38 research outputs found
Quantum advantage in zero-error function computation with side information
Get PDFWe consider the problem of zero-error function computation with side information. Alice has a source X and Bob has correlated source Y and they can communicate via either classical or a quantum channel. Bob wants to calculate f(X,Y) with zero error. We aim to characterize the minimum amount of information that Alice needs to send to Bob for this to happen with zero-error. In the classical setting, this quantity depends on the asymptotic growth of χ(G(m)), the chromatic number of an appropriately defined m-instance "confusion graph". In this work we present structural characterizations of G(m) and demonstrate two function computation scenarios that have the same single-instance confusion graph. However, in one case there a strict advantage in using quantum transmission as against classical transmission, whereas there is no such advantage in the other case.This is a preprint from Meng, Ruoyu, and Aditya Ramamoorthy. "Quantum advantage in zero-error function computation with side information." arXiv preprint arXiv:2402.01549 (2024). doi: https://doi.org/10.48550/arXiv.2402.01549. Copyright 2024 The Author. CC BY
Dynamic Characterization of Non-Homogeneous Magnetorheological Fluids Based Multi-Layer Beam
No full textThe vibration properties of multi-layer beam structure comprising axially non-homogeneous magneto-rheological (MR) fluids layer are investigated. The governing equations of a non-homogeneous MR fluids multi-layered beam are formulated using finite element method and Ritz formulation. The validity of the proposed finite element formulations is demonstrated by comparing the results with those obtained from the Ritz formulation. The properties of different configurations of a non-homogeneous MR-fluid beam are evaluated to investigate the influences of the location of the different MR-fluids for various boundary conditions. The properties in terms of natural frequencies and loss factors corresponding to various modes are evaluated under different magnetic field intensities. The effect of location of the fluid treatment on deflection mode shapes is also investigated. The results suggest that the natural frequencies and loss factors of the non-homogeneous MR fluid beams are strongly influenced not only by the intensity of the applied magnetic field, but also by the location of the MR fluids. It is also concluded that the application of non-homogeneous MR fluids could also alter the deflection pattern of the beam, particularly the location of the peak deflection.</jats:p
Mechanical characterization and experimental modal analysis of 3D Printed ABS, PC and PC-ABS materials
No full textAdditive manufacturing (AM) process builds the parts, layer by layer precisely from Computer-Aided Design (CAD) models, whereas traditional subtractive manufacturing process removes layers from materials to attain the desired shape. Of late Rapid prototyped (RP) parts are used for the direct production of components for manufacturing and testing in the industries. Understanding material, machine used along with the process variables that affect the strength of the final part gains importance as the parts can be printed directly from CAD data and effectively integrated into structures. The main aim of this investigation is to present the mechanical characterization and free vibration analysis of various 3D printed Engineering Plastic Materials. Acrylonitrile Butadiene Styrene (ABS), Polycarbonate (PC), and Polycarbonate–Acrylonitrile Butadiene Styrene (PC-ABS) materials are used in this study. Spools are prepared from plastic pellets using wire extruder. Tensile tests have been performed on dog bone specimens to evaluate strength, fractured specimen’s surfaces which are further evaluated using Field Emission Scanning Electron Microscope (FESEM) to explore fracture of the raster and bonding between layers. From the experimental results it’s noticed that the PC-ABS material exhibits improved elastic limit and load-carrying capacity compared with ABS and PC. Three types of beams are fabricated using different materials and modal analysis has been conducted to predict the stiffness of beams in terms of natural frequencies under clamped free (CF) and clamped clamped (CC) end conditions. Higher natural frequencies observed with PC-ABS is compared with the rest of the materials
Vibration Analysis of Carbon Fiber Reinforced Laminated Composite Skin with Glass Honeycomb Sandwich Beam Using HSDT
Get PDFIn this paper, the vibration analysis of uniform laminated composite sandwich beam with a viscoelastic core was studied. The governing equation of motion of the laminated composite sandwich beam has been derived based on higher order shear deformation theory (HSDT) in finite element model (FEM). The developed finite element model has been validated in terms of natural frequencies with the experimental values and the available literature. Various parametric studies have been performed to examine the impact of the core thickness, ply orientation and aspect ratio of the uniform laminated composite sandwich beam in response to free vibration for various boundary conditions. From the results it was concluded that that natural frequencies could be increased with increasing the core thickness and decreased with increasing the aspect ratio.</jats:p
Inference and Parameter Estimation for Diffusion Processes
Get PDFThis thesis has been submitted in fulfilment of the requirements for a postgraduate degree (e.g. PhD, MPhil, DClinPsychol) at the University of Edinburgh. Please note the following terms and conditions of use: • This work is protected by copyright and other intellectual property rights, which are retained by the thesis author, unless otherwise stated. • A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. • This thesis cannot be reproduced or quoted extensively from without first obtaining permission in writing from the author. • The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the author. • When referring to this work, full bibliographic details including the author, title, awarding institution and date of the thesis must be given
Creep-fatigue interaction in a low alloy bainitic steel and an austenitic stainless steel
No full textRestriction data tranferred 2014-07-01T11:31:50-05:00
Original Data
Group with Access UIUC Users [automated]
Release Date: none
Reason: ETDs are only available to UIUC Users without author permissionETDs are only available to UIUC Users without author permissionCreep, fatigue and creep-fatigue tests with five and ten minutes hold time were conducted using smooth and modified keyhole compact tension specimens. Measurements were made of the crack initiation and propagation of a 2 1/4Cr-1Mo steel in the normalized and tempered condition and a 304 stainless steel in the annealed condition at temperature of 565\sp\circC and 650\sp\circC, respectively, in air. Stress redistribution times under creep loading were computed to establish the governing stress field for crack initiation and crack growth using the creep isochronous curves and an analytical solution. Smooth specimen test results were used to predict the crack initiation life under fatigue and creep-fatigue loading using the local strain approach and to predict the total life under creep loading using the reference stress approach. Microstructural analysis was carried out to identify the failure mechanisms.It was found that crack initiation occupied a major portion of the failure life under creep and creep-fatigue loading and that stress redistribution times were two orders of magnitude lower than the crack initiation times. Both materials were identified as creep-ductile, with reference stress-controlled initiation and growth behavior. Creep failure mechanism predominates after short hold times (5 minutes). Creep cavitation was the failure mechanism in 304 stainless steel while exhaustion of matrix ductility with very little creep damage was the dominant failure node for 2 1/4Cr-1Mo steel under creep and creep-fatigue loading.Made available in DSpace on 2011-05-07T14:24:09Z (GMT). No. of bitstreams: 2
license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5)
9011036.pdf: 5950874 bytes, checksum: 8aba479de934033f90dd8b3b2179634d (MD5)
Previous issue date: 1989Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding ([email protected]) on 2011-05-07T15:06:19Z
Item is restricted indefinitely.U of I Onl
Synthesis of small molecule inhibitors targeting signal transduction pathways
Get PDFThe main aim of the study described in this thesis is the development of small molecules as inhibitors targeting signal transduction pathways, thereby treating cancer. We attempted to synthesize compounds based on the hits obtained from high throughput screening of the Chemdiv diversity set compounds. Chapter One is a general introduction to cancer, history of chemotherapeutic drugs and an introduction to signal transduction pathways. The following two chapters briefly introduce the biological targets in the authors study. Chapter Two describes the role of B-cell lymphoma type xL (Bcl-xL), in apoptosis and the development of drugs targeting Bcl-xL. Examples of Bcl-xL drugs relevant to this study have been provided.
Chapter Three introduces Src homology 2 (SH2) domain containing tyrosine phosphatase Shp2, a protein tyrosine phosphatase, as an oncogene, its role in signal transduction pathways and the recent developments in drug development towards the inhibition of this oncogene. Chapter Four gives a general introduction to microwave-assisted organic synthesis and its advantages. This chapter also describes the use of flow reactors in organic synthesis and its advantages. The following two chapters describe the author\u27s own findings. Chapter Five focuses on the design, synthesis and biological evaluation of small molecules as inhibitors of Bcl-xL. Isoquinolinols, NSC-131734 and HL2-100 emerged as lead compounds from high throughput screening for Bcl-xL. Our strategy focused on identifying an isoquinolinol lead with increased potency.
Based on isatin hits obtained earlier through HTS screen and SAR studies in our lab, more isatin derivatives were synthesized focusing on developing inhibitors with increased cell permeability and improved potency
Design of Novel Inhibitors for Infectious Diseases using Structure-based Drug Design: Virtual Screening, Homology Modeling and Molecular Dynamics
No full textThe main aim of the study in this thesis was to use structure-based protocols to design new drugs for enzymes, DXS and DXR in the non mevalonate pathway. Another aim of this study was to identify the dimer interface in E.coli FabH as an allosteric binding site for designing new class of anti-infective drugs. We have attempted to identify potential inhibitors for DXS by docking the NCI Diversity set compounds, compound libraries available from GSK-MMV and St. Jude\u27s Children\u27s research center. FabH dimer interface has been identified as a potential target using SiteMap, Alanine mutagenesis and docking studies.
The first chapter gives an overview of the computational methods. The next two chapters briefly introduce the biological targets in the author\u27s study. Chapter two explains the importance of non-mevalonate pathway in microbes. Different enzymes in the non-mevalonate pathway are discussed and the importance of terpenoids in biological processes and also the use of terpenoids as drugs have been extensively discussed in this chapter. The crystal structures available for DXS and DXR are also discussed. Chapter three brings out the importance of FabH as an anti-infective target. Crystal structure of FabH E.coli is discussed and the importance of FabH as a dimer has been discussed in this chapter.
Chapter 3 describes the methods, homology models generated, and analysis from docking studies. The homology models for PvDXS and PvDXR have been used in this study to identify potential inhibitors. Domain swapping and the structural organization of PvDXS before and after domain swaping are discussed. Identification of domain swaping in PvDXS using entropy changes has been extensively discussed.
Chapter 4 focuses on FabH (Fatty Acid Biosynthesis, enzyme H also referred to as β-ketoacyl-ACP-synthase III) dimer interface as an allosteric target. SiteMap analysis and MD simulations on the FabH monomer and dimer structures revealed the dimer interface as a binding region. Further analyses were done by mutagenesis studies on the Phe87 residue, a key residue at the dimer interface region and validating the results using docking studies. NCI Diversity Set compounds were docked at the dimer interface of FabH, which revealed that compounds NSC91529 and NSC19803 docked best at the dimer interface region with the phenyl ring of both the compound
