61 research outputs found
George MacLeod’s open-air preaching: performance and counter-performance
No full textStuart Blythe uses the methodology of performance to analyse George MacLeod’s open-air preaching. He points out that MacLeod’s preaching was derived from a theology of the incarnation, and an understanding of the paradoxes and dichotomies of common human life. This preaching, Blythe suggests, was also a counter-performance in the context of outlooks and ideologies inimical to the gospel. The paper raises interesting issues related to preaching as performance, and the further question as to whether or not the life and work of the Church as a whole might now be better understood as a counter-performance.Publisher PD
DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire
No full textThe majority of known human tumor-associated antigens derive from non-mutated self proteins. T cell tolerance, essential to prevent autoimmunity, must therefore be cautiously circumvented to generate cytotoxic T cell responses against these targets. Our strategy uses DNA fusion vaccines to activate high levels of peptide-specific CTL. Key foreign sequences from tetanus toxin activate tolerance-breaking CD4+ T cell help. Candidate MHC class Ibinding tumor peptide sequences are fused to the C terminus for optimal processing and presentation. To model performance against a leukemia-associated antigen in a tolerized setting, we constructed a fusion vaccine encoding an immunodominant CTL epitopederived from Friend murine leukemia virus gag protein (FMuLVgag) and vaccinated tolerant FMuLVgag-transgenic (gag-Tg) mice. Vaccination with the construct induced epitopespecificIFN-c-producing CD8+ T cells in normal and gag-Tg mice. The frequency and avidity of activated cells were reduced in gag-Tg mice, and no autoimmune injury resulted. However, these CD8+ T cells did exhibit gag-specific cytotoxicity in vitro and in vivo. Also, epitope-specific CTL killed FBL-3 leukemia cells expressing endogenous FMuLVgag antigen and protected against leukemia challenge in vivo. These results demonstrate a simple strategy to engage anti-microbial T cell help to activate epitope-specific polyclonal CD8+ T cell responses from a residual tolerized repertoire
Anxiety Of Alexandra Maria Ellena Delgado In Stuart Gillard’s The Cutting Edge: A Psychoanalytic Approach
Get PDFThe major problem of this study is how anxiety reflected in the major character’s personality. The aim of this study is to analyze Stuart Gillard’s The Cutting Edge the structural elements and the development of personality of the major character based on Psychoanalytic Approach. This study focuses on major character, namely Alexandra Maria Ellena Delgado. The benefit of this research is to give addition all information to be used by other literature researchers who are interested in analyzing this movie. This study uses two data source, namely primary and secondary data source. The primary data source is the play script itself, while the secondary data are taken from some information needed.The method of data collection is qualitative method. Based on the analysis, the study of this research comes from
the major character problem. It purposes to analyze the movie using individual psychologycal perspective. The steps to conduct this research are (1) determining the type of the study, (2) determining the object of the study, (3) determining the data and data sources, (4) determining the technique of data collection, and (5) determining technique of data analysis. The result of the study found that there is a relationship between The Cuttingedge movie and psychoanalytic approach, first on the structural element of the movie; where the message to The Cuttingedge movie shows that Alexandra Maria Ellena Delgado as the major character that she want to be a beautiful ice skater. The point of view is, the director wants to show the struggle of life of Delgado’s. The theme of the movie is the basic idea of story in which the author portrays through conflicts of characters with other character or with life events. The anxiety of Alexandra related with psychoanalytic approach is that the doubt, fear, and worried of Alexandra makes her brave to take the second chance, and make her dream
comes true namely to be a beautiful ice skater
Libertad de expresión: la perspectiva de John Stuart Mill
Get PDFEl presente trabajo tiene como propósito analizar el concepto de libertad de expresión en el pensamiento filosófico de John Stuart Mill. El estudio se centra en la formulación y argumentación que lleva a cabo el autor en el ensayo “Sobre la libertad”, texto que ha sido reconocido como uno de los pilares fundamentales del pensamiento político liberal. Se aborda el estudio del principio de libertad, concebido por Mill como una barrera necesaria incluso en las democracias representativas, con el fin de fijar límites al poder de coacción del estado y de la sociedad sobre el individuo. Como una derivación del principio de libertad, emerge la libertad de pensamiento y discusión –o libertad de expresión- la que de acuerdo con Mill representa una base sólida para el descubrimiento de la verdad y el progreso en el debate público. Se incluye un análisis de la crítica de Martha Nussbaum sobre la supuesta excesiva amplitud que implica el concepto de libertad de expresión en Mill, y se argumenta que el concepto que Mill defiende no es tan ilimitado como esta pensadora lo supone. El trabajo plantea la hipótesis de que si bien Mill hizo un esfuerzo muy valioso para fijar la frontera entre la libertad y la autoridad, a través de la noción del “daño”, éste no alcanza a lograr su cometido, debido a la ambigüedad o vaguedad misma del concepto, que le hace susceptible de múltiples interpretaciones subordinadas a intereses subjetivos.The purpose of this paper is to analyze the concept of freedom of expression in the philosophical thought of John Stuart Mill. The study focuses on the formulation and argumentation carried out by the author in the essay "On Liberty", a text that has been recognized as one of the fundamental pillars of liberal political thought. The study of the principle of freedom is addressed, conceived by Mill as a necessary barrier even in representative democracies, in order to set limits to the coercive power of the state and society over the individual. As a derivation of the principle of freedom, freedom of thought and discussion –or freedom of expression- emerges, which according to Mill represents a solid basis for the discovery of truth and progress in public debate. An analysis of Martha Nussbaum's criticism of the alleged excessive breadth implied by the concept of freedom of expression in Mill is included, and it is argued that the concept that Mill defends is not as unlimited as this thinker supposes. The work proposes the hypothesis that although Mill made a very valuable effort to establish the border between freedom and authority, through the notion of "harm", it does not achieve its goal, due to ambiguity or vagueness of the concept itself, which
makes it susceptible to multiple interpretations subordinated to subjective interests.TABLA DE CONTENIDO
PRÓLOGO 5
1. LA NECESIDAD DE UN PRINCIPIO. La autoridad y la libertad 13
1.1. La tiranía de la mayoría 20
1.2. El principio de libertad 23
1.3. El papel del “daño” en el principio de la libertad 26
2. LA LIBERTAD DE EXPRESIÓN. Consideraciones preliminares 35
2.1. La defensa de la libertad de expresión: la perspectiva gnoseológica 38
2.2. El énfasis está ¿en el oyente o en el hablante? 49
3. ¿TODO VALE? Los límites de la libertad de expresión 53
3.1. La mirada crítica de Martha Nussbaum 60
REFERENCIAS BIBLIOGRÁFICAS 69MaestríaMagíster en Filosofí
Convenient Creation and Use of Suturing Supplies for Laparoscopic Partial Nephrectomy
Get PDFAbstract The closure of the renal defect is the most challenging part of laparoscopic partial nephrectomy when suturing is required. The author presents a method of creating and using suturing material for laparoscopic partial nephrectomy that has been developed over several hundred cases at the author's institution. These techniques can be used to simplify the task of suturing during laparoscopic partial nephrectomy.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/78109/1/end.2009.0006.pd
Central and peripheral determinants of fatigue in acute hypoxia
No full textThis thesis was submitted for the degree of Docter of Philosophy and awarded by Brunel University on 24th March 2011.Fatigue is defined as an exercise-induced decrease in maximal voluntary force produced by a muscle. Fatigue may arise from central and/or peripheral mechanisms. Supraspinal fatigue (a component of central fatigue) is defined as a suboptimal output from the motor cortex and measured using transcranial magnetic stimulation (TMS). Reductions in O2 supply (hypoxia) exacerbate fatigue and as the severity of hypoxia increases, central mechanisms of fatigue are thought to contribute more to exercise intolerance. In study 1, the feasibility of TMS to measure cortical voluntary activation and supraspinal fatigue of human knee-extensors was determined. TMS produced reliable measurements of cortical voluntary activation within- and between-days, and enabled the assessment of supraspinal fatigue. In study 2, the mechanisms of fatigue during single-limb exercise in normoxia (arterial O2 saturation [SaO2] ~98%), and mild to severe hypoxia (SaO2 93-80%) were determined. Hypoxia did not alter neuromuscular function or cortical voluntary activation of the knee-extensors at rest, despite large reductions in cerebral oxygenation. Maximal force declined by ~30% after single-limb exercise in all conditions, despite reduced exercise time in severe-hypoxia compared to normoxia (15.9 ± 5.4 vs. 24.7 ± 5.5 min; p < 0.05). Peripheral mechanisms of fatigue contributed more to the reduction in force generating capacity of the knee-extensors following single-limb exercise in normoxia and mild- to moderate-hypoxia, whereas supraspinal fatigue played a greater role in severe-hypoxia. In study 3, the effect of constant-load cycling exercise to the limit of tolerance in hypoxia (SaO2 ~80%) and normoxia was investigated. Time to the limit of tolerance was significantly shorter in hypoxia compared to normoxia (3.6 ± 1.3 vs. 8.1 ± 2.9 min; p < 0.001). The reductions in maximal voluntary force and knee-extensor twitch force at task-failure were not different in hypoxia compared to normoxia. However, the level of supraspinal fatigue was exacerbated in hypoxia, and occurred in parallel with reductions in cerebral oxygenation and O2 delivery. Supraspinal fatigue contributes to the decrease in whole-body exercise tolerance in hypoxia, presumably as a consequence of inadequate O2 delivery to the brain
Seizing "Hagoromo": Ezra Pound's imaged drama and "The Cantos".
No full text"Seizing Hagoromo: Ezra Pound's Imaged Drama called The Cantos" presents a two-pronged analysis of Pound's relationship with the Japanese Noh drama that began with his acquisition of the philosopher Ernest Fenollosa's notes in late 1913. First, this dissertation demonstrates the influence that Noh drama itself had on Pound's early thinking, particularly in enabling him to move from the brief encapsulations of his Imagist poetry such as In a Station of the Metro, to the more dynamic, paradoxical, Vorticism that directly preceded his initial attempts at The Cantos. Second, Pound's experiences with the Noh form itself are examined, both in his edition of Fenollosa's translations of Noh plays, and in Pound's own newly published attempts at the form, which date from 1916. In the Introduction, the concept of "Imaged Drama" is explained by discussing Euripides' Bacchae. Imaged drama refers to the arena in which an audience combines elements of what the semiotician Keir Elam labels "dramatic" and "performance" texts. In an audience's "imaged text" both the dramatic and performance texts are simultaneously present, yet neither prevails. Chapter One introduces the Noh form in Fenollosa's and Pound's translations by discussing Suma Genji. Chapter Two indicates the impact that Noh drama had on Pound's theoretical move from Imagism to Vorticism. Chapter Three identifies the Noh play Hagoromo in its Poundian context. Chapter Four presents a comparison of three different Noh plays: Zeami's Nishikigi, Pound's Tristan, and Yeats's At the Hawk's Well. Chapter Five presents a reading of The Cantos in the light of the foregoing discussion of Hagoromo and the Noh drama. Chapter Six returns to the Greek stage by analyzing Pound's translation of Sophocles' Women of Trachis, which Pound felt could only be performed effectively by a Noh troupe. Although Pound knew no Japanese and knew even less of the Japanese Noh drama when he received Fenollosa's notes, he quickly adapted several of Noh's dramatic conventions to his emerging style of longer poetry. Ezra Pound "seized" Hagoromo from Japan and with it, he created a style of dynamic poetry as heavily allusive and rigorous as the Noh itself, without ever seeing a Noh performance. (Abstract shortened with permission of author.)PhDComparative literatureAmerican literatureAsian literatureTheaterUniversity of Michiganhttp://deepblue.lib.umich.edu/bitstream/2027.42/161842/1/8812958.pd
Functionalised metal-organic frameworks: a novel approach to stabilising single metal atoms
Get PDFWe have investigated the potential of metal-organic frameworks for immobilising single atoms of transition metals using a model system of Pd supported on NH2-MIL-101(Cr). Our Transmission Electron Microscopy and in-situ Raman spectroscopy results give evidence for the first time that functionalised metal-organic frameworks may support, isolate and stabilise single atoms of palladium. Using Thermal Desorption Spectroscopy we were able to evaluate the proportion of single Pd atoms. Furthermore, in a combined theoretical-experimental approach, we show that the H-H bonds in a H2 molecule elongate by over 15% through the formation of a complex with single atoms of Pd. Such deformation would affect any hydrogenation reaction and thus the single atoms supported on metal-organic frameworks may become promising single atom catalysts in the future
Circulating Precursor CCR7(lo)PD-1(hi) CXCR5(+) CD4(+) T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure
No full textFollicular B helper T (Tfh) cells support high affinity and long-term antibody responses. Here we found that within circulating CXCR5(+) CD4(+) T cells in humans and mice, the CCR7(lo)PD-1(hi) subset has a partial Tfh effector phenotype, whereas CCR7(hi) PD-1(lo) cells have a resting phenotype. The circulating CCR7(lo)PD-1(hi) subset was indicative of active Tfh differentiation in lymphoid organs and correlated with clinical indices in autoimmune diseases. Thus the CCR7(lo)PD-1(hi) subset provides a biomarker to monitor protective antibody responses during infection or vaccination and pathogenic antibody responses in autoimmune diseases. Differentiation of both CCR7(hi)PD-1(lo) and CCR7(lo)PD-1(hi) subsets required ICOS and BCL6, but not SAP, suggesting that circulating CXCR5(+) helper T cells are primarily generated before germinal centers. Upon antigen reencounter, CCR7(lo)PD-1(hi) CXCR5(+) precursors rapidly differentiate into mature Tfh cells to promote anti-body responses. Therefore, circulating CCR7(lo)PD-1(hi) CXCR5(+) CD4(+) T cells are generated during active Tfh differentiation and represent a new mechanism of immunological early memory
Identity and consumption practices of Northamptonshire Caribbeans c.1955-1989
No full textThe objective of this thesis is to delineate and analyse Northamptonshire Caribbeans' consumption c.1955-1989. Author-collected and other oral histories alongside complementary primary and secondary references dovetail to unearth and analyse aspects of Post-War Caribbean consumption in a British provincial location that have been significantly unexplored previously. Central to the argument is the contention that identity is fundamentally significant in comprehending and analysing Northamptonshire Caribbeans' consumption. Various conceptualisations of identity facilitated development of consumer materialisations and aspirations. This thesis explores how multiple forms of identity as Caribbean, Black and British people were significant in shaping local Caribbeans' consumption. The succeeding pages address and analyse how these multiple identities influenced consumption and how provincial consumer behaviour was shaped by Caribbeans' relative co-ethnic isolation in Northamptonshire. Chapter 3 delineates and analyses consumer practices and practicalities of Northamptonshire Caribbeans. Integral within these consumer practices and practicalities are changes in consumption over time, intergenerational differences in consumption, as well as aspects of consumption that could be considered 'typical' and/or 'atypical' Northamptonshire Caribbean consumption; all of which are incorporated within this chapter. Chapter 4 connects identity and consumption through enhancing understanding of Northamptonshire Caribbeans' consumer networks. These networks interacted with the combination of identities local Caribbeans psychologically felt part of within various Caribbean, Black and British permutations. Furthermore, such identities varied more widely amongst the younger generation than their co-ethnic elders, a concept which is also addressed. Education and cultural currency are two novel strands through which to analyse connections between consumption and identity. The final two chapters deploy these concepts in an innovative manner creating and developing greater understanding of Northamptonshire Caribbeans' consumption. Chapter 5 expounds on the concept that education can be used as consumption whilst shaping future consumer behaviour, both ideas significantly under-explored previously. Chapter 6 introduces the theory of cultural currency, the idea that aspects of culture have finite, but changing, values and must be shared to have value similar to monetary currencies having exchange values for other monetary currencies. This chapter demonstrates how Northamptonshire Caribbeans shared aspects of Caribbean culture as cultural currency, fostering co-ethnic strength whilst gaining inter-ethnic respect for Caribbeans. Through comprehending Caribbean identity, correlations between empirical and social history, local consumption, as well as educational and cultural circumstances that stimulated and inspired Northamptonshire Caribbeans, this thesis distinctively illuminates how local Caribbeans' consumption interacted with various permutations of Afro-Caribbean, Black and/or British identities whilst representing idiosyncratic local nodes within these larger amalgamations
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