2,894 research outputs found
Influence of orotic acid on multistage hepatocarcinogenesis in the rat: resistance of hepatocytes from nodules to the mitoinhibitory effects of orotic acid.
No full textRibonucleotide reductase: a possible target for orotic acid induced mitoinhibition in normal hepatocytes in primary culture
No full textIn vitro and in vivo response of hepatocytes from hepatic nodules to the mitoinhibitory effects of phenobarbital.
No full textNarayanella, a new name for Narayana Subba Rao (hymenoptera : mymaridae)
No full textThe name Narayana was applied (Subba Rao, 1976) to a genus erected for the new species N. pilipes reared from the gaUs of Lagerstoemia flos reginae. Unfortunately the author overlooked the vulid and prior use of Narayana by Distant (1908). Narayana Distant was erected with rusticitatus as type-species (Issidae: Homoptera). Hence Narayana Subba Rao is a junior homonym which has to be replaced according to the rules of the International Zoological Nomenclature
Effect of beta-carotene on the expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase in rat liver
No full textResistance of hepatic nodules to orotic acid-induced accumulation of uridine nucleotides.
No full textUltraviolet Radiation-induced Skin Damage and Carcinogenesis: Preclinical Efficacy of Camellia sinensis (Tea)
No full textRadioprotective potential of mint: A brief review
No full textRadiation is an important modality in cancer treatment and estimates
are that between one third and one half of all patients will require
ionizing irradiation therapy during some point in their clinical
management. However, the radiation-induced damage to the normal tissues
restricts the therapeutic doses of radiation that can be delivered to
tumors and thereby limits the effectiveness of the treatment. The use
of chemical compounds (radioprotectors) represents an obvious strategy
to improve the therapeutic index in radiotherapy. However, most of the
synthetic radioprotective compounds studied have shown inadequate
clinical application owing to their inherent toxicity and high cost.
These observations necessitated a search for alternative agents that
are less toxic and highly effective. Studies in the recent past have
shown that some medicinal plants possess radioprotective effects. Two
species of the commonly used aromatic herb mint, Mentha piperita and M.
arvensis protected mice against the γ-radiation-induced sickness
and mortality. Detail investigations have also shown that the aqueous
extract of M. piperita protected the vital radiosensitive organs: the
testis, gastrointestinal and hemopoetic systems in mice. The
radioprotective effects are possibly due to free radical scavenging,
antioxidant, metal chelating, anti-inflammatory, antimutagenic, and
enhancement of the DNA repair processes. This review for the first time
summarizes the observations and elucidates the possible mechanisms
responsible for the beneficial effects. The lacunae in the existing
knowledge and directions for future research are also addressed
Sandalwood Oil and Turmeric-Based Cream Prevents Ionizing Radiation-Induced Dermatitis in Breast Cancer Patients: Clinical Study
No full textBackground: The primary objective of this study was to ascertain the benefit of Vicco turmeric Ayurvedic cream (VTC; Vicco Laboratories, Mumbai, India) sandalwood oil and turmeric-based cream in preventing radiodermatitis in women undergoing curative radiotherapy for their breast cancer. Methods and Materials: The study was an investigator-blinded randomized study with Johnsons Baby Oil (JBO; Johnson & Johnson Ltd., Baddi, India) as a comparator, administered daily from the start of radiation therapy for 5 weeks in women receiving breast radiation therapy, 50 Gy in 2 Gy fractions daily for 5 weeks. The endpoints were to ascertain the delay in the appearance and the degree of severity of dermatitis throughout the study period in accordance to the Therapy Oncology Group (RTOG) score. Results: The results indicated that the topical application of VTC delayed and mitigated the radiodermatitis. When compared to the Johnson’s Baby Oil, a significant decrease (p = 0.025) in the incidence of grade 1 was seen at week two, and also in grade 2 and 3 at week 3 (p = 0.003) and week 4 (p = 0.02), respectively, in the VTC cohort. A concomitant decrease in the average severity was also observed at week 2 (p = 0.02), week 3 (p = 0.05) and week 4 (p = 0.03). Conclusions: The results indicate that VTC cream significantly reduces radiation dermatitis when applied to the breast during and after radiation therapy. The result of this study indicates the beneficial effects. Double blind randomized control studies are required to further confirm the beneficial effects of VTC in mitigating radiodermatitis is people undergoing radiation treatment for their cancer
Radioprotective potential of mint: A brief review
No full textRadiation is an important modality in cancer treatment and estimates
are that between one third and one half of all patients will require
ionizing irradiation therapy during some point in their clinical
management. However, the radiation-induced damage to the normal tissues
restricts the therapeutic doses of radiation that can be delivered to
tumors and thereby limits the effectiveness of the treatment. The use
of chemical compounds (radioprotectors) represents an obvious strategy
to improve the therapeutic index in radiotherapy. However, most of the
synthetic radioprotective compounds studied have shown inadequate
clinical application owing to their inherent toxicity and high cost.
These observations necessitated a search for alternative agents that
are less toxic and highly effective. Studies in the recent past have
shown that some medicinal plants possess radioprotective effects. Two
species of the commonly used aromatic herb mint, Mentha piperita and M.
arvensis protected mice against the γ-radiation-induced sickness
and mortality. Detail investigations have also shown that the aqueous
extract of M. piperita protected the vital radiosensitive organs: the
testis, gastrointestinal and hemopoetic systems in mice. The
radioprotective effects are possibly due to free radical scavenging,
antioxidant, metal chelating, anti-inflammatory, antimutagenic, and
enhancement of the DNA repair processes. This review for the first time
summarizes the observations and elucidates the possible mechanisms
responsible for the beneficial effects. The lacunae in the existing
knowledge and directions for future research are also addressed
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