1,721,795 research outputs found
A systems approach to tissue engineering processes and products – (STEPS)
No full textTissue engineering (TE) is a rapidly emerging collection of technologies aimed at the regeneration of tissues and organs for the treatment of disease and injury. Whilst some success has already been achieved, demonstrating the potential for TE to make a significant impact on healthcare, there has been a marked lack of connectivity between the different components such that TE will not deliver this promise under current conditions. STEPS addresses this by introducing a systems approach to TE and associated technologies. It is our clear objective to provide a totally new infrastructure, based upon the hypothesis that the only way to successfully implement TE is to systematically link together all aspects of this multi-disciplinary process by applying the logistics of systems engineering. Specifically, the technological components will include cell sourcing and manipulation, novel biomaterial development, bioreactor design and the integration of TE constructs into the living host. The programme incorporates a determination of the socio-economic issues related to ethics and health economics. This will include an assessment of the public acceptability of these emerging technologies and the ability of private and public health insurance to pay for it without detracting from more traditional medical procedures. The Consortium has therefore designed an objective-driven approach, set to deliver radical innovations in the long term as well as new processes, methodologies and products in the short and medium term. The potential world market for TE products is estimated at €100 billion but a poorly integrated infrastructure will be incapable of delivering to this market. We believe that this approach will transform the TE industrial infrastructure.
The Consortium comprises 23 partners from 13 European countries. It includes 6 industrial organisations, 4 of whom are SMEs and 17 academic centres. In order to tackle the development of such a highly innovative systems approach to TE, the contribution of a truly multi-disciplinary Consortium, of a critical mass in man power, and of substantial financial commitment, is required. These multidisciplinary skills are indeed found only within a European cooperation and all the partners are internationally identified centres of excellence in their respective areas of expertise
Incapsulamento delle regioni soggette ad usura delle protesi articolari
No full textIl presente trovato si riferisce all'incapsulamento mediante pareti elastiche o comunque flessibili di opportune dimensioni e forme (variabili a seconda dei casi) delle regioni soggette ad usura delle protesi articolari per isolarle dall'ambiente biologico circostante
Reply to comments on Grassi et al.: Clinical outcome and complications of a collagen meniscus implant: A systematic review
No full textClinical outcomes and complications of a collagen meniscus implant: a systematic review
Some remarks on the functional anatomy of the posterior compartment of the human knee (Oblique Popliteal Ligament). li. Alcune osservazioni di anatomia funzionale del compartimento posteriore del ginocchio umano (Legamento Popliteo Obliquo)
No full textBone marrow edema and results after cartilage repair
Full text linkBone marrow edema (BME) has been described in several areas of both knee pathology and treatment, with the first reports dating back more than two decades ago. However, even
though a very long time has passed since the first description by Wilson et al. in 1988 (1), BME remains a controversial entity not only in terms of clinical impact, but also for its still
unknown significance in etiopathological processes
Return to sport after ACL reconstruction: how, when and why? A narrative review of current evidence
No full textAllowing a patient to return to sport and unrestricted physical activity after ACL injury and reconstruction is one of the most challenging and difficult decisions an orthopaedic surgeon has to make. Indeed, many factors have to be taken into account before it can be considered safe for a patients to load a reconstructed knee. The current literature contains plenty of studies aimed at evaluating return to sport, and the factors that may affect or predict this outcome, e.g. intrinsic factors like genetics, biology, type of lesion, anatomical features, motivation and psychology, and extrinsic factors such as graft type, surgical technique, rehabilitation protocols, and biological support. It is possible that awareness of these issues could help the clinician to optimise outcomes, and possibly avoid failures too, although as yet no universal criteria for resuming sport have been produced
Platelet-rich plasma: evidence for the treatment of patellar and Achilles tendinopathy-a systematic review
No full textPlatelet-rich plasma (PRP) has been introduced in the clinical practice to treat a growing number of different musculoskeletal pathologies. It is currently applied in the treatment of Achilles and patellar tendinopathies, which are common sport-related injuries very challenging to manage. Aim of the present paper was to review systematically the available clinical evidence concerning the application of PRP in the treatment of patellar and Achilles tendinopathy. A systematic review of the literature was performed according to the following inclusion criteria for relevant articles: (1) clinical reports of any level of evidence, (2) written in the English language, (3) with no time limitation and (4) on the use of PRP to treat conservatively Achilles and patellar tendinopathy. Twenty-two studies were included and analyzed. Two studies on patellar tendinopathy were randomized controlled trials (RCTs), whereas just one RCT was published on Achilles tendon. All the papers concerning patellar tendon reported positive outcome for PRP, which proved to be superior to other traditional approaches such as shock-wave therapy and dry needling. In the case of Achilles tendon, despite the encouraging findings reported by case series, the only RCT available showed no significant clinical difference between PRP and saline solution. The main finding of this study was the paucity of high-level literature regarding the application of PRP in the management of patellar and Achilles tendinopathy. However, the clinical data currently available, although not univocal, suggest considering PRP as a therapeutic option for recalcitrant patellar and Achilles tendinopathies
European Definitions, Current Use, and EMA Stance of Platelet-Rich Plasma in Sports Medicine.
No full textPlatelet-rich plasma has been the focus of much attention over the last few years as an appealing biological approach to favor the healing of tissues otherwise doomed by a low healing potential. In Europe, the regulatory framework concerning the blood system is currently disciplined by Directive 2002/98/EC of the European Parliament and Council of January 27, 2003, which sets out quality and safety rules for collecting, controlling, processing, preserving, and distributing human blood and its components, acknowledged in the various States of the Union with internal regulations. This lack of homogeneity in the European legal landscape will probably lead the Community legislature to intervene in the near future, to even out the "rules of engagement" of this peculiar class of biomaterials
Second generation issues in cartilage repair
No full textIn recent years, regenerative techniques, such as autologous chondrocyte implantation (ACI), have emerged as a potential therapeutic option for the treatment of chondral lesions. However, the good results reported have to be weighed against the number of problems that can be observed with traditional ACI methods. To address these problems, the so-called second generation ACI techniques have been developed. Autologous chondrocyte transplantation on a 3-dimensional matrix was introduced in clinical practice from 1998 to 1999 and results at short to medium-term follow-up are well documented for different types of scaffolds. These techniques may be used for the treatment of large chondral lesions in the young, active population and highly competitive athletes, but long-term and randomized controlled studies will be needed to confirm reliability of these procedure
METODO PER LA PRODUZIONE DI IMPIANTI ORTOPEDICI ANTI-USURA
No full textLa presente invenzione si riferisce ad un metodo per produrre componenti di un impianto ortopedico resistenti all’usura ed alla corrosione, detto metodo comprendente una fase di deposizione in vuoto di un materiale ceramico anti-usura sulla superficie di dette componenti. In particolare, le componenti a cui la presente invenzione fa riferimento sono le componenti di una protesi articolare, per esempio la protesi del ginocchio, dell’anca, del polso, del gomito, della spalla, della caviglia, delle dita o della colonna vertebrale
- …
