113 research outputs found
Expanding horizons in the treatment of mantle cell lymphoma: Ibrutinib a novel BTK-targeting inhibitor
No full textMantle cell lymphoma (MCL) is a non-Hodgkin lymphoma characterized by involvement of the lymph nodes, spleen, blood, and bone marrow with short remission duration to standard therapies and a median overall survival of 4–5 years. Small molecule inhibitors targeting dysregulated pathways (MAPK/ERK, PI3K/PKB/mTOR, JAK/STAT) have significantly improved clinical outcomes in cancer patients. Recently Bruton’s tyrosine kinase (BTK), a crucial terminal kinase enzyme in the B-cell antigen receptor (BCR) signaling pathway, has emerged as an attractive target for therapeutic intervention in human malignancies and autoimmune disorders. Ibrutinib, a novel first-in-human BTK-inhibitor, has demonstrated clinical effectiveness and tolerability in clinical trials, recently been approved by FDA in the treatment of MCL.
Metal Organic Frameworks for Gas-phase Capacitive Sensing
No full textOLD ChemE/Organic Materials and Interface
Dapagliflozin: a new adjunct in the treatment of Type 2 diabetes mellitus
No full textDiabetes mellitus (DM) Type 2 is a metabolic disorder that is characterized by high blood glucose in the context of insulin resistance and relative insulin deficiency. The classic symptoms are excess thirst, frequent urination, and constant hunger. Management of Type 2 diabetes focuses on lifestyle interventions, lowering other cardiovascular risk factors, and maintaining blood glucose levels in the normal range. There are several classes of anti-diabetic medications available and these include sulfonylureas, nonsulfonylurea secretagogues, alpha glucosidase inhibitors, thiazolidinediones, glucagon-like peptide-1 analog, and dipeptidyl peptidase-4 inhibitors. Recently, dapagliflozin (Farxiga™), a sodium-glucose cotransporter 2 inhibitor has been approved by Food and Drug Administration as an adjunct to diet and exercises to improve glycemic control in adults with Type 2 DM
Agricultural trade liberalization in the Uruguay Round : one step forward, one step back?
No full textAfter evaluating the Uruguay Round's impact on agriculture and border protection in the next decade, the author concludes that while there was significant reform of the rules - particularly the conversion of nontariff barriers into tariffs and the reduction and binding of all tariffs - in practice, trade will probably be liberalized less than expected. The objective of the Round was to reverse protectionism and remove trade distortions. This may not be achieved in practice, at least not until further reductions are carried out in future rounds of negotiations. The major exception to this conclusion is in high-income Asian countries, where protection for major commodities will be significantly reduced. The tariffication and binding of all tariffs on agricultural products represents a significant step forward. Liberalization is implicit because countries are prohhibited from arbitrarily raising tariffs to new higher levels. But many of the newly established tariffs are so high in many countries as to effectively prohibit trade. Patterns of liberalization vary considerably by commodity and by country. Generally, the extent of liberalization was diminished by binding tariffs to the base period of 1986-88, when border protection was at a high point. In most OECD countries, this was worsened by"dirty tariffication:"the new base tariffs offered even greater protection than the nontariff barriers they replaced. Even after the commitments to tariff reductions in the Round, the ad valorem measure of the final binding tariffs will remain higher than the average rate of protection in 1982-93. A number of developing countries in East Asia, Latin America, and the Middle East chose to lock in prior liberalization efforts on some products. But for most commodities, there will be little actual liberalization, since most developing countries chose to bind their tariffs at a maximum level. Even when countries reduced already-bound rates, bound tariffs remained significantly higher than current applied rates, giving countries the flexibility to raise tariffs later. The high level of bound tariffs may allow countries to apply variable tariffs below the bound level, thus failing to stabilize tariffs and improve market access. Moreover, the Round did not touch many of the worst distortions in developing countries, such as import subsidies, export taxes, state-trading monopolies, and domestic policies that implicitly tax agriculture.Trade Policy,Environmental Economics&Policies,Economic Theory&Research,Export Competitiveness,Rules of Origin,Trade Policy,Rules of Origin,TF054105-DONOR FUNDED OPERATION ADMINISTRATION FEE INCOME AND EXPENSE ACCOUNT,Environmental Economics&Policies,Economic Theory&Research
Design of Low-Threshold Comparator for Improved Timing-Resolution Analog/Digital SiPM
No full textCoincidence time resolution (CTR) in time-of-flight (TOF) positron emission tomography (PET) determines the signal-to-noise ratio (SNR) in iterative image reconstruction algorithms. In PET detectors, the photodetector's single-photon timing resolution (SPTR) influences the CTR by adding uncertainty to the single photoelectron time-of-arrivals. This effect can be modelled as the convolution of the scintillation pulse shape function and the total photodetector jitter at single-photon level, before following an order statistics process. Particularly in Cherenkov-based PET detectors, SPTR has a direct impacton the CTR due to the low number of detected photons. In this thesis, the research is focussed on the design of low thresh-old comparators for two specific purposes in PET. Firstly, the design of in-pixel (SPAD-cell) low-threshold comparator that improves SPAD jitter at the pixel level, since it allows the detection of photo-electron triggered avalanche at the earliest possible time, thus minimizing statistical fluctuations. The design is targeted for Cherenkov-based PET, where improvement in SPTR directly results in improvement of CTR. Secondly, for the integration of analog silicon photomultiplier (A-SiPM) on-chip. Such integration helps in realizing a high Photon Detection Effciency (PDE) and low Dark Count Rate (DCR) A-SiPM with integrated readout electronics. A high speed comparator with a direct connection to the fast terminal of A-SiPM has been realized.Electrical Engineering | Microelectronic
Sachdeva’s Ark: The imminent deluge of space crimes
No full textDeviation from accepted social standards of living has been a concern since the inception of society. Society, through its laws, has set a threshold of deviations, the crossing of which, whatsoever be the motivation for such imprudence, becomes behaviour that warrant attention and correction. G S Sachdeva, the author of the book under review, echoes this social truth about human nature, in the same vein and grandeur as David Hume, at the outset of his exposition, ‘Humans are after all human and wherever they go (…) And under stress or provocation, these [their human instincts] may burst open, criminally’ (p. vii). Does Sachdeva maintain this Humeanist elegance and eloquence that he displays at the start of his discourse through the rest of the book? In fact, Sachdeva, of everything he is and he is not, is thoroughly philosophical in his approach to things, which manifests as an irresistible desire to explore meanings and to provide explanations for the same. That perhaps qualifies him as a Humeanist
Effect of the optimisation time interval on the performance of mobile networks
No full textThis thesis project researches the effect of the optimisation time interval on the performance of a self-optimised mobile network. The goal of the thesis is to ascertain if there exists an optimal time interval for the self-optimisation of the KPN network, and what that interval is. In order to research this question, the project uses data from the KPN network as input, and sets up a simulation study in MATLAB. Two areas in the Netherlands are considered in this study – Friesland and Purmerend. The self-optimisation of the network is carried out through the modification of three optimisation parameters – antenna tilt, RS power, and Cell Individual Offset. The scope of the study is limited to LTE in the downlink, for the 800 MHz band. The bandwidth used in this study is 10 MHz. The performance of the mobile network has been studied using KPIs such as 10th throughput percentile, coverage failure rate, call drop rate, and load. In the end, the study analyses the results for each area, for the self-optimisation carried out by modifying the three parameters over several different optimisation time intervals, and discusses their impact on the performance of the network. A comparison has also been drawn between the performance of a self-optimised network and an un-optimised network, to highlight the gains achieved with SON. Finally, recommendations are made regarding a suitable time interval, and a relative comparison between suitability of the three optimisation parameters has been drawn. The study finds that a suitable time interval for optimisation does exist, and is 240 minutes, for both the simulation areas. The study finds RS power to be the most suitable parameter for self-optimisation, in both the areas. However, the research runs into some unexpected results with respect to the optimisations using tilt angle, and has been discussed in detail in the report. Significant gains are observed with SON, as compared to the case of ‘No SON’ or an un-optimised network. Electrical Engineering | Network Architectures and Service
Techno-Economic feasibility analysis of Solid-Oxide Fuel Cell-Gas Turbine based hybrid propulsion system fueled by Hydrogen: How a Solid-Oxide Fuel Cell can impact the performance of the propulsion system and the economics of the aircraft
No full textThe world is moving towards sustainability and there is immense pressure on Aerospace Industry to reduce its emissions to contribute to a carbon-neutral world. However, maturing gas turbine technology is a big bottleneck towards this goal and hence, this project focuses on the technical and economic feasibility of a new type of propulsion system, called Solid-Oxide Fuel Cell- Gas Turbine or SOFC-GT hybrid propulsion system. SOFC- GT, even though being a low TRL technology, has the potential to reduce fuel consumption, emissions, and operation costs, making it a suitable candidate for a future propulsion system.This research concludes that in order to achieve the full potential of the SOFC-GT hybrid, engine parameters like BPR, FPR and cooling air requirements need to be changed. The Thrust-Specific Fuel Consumption (TSFC) for the propulsion system has decreased by 6.03% and 19.89% for 1 MW and 4 MW fuel cell power output in Off-Design (Cruise) condition. Along with this, core mass flow rate or size, cooling air requirement and Turbine Inlet Temperature for Cruise condition has decreased. The emission results show that the NOx emissions have been reduced by 29.11% and 78.05% respectively. Sensitivity analysis shows that the thermodynamic efficiency is most sensitive to engine parameters but the impact of fuel cell parameters is increasing as the fuel cell power output is increased. The economic analysis done in this study shows that the SOFC-GT hybrid is not feasible for the commercially available fuel cell because of the substantial increase in weight of the propulsion system. However, the propulsion system will become feasible at the fuel cell system specific power of 2.30 kW/kg and 2.10 kW/kg for no emission tax and highest emission tax scenario respectively at a fuel price of $ 6/kg. Along with this, increasing the fuel cell power output leads to the increase in required specific power for fuel cell or has a negative impact on the overall economics. The overall economics of the aircraft is most sensitive to aircraft parameters but increasing the fuel cell power output decreases sensitivity substantially. In the end, the emission has a low impact on the overall economics of the aircraft. This research shows that it is possible to integrate a SOFC with the turbofan if the fuel cell technology improves in the future. Along with this, the research provides multiple novel methodologies for technical and economic analysis of the SOFC-GT hybrid.Aerospace Engineering | Flight Performance and Propulsio
Detection and Tracking of a Fast-Moving Object in Squash using a Low-Cost Approach
No full textAdvancement in technology has given rise to the need for technology to be utilized in extracting meaningful game-play information from sports. To do so in a ball-game like squash, the prime objective is to perform ball-tracking in an adequate and efficient manner. In squash, ball-tracking is complex due to the small size of the ball, the high-speed movement and constant occlusion due to the continuous movement of the players. The current state-of-the-art ball tracking methods use high-speed cameras along with high-computation power resources to solve these problems in similar sports such as tennis. The aim of this thesis is to solve the challenges in ball-tracking for squash using a low-cost approach with low-computation power resources and a single camera view. A ball-detection system with a high-accuracy and a ball-tracking system which can optimally tackle the problem of occlusion is developed using computer-vision techniques and by utilizing the cues from the game itself. The implementation is carried out on a Raspberry-Pi which is characterized as a low-computation platform with an Arm Cortex-A53 processor. The results show that the tracking-problem can be solved using a low-cost approach for the challenging scenarios that are present in squash. The 2D trajectory of the ball generated as a result can be used for various applications such as line-calling, shot analysis and game analysis.Electrical Engineering | Embedded System
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