992 research outputs found
Colors 1981
No full textCONTENTS
Untitled, John I. C. Ramirez 2;
Love will fly, Tim Furness 3;
Untitled, Palmer Hoovestal 4;
The wave, Jerome Lightbourne 6;
The land*lord, R. Lea 7;
Song of the newborn, Heidi Muller 8;
Untitled, Mary Ostervold 9;
Good crops, Gina Larson 10;
Come, challenge the sea, Paula Schafer 12;
Untitled, Pat Dooris 14;
Untitled, Eric Peterson 16;
A flight of fancy, Tony Schaan 17;
Ode upon a london tube, Kit Warfield 18;
Sponge, Debbie Court 19;
Untitled, Debbie Court 20;
Untitled, John I. C. Ramirez 21;
Untitled, Joyce Lowry 21;
Untitled, Mary Taft 22;
Thank you, Lord [unidentified author] 23;
From generation to generation, Denise Marsh 24;
Untitled, S. M. 25;
Untitled, M. F. 26;
Brain Cramp, Francine Bergeron 27;
Untitled, Pat Dooris 28;
Untitled, Tom Mertes 30;
Untitled, John I. C. Ramirez 31;
Untitled, Dolores Bock 31;
Untitled, Christopher Perez 32;
Untitled, Pat Dooris 33;
Echoes of Innocence, Kelly Cosgrove 35;
Beloved, M. Bowen 36;
Untitled, Mary Ostervold 36
Unveiling the role of EVs in anaerobic parasitic protozoa
No full textThe anaerobic or microaerophilic protozoan parasites such as the enteric human pathogens Entamoeba histolytica, Giardia intestinalis, Cryptosporidium parvum, Blastocystis hominis and urogenital tract parasites Trichomonas vaginalis are able to survival in an environment with oxygen deprivation. Despite living in hostile environments these pathogens adopted different strategies to survive within the hosts. Among them, the release of extracellular vesicles (EVs) has become an active endeavor in the study of pathogenesis for these parasites. EVs are heterogenous, membrane-limited structures that have played important roles in cellular communication, transferring information through cargo and modulating the immune system of the host. In this review, we described several aspects of the recently characterized EVs of the anaerobic protozoa, including their role in adhesion, modulation of the immune response and omics analysis to understand the potential of these EVs in the pathogenesis of these diseases caused by anaerobic parasites.Fil: Sabatke, Bruna. Universidade Federal do Paraná; BrasilFil: Gavinho, Bruno. Universidade Federal do Paraná; BrasilFil: Cóceres, Verónica Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: de Miguel, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Ramirez, Marcel I.. Universidade Federal do Paraná; Brasil. Fundación Oswaldo Cruz; Brasi
On the taxonomic status of Liolaemus filiorum Pincheira-Donoso & Ramirez, 2005 (Iguania: Liolaemidae): A response to Pincheira-Donoso
No full textArtículo de publicación ISII discuss the arguments put forth recently by Pincheira-Donoso, in which the author attempts to revalidate Liolaemus filiorum Pincheira-Donoso & Ramirez, 2005, a species which I had previously considered a junior synonym of L. puritamensis. The author of this revalidation omitted important information including: 1) the description was published without peer review, 2) one of the two types was deposited in a personal collection, 3) the diagnosis is weak and unclear, 4) the holotype was not explicitly described or illustrated. Additionally, the author did not discuss key aspects of my paper, most particularly, the incorrect designation of the holotype of L. filiorum
Impacts of defossilising downstream derivatives in petrochemical clusters – MTBE case study
No full textUsing alternative carbon sources (ACS) to produce downstream derivatives (DDs) is a promising option for defossilising the chemical industry. However, the potential consequences of using ACS in interconnected petrochemical clusters are generally overlooked. This paper aims to develop a methodological approach for systematically analysing defossilisation impacts at the value chain level. For this, a single value chain for producing methyl-tert-butyl-ether (MTBE) was used as a case study. The individual components of the value chain were modelled in Aspen Plus v12. Both ACS- and fossil-based value chains were compared in terms of (i) changes in the structure of the value chain and (ii) the magnitude of the impacts. The results show that the defossilisation of a single value chain causes additional impacts at the cluster level.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Energy and Industr
Flora mexicana,
No full text"Reseña de la expedición de historia natural dirigida por Martin Sessé" [by Ricardo Ramirez]: p. [iii]-xi.Issued in 10 pt., 1891-97, as appendix to La Naturaleza, ser. II, v. 2.Mode of access: Internet
Effect of the degree of polymerization of polyglycerol on the emulsifying capacity of polyglycerols ester of saturated carboxylic acids of different lengths of carboned chain*
No full textLa creciente oferta de glicerol crudo proveniente de la industria del biodiesel ha reducido drásticamente su valor comercial. Como una opción para afrontar esta problemática esta la síntesis de productos de valor agregado tales como los poligliceroles éster de ácidos carboxílicos, los cuales son polímeros versátiles que presentan buen desempeño como emulsificantes no-iónicos. En el presente trabajo se estudió el efecto del grado de polimerización de poliglicerol y la longitud de la cadena carbonada de los ácidos carboxílicos saturados utilizados en la síntesis de poliglicerol éster sobre su capacidad emulsificante. Debido a que las moléculas de emulsificante sintetizadas deben poseer una zona hidrófila y otra lipófila, el estudio se dividió en tres temas; en el primero se abordan la formación de la zona hidrófila, en el segundo se describen los conceptos de la formación de la zona lipófila y el tercer tema se dedicó a evaluar los emulsificantes sintetizados. En el Tema I se analizó la etapa de polimerización utilizando ácido sulfúrico e hidróxido de sodio como catalizadores. Se estimaron los parámetros cinéticos a través de análisis termogravimétrico TGA y calorimetría diferencial de barrido DSC. Posteriormente los parámetros cinéticos estimados fueron validados usando métodos de titulación, FTIR y espectrometría de masas. En el Tema II se realizaron diseños experimentales variando el tiempo de reacción y la longitud de la cadena del ácido carboxílico para evaluar su efecto sobre la síntesis de poligliceroles éster; se trabajó con ácidos saturados para no tener la perturbación adicional de otros grupos funcionales. En el Tema III se evaluó el efecto del grado de polimerización y longitud de la cadena carbonada del ácido carboxílico sobre la capacidad emulsificante del poliglicerol éster sintetizado, para lo cual se utilizaron técnicas de microscopia óptica, tensión superficial y tiempo de estabilidad de las emulsiones.MaestríaMagíster en Ingeniería QuímicaThe growing supply of crude glycerol from the biodiesel industry has drastically reduced its commercial value. One of the options to address this problem is the synthesis of value-added product such as polyglycerol ester of carboxylic acids, wich are versatile polymers that can present a good performance as nonionic emulsifiers. In this work, the effect of degree of polymerization of polyglycerol and the length of the carbon chain of the saturated carboxylic acids used in the synthesis of polyglycerol ester on their emulsifying capacity was studied. Because the emulsifier molecules synthesized must possess a hydrophilic and a lipophilic zone, the study was divided into three topics; in the first, the formation of the hydrophilic zone is analyzed, in the second, the concepts of the lipophilic zone formation was described and the third topic was devoted to the evaluation of the synthesized emulsifiers. In topic I polymerization step was studied using sulfuric acid and sodium hydroxide as catalysts. Kinetic parameters were estimated by thermogravimetric analysis and differential scanning calorimetry. Subsequently the estimated parameters were validated with reaction monitoring using titration methods, FTIR and mass spectrometry. In topic II experimental designs were made varying the reaction time and the length of the carboxylic acid chain to evaluate their effect on the synthesis of polyglycerol ester; The author worked with saturated acids to avoid additional disturbance of other functional groups. In topic III, O / W were evaluated the effect of the degree of polymerization and length of the carboxylic acid carbon chain on the emulsifying capacity of the polyglycerol ester synthesized, for which optical microscopy techniques, surface tension measurements and stability time of the emulsions were used
Inefficient complement system clearance of Trypanosoma cruzi metacyclic trypomastigotes enables resistant strains to invade eukaryotic cells.
No full textThe complement system is the main arm of the vertebrate innate immune system against pathogen infection. For the protozoan Trypanosoma cruzi, the causative agent of Chagas disease, subverting the complement system and invading the host cells is crucial to succeed in infection. However, little attention has focused on whether the complement system can effectively control T. cruzi infection. To address this question, we decided to analyse: 1) which complement pathways are activated by T. cruzi using strains isolated from different hosts, 2) the capacity of these strains to resist the complement-mediated killing at nearly physiological conditions, and 3) whether the complement system could limit or control T. cruzi invasion of eukaryotic cells. The complement activating molecules C1q, C3, mannan-binding lectin and ficolins bound to all strains analysed; however, C3b and C4b deposition assays revealed that T. cruzi activates mainly the lectin and alternative complement pathways in non-immune human serum. Strikingly, we detected that metacyclic trypomastigotes of some T. cruzi strains were highly susceptible to complement-mediated killing in non-immune serum, while other strains were resistant. Furthermore, the rate of parasite invasion in eukaryotic cells was decreased by non-immune serum. Altogether, these results establish that the complement system recognizes T. cruzi metacyclic trypomastigotes, resulting in killing of susceptible strains. The complement system, therefore, acts as a physiological barrier which resistant strains have to evade for successful host infection
Caracterização de inibidores de complemento liberados pelas formas metacíclicas de Tripanosoma cruzi e sua função na evasão da imunidade inata
No full textFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, BrasilO Tripanosoma cruzi, agente etiológico da doença de Chagas, constitui um grave problema de saúde pública que afeta 18 milhões de pessoas na América latina. Para produzir a infecção formas tripomastigotas metacíclica de T. cruzi , liberadas durante a picada do inseto vetor, precisam evadir o sistema imune inato do hospedeiro vertebrado para infectar as células. O sistema complemento, devido à sua capacidade para rapidamente reconhecer e eliminar microrganismos constitui a principal linha de defesa do sistema imune inato. O sistema do complemento é composto por várias proteínas, ativadas em cascata por serino proteases, que culmina com a formação do complexo de ataque a membrana e lise do patógeno. Todavia, muitos organismos patogênicos desenvolveram formas de escapar do ataque do sistema do complemento por meio de diversos mecanismos. Visando à melhor caracterização dos fatores de virulência do T. cruzi, o grupo foi verificar se os sobrenadantes de formas metacíclicas apresentam atividade inibitória de complemento. Devido às vias do complemento serem ativadas por serino proteases, foi realizada uma busca no banco genômico de T. cruzi atrás de motivos de SERPINAS (inibidores de serino protease) que o parasito poderia estar liberando no primeiro contato parasito-hospedeiro. Foram realizados experimentos de lise mediada pelo complemento com sobrenadantes das formas metacíclicas de T. cruzi. Observou-se, ainda, que os sobrenadantes das formas metacíclicas do T. cruzi são capazes de inibir a lise mediada pelo complemento de formas epimastigotasThe Try panosoma cruzi, etiologic agent of Chagas disease, is a serious public health
concernthat affects 18 million people in Latin America. To produce the infection, metacyclic trypomastigotes de T cruzi released during the bite of the insect vector must evade the innate immune system of the vertebrate host to infect cells. The complement system, due to its ability to rapidly recognize and eliminate microorganisms is the major line of innate immune system defense. The complement system is composed of various proteins, activated by serine proteases cascade that culminates in the formation of the membrane attack complex and lysis of the pathogen. However, many pathogens have developed ways to evade the attack of the complement system through several mechanisms. Aiming to better characterize the virulence factors of
T. cruzi, the team was to verify whether the supernatants of metacyclic forms exhibit inhibitory activity of complement. Due to the complement pathways are activated by serine proteases, we seek in genomic library of T. cruzi motifs
related t
o
serpin (serine protease
inhibitors)
, a protein
that the parasite could be releasing
at
the first parasite
-
host
contact
.
Experiments were carried out to complement
-
mediated lysis with supernatants of metacyclic
forms of
T. cruzi
.
F
urthermore
, i
t was ob
served,
that the supernatants of metacyclic forms of
T. cruzi
are capable of inhibiting the complement mediated lysis of epimastigote
Single-chain polymeric systems: design, synthesis, and applications
No full textSubmission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2023-05-01The student, Edzna Garcia Ramirez, accepted the attached license on 2021-04-19 at 13:43.The student, Edzna Garcia Ramirez, submitted this Dissertation for approval on 2021-04-19 at 14:01.This Dissertation was approved for publication on 2021-04-20 at 16:17.DSpace SAF Submission Ingestion Package generated from Vireo submission #16413 on 2021-09-16 at 17:04:00Single-chain polymeric nanoparticles (SCNPs) have been explored for applications in biomedicine such as drug delivery, catalysis, and imaging. These SCNPs are generated from the intramolecular folding or collapse of the single-chain polymer where the collapse is achieved by self-assembly or covalent crosslinking. In this thesis, the intramolecular self-assembly of single-chain polymeric systems is explored in catalysis and fluorescence.
In Chapter 2, we developed an amphiphilic ruthenium-containing single-chain polymer that promotes allyl carbamate cleavage reactions in aqueous and biologically relevant conditions. This polymeric catalyst works in synergy with the enzyme β-galactosidase to perform a tandem reaction on a single substrate. Additionally, the polymer catalyst was characterized by various methods to study its self-assembly.
In Chapter 3, we investigated a modular approach to SCNPs for catalysis that consists of an amphiphilic single-chain polymer that folds under dilute aqueous conditions resulting in unimolecular micelle-like structures. This modular approach allows binding of various catalysts and substrates leading to reaction rate enhancement.
In Chapter 4, we developed fluorophore-containing single-chain polymers that may be useful in bioimaging. The polymers solubilized and stabilized various types of organic fluorophores leading to brighter and more stable fluorophores.Made available in DSpace on 2021-09-17T02:34:37Z (GMT). No. of bitstreams: 2
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Previous issue date: 2021-04-20Embargo set by: Seth Robbins for item 118541
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Play your Mood: un enllaç entre les emocions i el contingut emocional de la música
No full textTreball de fi de grau en Sistemes AudiovisualsTutor: Rafael Ramirez MeléndezL’objectiu principal d’aquest treball és el de generar un prototip funcional que permeti, a temps real, visualitzar l’estat anímic del subjecte. En aquest projecte es fan servir tècniques de Brain Computer Interface (BCI) tant per a la captació de senyals fisiològiques EEG /Electrocardiograma (ECG) com per a la posterior extracció de l’estat emocional del subjecte. A partir de l’aproximació d’aquest estat emocional, es selecciona i reprodueix una música classificada d’acord amb l’estat d’ànim. El reproductor permet visualitzar tant dades provinents de l’EEG, com de la música que està sonant. La qualitat de visualització és prioritària per després poder utilitzar-la en aplicacions de neuro-feedback. La viabilitat del treball esta fonamentada en estudis de Brain–Computer Interface (BCI), en els que es presenten algoritmes d’extracció de l’estat emocional. En aquest treball s’han escollits algoritmes que exploren la potència de les diferents freqüències de l’EEG, i en el nivell de simetria existent entre els dos hemisferis
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