1,729,628 research outputs found
A study of heat transfer and fluid flow in the electroslag refining process
Full text linkThesis (Sc.D.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 1980.MICROFICHE COPY AVAILABLE IN ARCHIVES AND SCIENCE.Vita.Includes bibliographical references.by Manoj Kumar Choudhary.Sc.D
RECTIFIED DIFFERENTIAL CRYPTANALYSIS OF 16 ROUND PRESENT
No full textRECTIFIED DIFFERENTIAL CRYPTANALYSIS OF 16 ROUND PRESENT
Manoj Kumar , Pratibha Yadav and Meena Kumari
SAG, DRDO, Metcalfe House, Delhi-110054, India
ABSTRACT
In this paper, we have suggested rectifications in differential cryptanalysis of ultra-lightweight block cipher PRESENT reduced to 16 rounds. We have shown that proposed differential attack by Wang [3] on 16 round PRESENT can recover at the most 30 subkey bits, although the author has claimed to recover 32 bits of subkey for last two rounds. We have also computed data complexity and success probability for recovering 30 subkey bits accordingly by the differential attack on 16 round PRESENT.
KEYWORDS
Lightweight block cipher, differential cryptanalysis, PRESEN
Graphene Semiconductor Field Effect Transistor
No full textManoj kumar Manimaran's, Isaac Macwan's, and Prabir Patra's poster on a Graphene Semiconductor Field Effect Transistor
Evaluation of filter, paramagnetic and STAGEtips aided workflows for proteome profiling of Symbiodiniaceae dinoflagellate
No full textSupplementary files (Figures and Table
Riluzole But Not Melatonin Ameliorates Acute Motor Neuron Degeneration and Moderately Inhibits SOD1-Mediated Excitotoxicity Induced Disrupted Mitochondrial Ca2+ Signaling in Amyotrophic Lateral Sclerosis
No full textSelective motoneurons (MNs) degeneration in the brain stem, hypoglossal motoneurons (HMNs), and the spinal cord resulting in patients paralysis and eventual death are prominent features of amyotrophic lateral sclerosis (ALS). Previous studies have suggested that mitochondrial respiratory impairment, low Ca2+ buffering and homeostasis and excitotoxicity are the pathological phenotypes found in mice, and cell culture models of familial ALS (fALS) linked with Cu/Zn-superoxide dismutase 1 (SOD1) mutation. In our study, we aimed to understand the impact of riluzole and melatonin on excitotoxicity, neuronal protection and Ca2+ signaling in individual HMNs ex vivo in symptomatic adult ALS mouse brain stem slice preparations and in WT and SOD1-G93A transfected SH-SY5Y neuroblastoma cell line using fluorescence microscopy, calcium imaging with high speed charged coupled device camera, together with immunohistochemistry, cell survival assay and histology. In our experiments, riluzole but not melatonin ameliorates MNs degeneration and moderately inhibit excitotoxicity and cell death in SH-SY5Y(WT) or SH-SY5Y(G93A) cell lines induced by complex IV blocker sodium azide. In brain stem slice preparations, riluzole significantly inhibit HMNs cell death induced by inhibiting the mitochondrial electron transport chain by Na-azide. In the HMNs of brainstem slice prepared from adult (1415 weeks) WT, and corresponding symptomatic SOD1(G93A) mice, we measured the effect of riluzole and melatonin on [Ca2+](i) using fura-2 AM ratiometric calcium imaging in individual MNs. Riluzole caused a significant decrease in [Ca2+](i) transients and reversibly inhibited [Ca2+](i) transients in Fura-2 AM loaded HMNs exposed to Na-azide in adult symptomatic SOD1G93A mice. On the contrary, melatonin failed to show similar effects in the HMNs of WT and SOD1G93A mice. Intrinsic nicotinamide adenine dinucleotide (NADH) fluorescence, an indicator of mitochondrial metabolism and health in MNs, showed enhanced intrinsic NADH fluorescence in HMNs in presence of riluzole when respiratory chain activity was inhibited by Na-azide. Riluzoles inhibition of excitability and Ca2+ signaling may be due to its multiple effects on cellular function of mitochondria. Therefore formulating a drug therapy to stabilize mitochondria-related signaling pathways using riluzole might be a valuable approach for cell death protection in ALS. Taken together, the pharmacological profiles of the riluzole and melatonin strengthen the case that riluzole indeed can be used as a therapeutic agent in ALS whereas claims of the efficacy of melatonin alone need further investigation as it fail to show significant neuroprotection efficacy
A limitation of tachycardia discrimination algorithm in a patient with hypertrophic cardiomyopathy and intermittent complete heart block
No full textRajiv Mahajan, Manoj Kumar Rohit, Ajay Bahl and Kewal K. Talwa
DVFS using clock scheduling for Multicore Systems-on-Chip and Networks-on-Chip
Full text linkA modern System-on-Chip (SoC) contains processor cores, application-specific process-
ing elements, memory, peripherals, all connected with a high-bandwidth and low-latency
Network-on-Chip (NoC). The downside of such very high level of integration and con-
nectivity is the high power consumption. In CMOS technology this is made of a dynamic
and a static component. To reduce the dynamic component, Dynamic voltage and Fre-
quency Scaling (DVFS) has been adopted. Although DVFS is very effective chip-wide,
the power optimization of complex SoCs calls for a finer grain application of DVFS.
Ideally all the main components of an SoC should be provided with a DVFS controller.
An SoC with a DVFS controller per component with individual DC-DC converters and
PLL/DLL circuits cannot scale in size to hundreds of components, which are in the
research agenda. We present an alternative that will permit such scaling. It is possible
to achieve results close to an optimum DVFS by hopping between few voltage levels
and by an innovative application of clock-gating that we term as clock scheduling. We
obtain an effective clock frequency by periodically killing some clock cycles of a master
clock. We can apply voltage scaling for some of the periodic clock schedules which yield
effective clock 1/2, 1/3, . . . By dithering between few voltages we obtain results close to
an ideal DVFS system in simple pipelined circuits and in a complex example, a NoC’s
switch.
Again in the context of a NoC, we show how clock scheduling and voltage scaling can
be automatically determined by means of a proportional-integral loop controller that
keeps track of the network load. We describe in detail its implementation and all the
circuit-level issues that we found. For a single switch, result shows an advantage of up
to 2X over simple frequency scaling without voltage scaling.
By providing each NoC’s switch with our simple DVFS controller, power saving at
network level can be significantly more than what a a global DVFS controller can get.
In a realistic scenario represented by network traces generated by video applications
(MPEG, PIP, MWD, VoPD), we obtain an average power saving of 33%.
To reduce static power, the Power-Gating (PG) technique is used and consists in switching-
off power supply of unused blocks via pMOS headers or nMOS footers in series with such
blocks. Even though research has been done in this field, the application of PG to NoCs
has not been fully investigated. We show that it is possible to apply PG to the input
buffers of a NoC switch. Their leakage power contributes about 40-50% of total NoC
power, hence reducing such contribution is worthwhile. We partitioned buffers in banks
and apply PG only to inactive banks. With our technique, it is possible to save about
40% in leakage power, without impact on performance
Formation and Decay of Exotic Nuclear System using Energy Density Formalism
No full textFinal Report/Executive summaryabstract attachedUniversity Grant Commission, New Delh
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