168 research outputs found
Statistical Considerations for Trials in Adjuvant Treatment of Colorectal Cancer
No full textThe design of the best possible clinical trials of adjuvant interventions in colorectal cancer will entail the use of both time-tested and novel methods that allow efficient, reliable and patient-relevant therapeutic development. The ultimate goal of this endeavor is to safely and expeditiously bring to clinical practice novel interventions that impact patient lives. In this paper, we discuss statistical aspects and provide suggestions to optimize trial design, data collection, study implementation, and the use of predictive biomarkers and endpoints in phase 3 trials of systemic adjuvant therapy. We also discuss the issues of collaboration and patient centricity, expecting that several novel agents with activity in the (neo)adjuvant therapy of colon and rectal cancers will become available in the near future
La conciliation judiciaire et sa coexistence avec les principaux modes amiables du Code judiciaire
No full textHistorique de la conciliation judiciaire et du développement des MARC / MARL ; Spécificités de la conciliation par le juge; Posture du tiers conciliateur (impartialité, neutralité ? contrôle de légalité ?) et décorum; Comparaison entre la conciliation judiciaire, la médiation et le droit collaboratif; Perspectives en vue d'une réforme des MARC
Multiple myeloma: patient outcomes in real-world practice
No full textWith increasing number of therapies available for the treatment of multiple myeloma, it is timely to examine the course of patients’ journeys. We investigated patient characteristics, treatment durations and outcomes, and
symptom burden across the treatment pathway in Belgium, France, Germany, Italy, Spain, Switzerland and the UK. In total, 435 physicians retrospectively reviewed 4997 patient charts. Profiles of patients diagnosed with
multiple myeloma during the last 12 months were similar across countries; bone pain was the most common presentation. Median duration of firstline therapy was 6 months, followed by a median treatment-free interval of
10 months; both these decreased with increasing lines of therapy, as did time to progression. Depth of response, as assessed by the treating physician, also decreased with each additional line of therapy: 74% of patients
achieved at least a very good partial response at first line, compared with only 11% at fifth line. Deeper responses were associated with longer time
to progression, although these were physician-judged. Toxicities and comorbidities increased with later treatment lines, and were more likely to have led to discontinuation of treatment. These real-world data provide an insight into patient outcomes and treatment decisions being made in clinical practice
Multiple myeloma: practice patterns across Europe
No full textReal-world data describing management of patients with multiple myeloma are limited. A European (Belgium, France, Germany, Italy, Spain, Switzerland, UK) observational chart review was conducted to address this. Physicians completed questionnaires for every patient seen during a 2-4-week observation period, regardless of treatment status. A total of 435 physicians completed 7635 cross-sectional chart reviews. Overall, 47% of patients were undergoing anti-tumour drug treatment, 42% had previously received ≥1 line of treatment and 12% had never received anti-tumour drug treatment. Of the patients treated by oncologists, onco-haematologists or internists, 95% received, or were expected to receive, at least one line of anti-tumour drug treatment, 61% received ≥2 lines of therapy and 38% received ≥3 lines. Except in the UK, the most commonly used induction therapies contained bortezomib (48%); lenalidomide was the most commonly used first-line maintenance therapy (45%) and second- and third-line agent overall (60% and 52% of patients at those lines, respectively). Bortezomib retreatment was used in 47% of patients who received it first line. Treatment patterns became more diverse with subsequent treatment lines. This study provides insight into real-world treatment patterns in Europe. While treatment practices are broadly similar across countries, some notable differences in the agents used exist
Thomas Morard, Horizontalité et verticalité. Le bandeau humain et le bandeau divin chez le Peintre de Darius
No full textCet ouvrage est issu d’une thèse soutenue en 2008 à l’Université Lumière – Lyon 2, sous la direction de Jean-Marc Moret. L’étude porte sur un groupe de vases particuliers, à savoir des pièces apuliennes dont le décor est divisé en deux frises superposées : la frise supérieure est réservée aux divinités et la frise inférieure aux humains. Bien que ces vases aient très tôt suscité l’attention, aucune étude systématique n’avait encore été consacrée à ce type de représentation, ce que propose de ..
Enseigner à distance en temps de confinement : enquête auprès des enseignants de langues en Belgique francophone
No full textpeer reviewedIn the context of the lockdown period and the consequent school closures between March and May 2020 in the Wallonia-Brussels Federation, our study aims at mapping the respondents' pedagogical uses of digital technology and their feelings about their experience of distance teaching, via a short online survey completed by 331 primary and secondary school foreign language teachers. Our analysis, both quantitative and qualitative, shows a massive use of platforms, e-mail and educational content creation tools in language teaching. It also highlights some significant differences in usage between teachers with previous experience of digital practices and those who discovered these practices during the period. In addition, the results show contrasting feelings of the respondents regarding this teaching experience, which seem to depend in particular on the means at their disposal. Finally, the results question the training of teachers and pupils in digital literacies as well as the access to digital tools and equipment for all, before suggesting a reflection on the lessons to be learnt from this experience for the future of teaching.Dans le contexte de la période de confinement et, partant, de la fermeture des établissements scolaires entre mars et mai 2020 en Fédération Wallonie-Bruxelles, la présente étude vise, sur base d'une enquête en ligne à laquelle 331 enseignants de l'enseignement fondamental et secondaire ont participé, à cartographier à la fois les usages pédagogiques du numérique des répondants pendant cette période et leur ressenti quant à leur expérience d'enseignement à distance.
Notre analyse, quantitative et qualitative, montre une forte utilisation des plateformes, du courriel et des outils de création de contenu éducatif dans le cadre de l'enseignement des langues à distance. Elle souligne également quelques différences significatives d'usage entre les enseignants ayant déjà une expérience des pratiques pédagogiques numériques et ceux ayant découvert ces pratiques pendant cette période. En outre, les résultats mettent en avant des retours d'expérience contrastés de la part des répondants quant à l'expérience vécue. Les résultats questionnent, enfin, la formation aux compétences numériques des enseignants et des élèves ainsi que l'accès aux outils numériques et à l'équipement pour tous, avant de proposer une réflexion sur les leçons à tirer de cette expérience pour le futur de l'enseignement
Enseigner à distance en temps de confinement : enquête auprès des enseignants de langues en Belgique francophone
No full textIn the context of the lockdown period and the consequent school closures between March and May 2020 in the Wallonia-Brussels Federation, our study aims at mapping the respondents' pedagogical uses of digital technology and their feelings about their experience of distance teaching, via a short online survey completed by 331 primary and secondary school foreign language teachers.Our analysis, both quantitative and qualitative, shows a massive use of platforms, e-mail and educational content creation tools in language teaching. It also highlights some significant differences in usage between teachers with previous experience of digital practices and those who discovered these practices during the period. In addition, the results show contrasting feelings of the respondents regarding this teaching experience, which seem to depend in particular on the means at their disposal. Finally, the results question the training of teachers and pupils in digital literacies as well as the access to digital tools and equipment for all, before suggesting a reflection on the lessons to be learnt from this experience for the future of teaching
Enseigner à distance en temps de confinement : enquête auprès des enseignants de langues en Belgique francophone
No full textpeer reviewedDans le contexte de la période de confinement et, partant, de la fermeture des établissements scolaires entre mars et mai 2020 en Fédération Wallonie-Bruxelles, la présente étude vise, sur base d'une enquête en ligne à laquelle 331 enseignants de l'enseignement fondamental et secondaire ont participé, à cartographier à la fois les usages pédagogiques du numérique des répondants pendant cette période et leur ressenti quant à leur expérience d'enseignement à distance.
Notre analyse, quantitative et qualitative, montre une forte utilisation des plateformes, du courriel et des outils de création de contenu éducatif dans le cadre de l'enseignement des langues à distance. Elle souligne également quelques différences significatives d'usage entre les enseignants ayant déjà une expérience des pratiques pédagogiques numériques et ceux ayant découvert ces pratiques pendant cette période. En outre, les résultats mettent en avant des retours d'expérience contrastés de la part des répondants quant à l'expérience vécue. Les résultats questionnent, enfin, la formation aux compétences numériques des enseignants et des élèves ainsi que l'accès aux outils numériques et à l'équipement pour tous, avant de proposer une réflexion sur les leçons à tirer de cette expérience pour le futur de l'enseignement.In the context of the lockdown period and the consequent school closures between March and May 2020 in the Wallonia-Brussels Federation, our study aims at mapping the respondents' pedagogical uses of digital technology and their feelings about their experience of distance teaching, via a short online survey completed by 331 primary and secondary school foreign language teachers.
Our analysis, both quantitative and qualitative, shows a massive use of platforms, e-mail and educational content creation tools in language teaching. It also highlights some significant differences in usage between teachers with previous experience of digital practices and those who discovered these practices during the period. In addition, the results show contrasting feelings of the respondents regarding this teaching experience, which seem to depend in particular on the means at their disposal. Finally, the results question the training of teachers and pupils in digital literacies as well as the access to digital tools and equipment for all, before suggesting a reflection on the lessons to be learnt from this experience for the future of teaching
ImmunoStart: preparing patients for immunosuppression
No full textObjectives. Patients with immune-mediated inflammatory disease (IMID) present an increased risk of infection. Here, we present the concept of a preventive consultation called ImmunoStart and the first results of its implementation in the care pathway of patients with IMID. Methods. Relevant information about vaccination history, tuberculosis exposure and other infectious risks were collected through blood sampling, complete anamnesis, chest X-ray and Mantoux test. During the ImmunoStart consultation, vaccination schedules, specific treatments and risk considerations were discussed. Results. Between October 2016 and February 2020, 437 patients were seen at an ImmunoStart consultation, mainly referred by rheumatologists (56%), dermatologists (25%) and gastroenterologists (18%). A total of 421 (96%) patients needed at least one vaccine (a mean of 3.3 vaccines per patient). Live attenuated vaccine was indicated for 45 patients (10%), requiring them to reduce or interrupt their immunosuppressive drug(s). Ninety-two patients (21%) were treated for latent tuberculosis infection. Conclusion. This preventive consultation provides a centralized and systematic setting for the direct management of patients with IMID in need of vaccination, treatment of latent disease and specific advice regarding their immunomodulating treatments.The authors thank Julie Massart, Khadra Massaoudi and Khadija Tarfi for their valuable help in coordinating and caring for ImmunoStart patients, as well as colleagues Christine Ellis, Charlotte De Volder and Thibaut Van Baelen for their help in the ImmunoStart consultation. They also thank Emile Freteur for her efficient work and support. C.M. created the ImmunoStart consultation in collaboration with V.M., C.B., L.M.B., X.L. and S.D.R. C.M. is the head of the ImmunoStart clinic. C.M. collected the data and drafted the initial manuscript. V.M., C.B., L.M.B., X.L., S.D.R. and J.V. reviewed and edited the manuscript and provided substantial comments. Funding: No specific funding was received from any bodies in the public, commercial or not-for-profit sectors to carry out the work described in this article. Disclosure statement: The authors have declared no conflicts of interest
Marc Augé, Cornélius Castoriadis, Maria Daraki, Philippe Descola, Claude Mossé, André Motte, Gilbert Romeyer-Dherby, Marie-Henriette Quet, La Grèce pour penser l’avenir
No full text- …
