347 research outputs found
Arthur Symons Translator of Gabriele D'Annunzio's Plays
No full textThe article analyzes Symons rythmic translations of D'Annunzio's plays, their performances and literary reception and adds a list of all of D'Annunzio's works in English as well as holograph letters of the author and his English translator
Regulation of Anoikis by Cdc42 and Rac1
No full textRas family small GTPases play a critical role in malignant transformation , and Rho subfamily members contribute significantly to this process. Anchorage-independent growth and the ability to avoid detachment-induced apoptosis ( anoikis) are hallmarks of transformed epithelial cells. In this study, we have demonstrated that constitutive activation of Cdc42 inhibits anoikis in Madin-Darby canine kidney (MDCK) epithelial cells. We showed that activated Cdc 42 stimulates the ERK, JNK, and p38 MAPK pathways in suspension condition; however, inhibition of these signaling does not affect Cdc42-stimulated cell survival. However, we demonstrated that inhibition of phosphatidylinositol 3- kinase (P13K) pathway abolishes the protective effect of Cdc 42 on anoikis. Taking advantage of a double regulatory expression system, we also showed that Cdc42-stimulated cell survival in suspension condition is, at least in part, mediated by Rac1. We also provide evidence for a positive feedback loop involving Rac1 and P 13K. In addition, we show that the survival functions of both constitutively active Cdc42 and Rac1 GTPases are abrogated by Latrunculin B, an actin filament-depolymerizing agent, implying an important role for the actin cytoskeleton in mediating survival signaling activated by Cdc42 and Rac1. Together, our results indicate a role for Cdc42 in anchorage- independent survival of epithelial cells. We also propose that this survival function depends on a positive feedback loop involving Rac1 and P 13K. (C) 2004 Elsevier Inc. All rights reserved
“Serious in the Reality of his Devotion to Art”: The Genealogy of Symons’s Assessment in “A Study of Oscar Wilde”
No full textIl saggio si propone di testimoniare l’ampiezza degli interessi di Arthur Symons, nonché il suo fondamentale ruolo di critico e mediatore culturale a cavallo tra Otto e Novecento, ricomponendo il mosaico delle valutazioni da lui espresse su Oscar Wilde (uomo e artista) nell’arco di mezzo secolo. A un’analisi delle frequentazioni e di alcuni scritti miscellanei di Symons (lettere, recensioni, articoli) segue una focalizzazione su “A Study of Oscar Wilde” (1930), volume finora trascurato dalla critica nel quale l’autore rielaborò estratti dalle proprie opere precedenti integrandoli in una struttura più coesa e con un chiaro intento progettuale. Benché talora vi affiorino contrasti e sbavature tipici della produzione successiva al 1908 (l’anno drammatico del crollo nervoso di Symons), questo libro della maturità traccia un interessante percorso retrospettivo che si conclude fornendo un quadro esegetico sostanzialmente convincente. In più di una circostanza, inoltre, Symons evidenzia coraggiosamente la serietà della “devozione artistica” di Wilde in un’epoca che, come quella modernista, appariva a dir poco scettica nei confronti dell’esteta irlandese. L’elaborato si prefigge dunque di mostrare come “A Study of Oscar Wilde” debba considerarsi sia un’opera significativa all’interno del macrotesto di Symons, sia un raro esempio di apprezzamento di Wilde nella prima metà del Novecento. È lecito ipotizzare che questo volume del 1930 abbia siglato un cambiamento di direzione negli studi wildiani, anticipando, tra gli altri, il valido “Aspects of Wilde” (1936) di Vincent O’Sullivan.This chapter testifies to the breadth of Arthur Symons’s interests, to his crucial role as subtle critic and cultural mediator between the 19th and 20th centuries, by tracing the genealogy of his assessment concerning the personality and literary production of Oscar Wilde across five decades. An analysis of Symons’s connections, correspondence, reviews and articles is followed by a more specific focus on “A Study of Oscar Wilde” (1930), a so-far neglected volume in which the author partly drew on his previously published works but also endeavoured to provide them with a consistent framework. If occasionally biased or disjointed (a condition characterizing most of Symons’s post-1908 writings), this book reconsiders earlier critical stances going back to the late 1880s and succeeds in offering a final, convincing perspective on Wilde. In various passages, Symons boldly underlines the earnestness of the latter’s artistic commitment in an age in which any Wildean reminiscence encountered general indifference, if not downright oblivion. In the upshot, “A Study of Oscar Wilde” emerges as both a valuable contribution within Symons’s canon and a groundbreaking example of Wilde’s serious reception during Modernism. It marked a change in direction in 1930s’ Wilde scholarship and anticipated, among others, Vincent O’Sullivan’s commendable “Aspects of Wilde” (1936)
The quiet eye and tasks demands: Do tougher shots need a quieter eye?
No full textThe Quiet Eye (QE; Vickers 1996) has been shown to underpin successful performance, differentiating both expertise (inter-individual) and proficiency (intra-individual), with experts and successful attempts characterised by longer QE durations. The QE is proposed to reflect the time needed to organise and fine tune the parameters of movement (e.g. force and direction). In order to examine this prediction and build upon previous research we experimentally manipulated the difficulty of a golf putting task; we hypothesised that if the QE is related to motor programming then a more difficult task should be associated with longer QE durations.
33 golfers (M age= 21.16, SD= 3.98) with an average handicap of 6.5 (SD= 6.02) performed putts in 4 conditions of increasing difficulty. We manipulated the length of the golf putt (short-4ft, long-8ft) and the contact point of the putter head (large-1.7cm, small-0.5cm,) giving increasingly difficult putting conditions of short-large [1], short-small [2], long-large [3] and long-small [4]. We measured performance (radial error from hole in cm) and QE (in ms) for 10 putts in each condition.
A repeated measures ANOVA was performed on the performance and QE data. The performance data suggest that we were successful in increasing the difficulty of the task (F (3,93) = 26.46. p = .000), with the best performance in condition [1] (8.57cm), followed by [2] (9.10cm) followed by [3] (16.11cm) and finally the worst performance was in condition [4] (23.40cm). The QE data suggest that, in keeping with our hypothesis, the QE was lengthened as task difficulty increased (F (3,87) = 11.91, p = .043). The QE was shortest in condition [1] (1787.85ms) and increased to condition [2] (1939.78ms) and condition [3] (2076.51ms), with the longest QE in condition [4] (2164.08ms). More detailed analysis of the QE reveal that it was the proportion of the QE that occurred before movement initiation (pre-QE) which increased with shot difficulty, rather than the proportion that occurred during the swing (Online-QE; see Vine et al., 2013).
Results support the notion that more complex tasks are associated with a longer QE duration, specifically participants appear to spend longer fixating the target prior to movement. This likely reflects the time needed to process visual information gathered in a pre-performance routine, to inhibit external distraction, and to pre-programme the increasingly difficult parameters of the movement.
Vickers, J.N. (1996). Visual control when aiming at a far target. Journal of Experimental Psychology: Human Perception and Performance, 22, 342-354.
Vine, S.J. et al. (2013). Quiet eye and choking: Online control breaks down at the point of performance failure. Medicine and Science in Sports and Exercise, 45, 1988-1994
Author rights, open access, and you!
No full textLibrarians present a session on author rights, copyright and permissions, and best practices for curating faculty members’ online presence, and talk about the benefits of making one’s work openly available on DigitalCommons@CSB/SJU
Adhesion signaling: PAK meets Rac on solid ground
No full textAbstractInteraction of cells with the extracellular matrix influences various aspects of cellular behavior. A recent study shows that cell–substrate adhesion is necessary for effective coupling of the small GTPase Rac to its effector PAK
Behaviour of buried pipelines subjected to external loading.
No full textThe research presented in this Thesis was carried out at the University of Sheffield under
the supervision of Dr I. C. Pyrah and Dr W. F. Anderson, and Mr G. Leach at British Gas
Engineering Research Station (ERS). The research was financially supported by a British
Gas Research Scholarship and by the Overseas Research Students Awards Scheme.
The Author would like to express his sincere gratitude to his supervisors for their invaluable
help, guidance and encouragement during the development of the research.
The Author is also grateful to Dr S. R. Mi for his interest and assistance throughout the
research. Special thanks also go to Dr S. J. Wheeler for his supervision during the first year
of the research and sound advice in the initial stage of the work.
The Author would like to express his gratitude to all members of the geotechnics group at
the University of Sheffield for the useful discussions and comments. Special thanks and
appreciation are extended to the staff at the ERS, particularly Mr E. Middleton for
providing the data of the field tests and constructive comments.
The laboratory tests were performed at ERS Soils Laboratory for which the Author is
thankful to the laboratory staff. The Author must also thank British Gas for providing the
computer hardware and software for performing the numerical analyses, and the printing
facilities to produce the Thesis. Thanks also go to Mr D. Reay and Mr B. Bellwood at the
Gas Research Centre of British Gas for ensuring continuous financial support throughout
the award period.
Finally, the Author wishes to thank his family and friends for their endless support and
encouragement throughout the period of study in the UK. Without them, this Thesis may
never have been completed
A curriculum on care for people with disabilities: Effects on medical student self-reported attitudes and comfort level
No full textBackground Early, frequent encounters with people with disabilities may improve medical students' knowledge, attitudes and skills regarding their care. We developed and implemented a longitudinal four-year curriculum addressing caring for people with disabilities. Objectives-hypothesis To test differences in mean scores between intervention and control groups on individual post-survey items regarding attitudes toward people with disabilities, and to conduct exploratory procedures to examine individual factors that may account for group differences. Methods Students at two U.S. medical schools, one with the new curriculum, and one with no specific disabilities curriculum, were surveyed in Year 1 of medical school, prior to curriculum introduction, and again at the end of Year 3, using a validated 30-item instrument measuring medical students' self-reported attitudes and comfort toward people with disabilities. We compared mean item ratings between the two groups using χ2 and ANOVA. Principal components analysis was then used to construct linear composite variables that were then regressed on potential predictors of attitudes and comfort level. Results The intervention led to significant or near-significant improvement in several factors. However, male students in the intervention group, particularly those who encountered people with disabilities in a clinical context, had a tendency to more frequently agree with negative statements (β =.628, p =.005). Conclusions Exposure of medical students to a longitudinal curriculum for caring for people with disabilities led to significant improvement in several factors related to comfort and attitudes. The gender-related reinforcement of some negative attitudes merits further investigation and caution when implementing the curriculum in the future. © 2014 Elsevier Inc. All rights reserved.Breslin ML, 2007, JAMA-J AM MED ASSOC, V297, P1121; Brown RS, 2010, ACAD MED, V85, P1766, DOI 10.1097-ACM.0b013e3181f849dc; Bryan RE, 2005, ANN ACAD MED SINGAP, V34, P486; Carmona RH, 2010, DISABIL HEALTH J, V3, P229, DOI 10.1016-j.dhjo.2010.07.004; Carrothers LA, 2002, PROVIDING PRIMARY HE; Chadd EH, 2011, AM J PHYS MED REHAB, V90, P47, DOI 10.1097-PHM.0b013e3182017269; Chaplin R, 2009, J INTELL DISABIL RES, V53, P189, DOI 10.1111-j.1365-2788.2008.01143.x; Chaplin R, 2004, J INTELL DISABIL RES, V48, P1, DOI 10.1111-j.1365-2788.2004.00580.x; Costello H, 2007, J APPL RES INTELLECT, V20, P228, DOI 10.1111-j.1468-3148.2006.00320.x; Crotty M, 2000, MED EDUC, V34, P659, DOI 10.1046-j.1365-2923.2000.00621.x; Goreczny AJ, 2011, RES DEV DISABIL, V32, P1596, DOI 10.1016-j.ridd.2011.02.005; Iezzoni LI, 2012, DISABIL HEALTH J, V5, P136, DOI 10.1016-j.dhjo.2012.03.003; Jackson KB., 2007, THESIS; Karl R, 2013, INTELLECT DEV DISAB, V51, P237, DOI 10.1352-1934-9556-51.4.237; Kirschner KL, 2009, JAMA-J AM MED ASSOC, V302, P1334, DOI 10.1001-jama.2009.1398; Krahn GL, 2011, DISABIL HEALTH J, V4, P141, DOI 10.1016-j.dhjo.2011.05.001; Lam WY, 2010, J NEUROENG REHABIL, V7, DOI 10.1186-1743-0003-7-55; Minihan PM, 2011, ACAD MED, V86, P1171, DOI 10.1097-ACM.0b013e3182264a25; Morrison EH, 2008, FAM MED, V40, P645; PARIS MJ, 1993, ARCH PHYS MED REHAB, V74, P818, DOI 10.1016-0003-9993(93)90007-W; Robey KL, 2006, J DEV PHYS DISABIL, V18, P441, DOI 10.1007-s10882-006-9027-3; Rose N, 2012, J INTELL DISABIL RES, V56, P854, DOI 10.1111-j.1365-2788.2011.01476.x; Rudman LA, 2001, J PERS SOC PSYCHOL, V81, P856, DOI 10.1037--0022-3514.81.5.856; Shah Payal, 2005, J Pediatr Adolesc Gynecol, V18, P101, DOI 10.1016-j.jpag.2005.01.004; Smith DL, 2009, DISABIL HEALTH J, V2, P206, DOI 10.1016-j.dhjo.2009.06.002; Symons A, 2012, INTELLECT DEV DISAB, V50, P251, DOI 10.1352-1934-9556-50.3.251; Symons AB, 2009, BMC MED EDUC, V9, DOI 10.1186-1472-6920-9-78; ten Klooster PM, 2009, J ADV NURS, V65, P2562, DOI 10.1111-j.1365-2648.2009.05146.x; Tervo RC, 2004, CLIN REHABIL, V18, P908, DOI 10.1191-0269215504cr820oa; Tervo RC, 2002, ARCH PHYS MED REHAB, V83, P1537, DOI 10.1053-apmr.2002.34620; U. S. Department of Commerce Economics and Statistics Administration U. S. Census Bureau, 2011, AMERICANS WITH DISAB; U. S. Department of Health and Human Services Office of Disease Prevention and Health Promotion, 2010, HLTH PEOPL 2020; United States Department of Health and Human Services, 2000, HLTH PEOPL 2010; Weinrich M, 2011, ACAD MED, V86, P1069, DOI 10.1097-ACM.0b013e3182263429; Wilkinson J, 2012, INTELLECT DEV DISAB, V50, P243, DOI 10.1352-1934-9556-50.3.243; World Health Organization, 2010, DISABILITY AND REHAB; WRIGHT BA, 1980, REHABIL LIT, V41, P2740
MoNUment: Natuursteencollecties deel 12
No full textVoor de twaalfde editie van de serie over natuursteencollecties werd Wido Quist getipt om het moNUment voor vrede, veiligheid en samenleving, in 2010 gemaakt door kunstenaar Jerome Symons in Bergen op Zoom, eens nader te bekijken. Hierbij een verslag.Heritage & Technolog
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