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Strategie retoriche e influenze declamatorie nell'ottavo libro del Bellum civile di Lucano
No full text
Method for reducing the resistance to anticancer drugs, radioresistance and cancer stem cells formation and metastatic phenotype
No full textThe present invention relates to the use of systems involved in ROS generation (reactive oxygen species) to reduce resistance to chemotherapy and radiation therapy, reduce cancer stem cell formation and inhibit the metastatic phenotype; the subject matter of the invention further relates to inhibitors of ROS generation serving to reduce resistance to chemotherapy and radiation therapy and inhibit cancer stem cell formation and inhibit the metastatic phenotype
Caccia alle streghe: anacronismi e ideologia imperiale nell'ottavo libro del Bellum Civile di Lucano
No full textISOLATED GENETICALLY MODIFIED CELL POPULATION
No full textThe present invention concerns an isolated population of cells characterized by the fact that (I) they comprise at least one exogenous RNA, (II) have the PHD-2 gene inducible silenced, and / or (IlIa) have the UQCRB gene inducible silenced or (IIIb) have the SIRT3 gene inducible overexpressed or (IIIC) have one or more of the following systems modulated by the use of inhibitors or inducers: SOD1 / SOD2 / SOD3 (superoxide dismutase 1 -3), Nrf2 / keepl1 (NF-E2-related transcription factor 2), CAT (catalase), Grx (glutathione-glutaredoxin system), PGC-1α (peroxisome proliferator-activated receptor gamma coactivator 1 alpha) FoxOS (forkhead box protein family), Trx (thioredoxin system), NOX-DUOXs (NADPH oxidase family), phox family PRXs (peroxiredoxins), MPO (myeloperoxidase), glutathione peroxidase (GPx); optionally (IV) they include at least one suicide gene, and / or (V) have the gene HIF-1 alpha silenced. This isolated population of cells is useful in the treatment of tissue damage, degenerative diseases, inflammatory and immune disorders, bacterial infections, in gene therapy, in the treatment of viral diseases and tumors. A method for producing said isolated population of cells is a further object of the invention
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