZIALE A SCANSIONE DI MISCELE FOSFOLIPIDICHE DA MEMBRANE DI GLOBULI ROSSI
No full textNegli ultimi anni particolare attenzione è stata posta alle relazioni tra funzione delle membrane, le loro proprietà chimico-fisiche e la composizione in acidi grassi, prevalentemente della frazione fosfolipidica considerato il fatto che fosfolipidi, trovati nelle membrane biologiche, derivano le loro proprietà idrofobiche dagli acidi grassi costituenti.
Le correlazioni più frequentemente analizzate sono quelle tra componenti di membrana e i loro acidi grassi modificati, in vivo, da alterazioni della composizione lipidica della dieta o, in vitro, mediante opportune modifiche del mezzo di coltura.
Somministrando diete diverse a bovine da latte abbiamo creato una “banca” di campioni di membrane di globuli rossi a diversa composizione lipidica (1, 2).
Scopi di questo studio sono stati: 1) l’analisi della composizione delle miscele di fosfolipidi estratti dalle membrane, 2) la valutazione delle correlazioni tra composizione e proprietà termotropiche delle miscele.
I lipidi totali sono stati estratti dagli eritrociti bovini con miscele di cloroformio/metanolo in diversi rapporti e le miscele lipidiche sono state frazionate mediante cromatografia su colonna.
Le singole specie fosfolipidiche sono state separate in HPTLC e quantificate mediante densitometria a scansione.
La composizione in acidi grassi dei fosfolipidi di membrana è stata valutata mediante gas-liquido cromatografia e dispersioni acquose tamponate sono state esaminate mediante calorimetria differenziale a scansione.
Per ogni campione è stato calcolato il contenuto di acidi grassi saturi (S), insaturi (U) e l’indice di insaturazione (UI).
I principali acidi grassi presenti (mediamente ≥ 10% in peso) sono risultati: C16:0, C18:0, C18:1, C18:2 e C24:0.
Le miscele di fosfolipi mostrano una o due transizioni di fase a temperature comprese tra 17.7 e 40.0 °C. La prima temperatura di transizione è compresa tra 17.7 e 26.0 °C.
UI e U/S non risultano essere correlati al contenuto percentuale delle diverse specie molecolari di fosfolipidi (PC, PE, SM, PS+PI) e di PC+SM, costituenti principali del foglietto esterno del doppio strato lipidico.
Esiste, invece, una correlazione lineare tra la prima temperatura di transizione ed UI (P < 0.05) e U/S (P < 0.01). La prima temperatura di transizione diminuisce all’aumentare di UI o del rapporto U/S.
References
1. G. Monticelli, S. Rapelli, G. Montorfano, P. Magistretti and B. Berra- “Red blood cell membrane composition following diet manipulation in the cow” Riv. Ital. Sostanze Grasse 67: 507-515 (1990)
2. G. Monticelli, M. Masserini,G. Lercker, T. Beringhelli, P. Marciani, E. Calappi and B. Berra – “Red blood cell membrane composition following diet manipulation in the cow. II: phospholipid fatty acid distribution and physico-chemical characteristics of membrane and its constituents” Riv. Ital. Sostanze Grasse 69: 189-199 (1992
MRI of the colon in the pharmaceutical field: the future before us
Full text linkOral solid drug formulation is the most common route for administration and it is vital to increase knowledge of the gastrointestinal physiological environment to understand dissolution and absorption processes and to develop reliable biorelevant in vitro tools. In particular, colon targeted drug formulations have raised the attention of pharmaceutical scientists because of the great potential of colonic drug delivery. However the distal bowel is still a relatively understudied part of the gastrointestinal tract. Recently, Magnetic Resonance Imaging (MRI) has been gaining an emerging role in studying the colon. This article provides a comprehensive, contemporary review of the literature on luminal MRI of the colonic environment of the last 15 years with specific focus on colon physiological dimensions, motility, chyme and fluids, transit and luminal flow. The work reviewed provides novel physiological insight that will have a profound impact on our understanding of the colonic environment for drug delivery and absorption and will ultimately help to raise the in vitro / in vivo relevance of computer simulations and bench models
Corrado Marciani. Lettres de change aux foires de Lanciano au XVIe siècle.
No full textFavier Jean. Corrado Marciani. Lettres de change aux foires de Lanciano au XVIe siècle.. In: Journal des savants, 1965, n°2. pp. 540-541
Inhibition of anion transport in human red blood cell : effect on the electrophoretic velocity
No full textThe electrophoretic mobility exhibited by the human red blood cells (RBC), under electric field, depends on: 1) the intensity of the applied electric field, 2) the shape and the net surface charge density of the cell, 3) the characteristics of the suspending medium (pH, ionic strength, viscosity and osmolarity).
Negative cell surface charge is due to both membrane glycolipids and glycoproteins.
We studied the influence of some inhibitors of anion exchange [phenylglyoxal (PG) and three PG derivatives: 4-hydroxy-3-nitrophenylglyoxal (HNPG), 3-methoxyphenylglyoxal (3MOPG) and 4-methoxyphenylgyoxal (4MOPG)] on electrophoretic mobility.
The experiments were performed in an horizontal cylindrical capillary by the microscope method at room temperature and physiological pH; the ionic strength was 0.262 mol/l.
After treatment with the inhibitors RBCs showed a reduced electrophoretic mobility: -16.7% by PG (5 mM), -14.7, -17.6% and -18.4% by HNPG (2 mM), 3MOPG(2mM) and 4MOPG (10 mM).
The surface electrical charge density was calculated by two models: assuming the RBC to be spherical or using a flat plate model. All inhibitors reduced the surface electrical charge density: -18.7 and -21.2 by PG, -14.6 and -16.9 by HNPG, -16.9 and -19.2 by 3MOPG, -19.4 and -21.8 by 4MOPG respectively.
The major role of inhibitors probably lies in their capability to react with arginine of Band 3 masking the glycoprotein charges and thus reducing the negative surface electrical charge.
In agreement with the characteristics of the inhibitory action on the anion exchange, we found a completely reversible HNPG reduction of electrophoretic mobility while it was not the case for PG, 3MOPG and 4MOPG reduction
EFFECTS OF HYPERTONIC SOLUTIONS AND OF SOME ANION TRANSPORT INHIBITORS ON THE ELECTROPHORETIC MOBILITY OF HUMAN ERYTHROCYTES
No full textUnder the conditions of physiological pH and ionic strength, the human erythrocytes exhibit a negative electrophoretic mobility (EM) due to the negative surface charge. In this research we studied the effects on the EM of: 1) the hypertonicity of the suspending medium, 2) the inhibition of anion exchange by means of some powerful molecules (phenylglyoxal, PG and two PG derivatives: HNPG and 3-MOPG kindly given by L. Zaki, Frankfurt). The experiments were performed in a horizontal cylindrical capillary by the microscope method at room temperature. In all the experiments the erythrocyte migration velocity resulted linearly related to the applied electric field (0-15 V/cm). In isotonic solution a mean velocity (± SE) of 1.47±0.04 (n=14) μm/s V/cm was obtained. The red blood cells suspended in hypertonic medium (400 mOsm) reduced their EM of about 16.2%. The incubation (30 min) of erythrocytes in solution containing PG (5mM), HNPG (2 mM) or 3-MOPG reduced EM respectively about 16.5%, 11.5% and 13.5%. HNPG reduction was reversible, those caused by PG and 3-MOPG were not. For the inhibitors the major role possibly lies in their ability to reduce the negative surface charge interacting with transport systems. For the hypertonic solution we must take into account the changes of size and shape which might mask partially the electrical charges for a new make up of the membrane surfac
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