87,918 research outputs found
Stereoselective Synthesis of Substituted 1,2-Ethylenediaziridines and Their Use as Ligands in Palladium-Catalyzed Asymmetric Allylic Alkylation
No full textThe double addition of organometallic reagents to fused oxazino-oxazines prepared from glyoxal and (S)-phenylglycinol afforded C2- or C1-symmetric 1,2-ethylenebis(-aminoalcohols), depending on the nature of the organometallic reagent. This route was modified by the use of (S)-valinol and phenylglyoxal as starting materials, and by reduction of the oxazino-oxazines by diborane. Cyclization of the -aminoalcohol moieties gave 1,2-ethylenediaziridines bearing one substituent/stereocenter on the ring carbon and one, two or no substituents/stereocenters in the ethylene tether. These bis(aziridines) were used as ligands in the Pd-catalyzed allylic alkylation of dimethyl malonate. It was established that the substituent(s) in the carbon tether and the configuration of the corresponding stereocenters have limited influence on the enantioselectivity
Angiotensin-converting enzyme content of human spermatozoa and its release during capacitation.
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Chicken immune cell assay to evaluate the immune-modulating effect of grape by-products
No full textAgro-industrial by-products offer sustainable and cost-effective alternatives to traditional feedstuffs. Grape
by-products (GP) come from winery and are known to be rich in phenolic compounds. We evaluated the immunomodulatory effect of GP on chicken immune cells by isolating peripheral blood mononuclear cells (PBMC)
from chicken blood and exposing them to various GP forms. Original GP (oGP) was digested in vitro using
the INFOGEST protocol to obtain digested GP (ivdGP). Phenolic compounds were extracted from oGP using
a water:ethanol solution, yielding extracted GP (extGP). We measured total phenolic content in oGP and extGP
with a colorimetric Folin assay. Chicken PBMC were treated for 24 h with oGP, ivdGP, and extGP, and immunophenotyping was applied using flow cytometry. The extGP treatment increased the proportion of dead cells but
significantly enhanced CD4+CD25+ and CD8+CD25+ T cells activation, suggesting that extGP induced T cell
activation without promoting proliferation. No significant changes were observed in CD4 and CD8 T cell activation with other treatments, nor did any treatment significantly affected B cells. To conclude, only extGP enhanced
CD4 and CD8 T cell activation among the tested GP forms, highlighting its potential immunomodulatory role in
chicken PBMC immune response. This suggests that specific GP forms can influence the immune system, providing insights for their use for poultry nutrition and health management
Quality in the extra-analytical phases of urinalysis.
No full textQuality in the extra-analytical phases of urinalysis
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
[Newspaper Clipping: Author Claims Evidence of Second JFK Assassin #1]
No full textNewspaper article titled "Author Claims Evidence of Second JFK Assassin." The article states that author Richard J. Whalen concluded "that there is circumstantial evidence to support the theory of a second assassin in the shooting of President John F. Kennedy.
Shedding light on nocturnal movements in parkinson’s disease: Evidence from wearable technologies
No full textIn Parkinson’s disease (PD), abnormal movements consisting of hypokinetic and hyperkinetic manifestations commonly lead to nocturnal distress and sleep impairment, which significantly impact quality of life. In PD patients, these nocturnal disturbances can reflect diseaserelated complications (e.g., nocturnal akinesia), primary sleep disorders (e.g., rapid eye movement behaviour disorder), or both, thus requiring different therapeutic approaches. Wearable technologies based on actigraphy and innovative sensors have been proposed as feasible solutions to identify and monitor the various types of abnormal nocturnal movements in PD. This narrative review addresses the topic of abnormal nocturnal movements in PD and discusses how wearable technologies could help identify and assess these disturbances. We first examine the pathophysiology of abnormal nocturnal movements and the main clinical and instrumental tools for the evaluation of these disturbances in PD. We then report and discuss findings from previous studies assessing nocturnal movements in PD using actigraphy and innovative wearable sensors. Finally, we discuss clinical and technical prospects supporting the use of wearable technologies for the evaluation of nocturnal movements
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