1,131 research outputs found
T-cell activation in health and disease
No full textA small conference{black star} {black star} The conference was held at Trinity College Oxford, UK, on 13-17 September 1987 and was organized by Mike Crumpton, Jonathan Lamb, Liz Simpson, Jim Woody and Marc Feldmann. on T-cell activation reviewed the recent rapid progress in this field, following the effective adoption of a combination of clonal, cellular and molecular techniques. © 1988
Pipe flow simulation data illustrating the influence of filter kernels on the scale-energetics of near-wall turbulence
No full textOriginally developed for large-eddy simulation (LES) modelling and error estimation, the concept of inter-scale energy fluxes, π λ, is now widely used as a diagnostic tool to study how energy is transferred across different length scales, λ, in high-resolution turbulence data---independent of LES modelling. In Feldmann et al. (2025), we examine how the choice of filter kernel affects the computed energy fluxes and their interpretation when π is used in post-processing to explore scale interactions in near-wall turbulence. To this end, spatial filtering is applied to a turbulent pipe flow simulation using three commonly used kernels: sharp spectral, Gaussian, and box. The dataset enables a detailed comparison of how these different filters influence both the local structure and statistical characteristics of π at constant filter width. These data support the findings presented in Feldmann et al. (2025) and are provided to facilitate further studies on filtering effects and energy transfer in wall-bounded turbulent flows. This dataset includes velocity fields and energy flux fields based on three different filter kernels, as well as one- and two-point statistics for all field data sets
Tolerance in T-cell clones.
No full textThe interaction of antigen with immunologically competent cells may lead either to the induction of an immune response or to a state of antigen specific unresponsiveness complete orpartial, which is often called immunological 'tolerance'. This is believed to be a major mechanism of discrimination between self and non-self(1-3). In this review Marc Feldmann and his colleagues discuss new insights into T-cell tolerance in vivo and in vitro, and discuss their significance for our understanding of mechanisms of immune activation and regulation
Remyranina Schweitzer & Feldmann 2010, n. gen.
No full textGenus Remyranina n. gen. TYPE SPECIES. — Raninella ornata Remy, 1960. ETYMOLOGY. — Th e generic name combines the name of the author of the type species and prominent French paleontologist, Jean-Marcel Remy, and Ranina, the type genus of the family. OCCURRENCE. — Th e sole specimen was collected from probable Eocene rocks of Ivory Coast, Africa. DIAGNOSIS. — Small raninid with expanded, moderately broad fronto-orbital margin; ovoid, slightly longer than wide, with carapace ornamentation granular in anterior half and strongly terraced in posterior half. DESCRIPTION. — As for emended description of species. DISCUSSION Although the specimen referred to the new genus clearly allies it with the Ranininae, the combination of characters is unique and readily justifies creation of the new taxon. Th e genus to which it is most closely allied is Lophoranina Fabiani, 1910. Th ese two genera are the only ones in the Raninidae that are characterized by possession of a trifid rostrum and development of terraced ornamentation. However, Lophoranina tends to be widest near the front or at the level of the last anterolateral spine, whereas Remyranina n. gen. is broadest at the midlength, well posterior to the anterolateral spines. Furthermore, the anterolateral spines and the postorbital spines on Lophoranina are generally small, whereas those on Remyranina n. gen. are large. Finally, the terraced lines of Lophoranina extend nearly to the front of the carapace, well in advance of the branchiocardiac grooves, whereas those on Remyranina n. gen. are confined to the posterior half of the carapace. Th ere seems to be no other genus of raninids with which Remyranina n. gen. could be confused.Published as part of Schweitzer, Carrie E. & Feldmann, Rodney M., 2010, New fossil decapod crustaceans from the Remy Collection, Muséum national d'Histoire naturelle, Paris, pp. 399-415 in Geodiversitas 32 (3) on page 401, DOI: 10.5252/g2010n3a3, http://zenodo.org/record/468845
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