1,721,079 research outputs found
Letter by Mangiacapra and Barbato regarding article, "Effects of endothelial dysfunction on residual platelet aggregability after dual antiplatelet therapy with aspirin and clopidogrel in patients with stable coronary artery disease".
No full textMicrovascular impairment associated with percutaneous coronary revascularization: The quest for protective microcirculatory strategies
No full textNo abstract availabl
Endothelial dysfunction in patients with spontaneous coronary artery dissection: another brick in the failing coronary wall?
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From SYNTAX to FAME, a paradigm shift in revascularization strategies: the key role of fractional flow reserve in guiding myocardial revascularization.
No full textThrombus aspiration in primary percutaneous coronary intervention: Still a valid option with improved technique in selected patients!
No full textIndividual variability of response to antiplatelet therapy is an important determinant of adverse clinical outcome
No full textDual antiplatelet therapy with aspirin (acetylsalicylic acid) and clopidogrel is widely used in order to prevent recurrent ischaemic events in patients undergoing percutaneous coronary intervention. The goal is to achieve an optimal platelet inhibition, providing clear clinical benefit in most patients. However, a wide inter-individual variability exists in the response to antiplatelet drugs. Several factors, such as genetic, cellular and clinical factors, may contribute to determine fluctuation in platelet reactivity even within the individual patient. Patients with high post-treatment platelet reactivity are at higher risk of ischaemic events in both the short term (during or shortly after percutaneous coronary intervention) and the long term. Several methodologies and devices have been developed to monitor individual response to antiplatelet treatment assessing different pathways of platelet activation and aggregation. In these patients, more aggressive antithrombotic strategies and new generation drugs may be beneficial in order to reduce ischaemic complications after percutaneous coronary intervention. © 2010 Adis Data Information BV. All rights reserved
Lack of correlation between platelet reactivity and glycaemic control in type 2 diabetes mellitus patients treated with aspirin and clopidogrel.
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