1,721,018 research outputs found
The impact of brain lesion characteristics and the corticospinal tract wiring on mirror movements in unilateral cerebral palsy.
Full text linkMirror movements (MM) influence bimanual performance in children with unilateral cerebral palsy (uCP). Whilst MM are related to brain lesion characteristics and the corticospinal tract (CST) wiring pattern, the combined impact of these neurological factors remains unknown. Forty-nine children with uCP (mean age 10y6mo) performed a repetitive squeezing task to quantify similarity (MM-similarity) and strength (MM-intensity) of the MM activity. We used MRI data to evaluate lesion type (periventricular white matter, N = 30; cortico-subcortical, N = 19), extent of ipsilesional damage, presence of bilateral lesions, and damage to basal ganglia, thalamus and corpus callosum. The CST wiring was assessed with Transcranial Magnetic Stimulation (17 CSTcontralateral, 16 CSTipsilateral, 16 CSTbilateral). Data was analyzed with regression analyses. In the more-affected hand, MM-similarity and intensity were higher with CSTbilateral/ipsilateral. In the less-affected hand, MM-similarity was higher in children with (1) CSTcontra with CSC lesions, (2) CSTbilat/ipsi with PVL lesions and (3) CSTbilat/ipsi with unilateralized lesions. MM-intensity was higher with larger damage to the corpus callosum and unilateral lesions. A complex combination of neurological factors influences MM characteristics, and the mechanisms differ between hands
The assessment of grip strength in preschool-aged children with and without unilateral cerebral palsy
No full textPurpose To investigate reliability and validity of two grip strength devices in children with and without unilateral cerebral palsy (uCP) aged 2-6 years. Method We assessed grip strength in 20 pre-school-aged children with predominantly spastic uCP (mean age 4y0 +/- 1y2m) and 20 age-matched children without uCP (mean age 3y11m +/- 1y3m) using the Martin Vigorimeter and MyoGrip to investigate test-retest reliability (intraclass correlation coefficients; ICC), known-group validity (comparative statistics) and convergent validity (correlation analyses) in a cross-sectional design. Results In both groups, test-retest reliability was excellent for both devices and both hands (ICC 0.91-0.97). Grip strength of the non-preferred hand was lower in children with uCP for both devices (p < 0.001). Grip strength was decreased in the non-preferred compared to the preferred hand in children with uCP for both devices (p < 0.001). In children without uCP, grip strength was lower in the non-preferred compared to the preferred hand only for the MyoGrip (p = 0.02). The relation between both devices for both hands was good to very high (r = 0.62-0.92, p < 0.007). Conclusion Both devices can be implemented in clinical practice to assess grip strength in preschool-aged children with uCP. Only the MyoGrip detected differences between both hands in children without uCP and might be more sensitive.The author(s) reported there is no funding associated with the work featured in this article
Unimanual and bimanual dexterity and its association with sensorimotor impairments in children with unilateral cerebral palsy
No full textChildren with unilateral cerebral palsy (uCP) experience sensorimotor impairments, compromising thedevelopment of manual dexterity which is crucial for performing everyday activities. Recently, the TynesidePegboard Test1 (TPT) was developed, to assess unimanual and bimanual dexterity specifically in childrenwith CP.
This study aimed
– to examine the psychometric properties of the TPT.
– to investigate the impact of sensorimotor impairments on unimanual and bimanual dexterity assessedwith the TP
Sensory function influences unimanual and bimanual dexterity in unilateral cerebral palsy
No full textThe recently developed Tyneside Pegboard Test (TPT) assesses both unimanual and bimanual dexterity in children with unilateral cerebral palsy (uCP). Our aim was to explore the TPT psychometric properties and the impact of sensorimotor impairments on unimanual and bimanual dexterity. Forty-nine children with uCP (mean age 9y8m, SD 1y11m, 30 males, 23 right-sided uCP) performed the unimanual and bimanual TPT providing task duration. For the psychometric properties, known-group validity was evaluated using ANCOVA (between MACS levels) and concurrent and construct validity with Spearman's correlations (r) with known and valid tests (Jebsen-Taylor Hand Function test (JTHFT), Assisting Hand Assessment (AHA), ABILHAND-Kids and Children's Hand Use Experience Questionnaire (CHEQ). The impact of sensorimotor impairments (spasticity, grip force, stereognosis and mirror movements) was investigated using multiple linear regression (α<0.05, R 2). Unimanual and bimanual dexterity differed between MACS levels (known-group validity) (p<0.001). The TPT tasks correlated to the JTHFT (concurrent validity, r=0.86-0.88), the AHA, ABILHAND-Kids and CHEQ (construct validity, r=-0.38-(-0.78)). Stereognosis was the main factor influencing all tasks (p<0.001, R²=37%-50%). Unimanual dexterity was further explained by grip strength (p<0.05, R 2 =8%-9%) and mirror movements in the more-impaired hand (p<0.05, R 2 =4%-8%), while bimanual dexterity was additionally explained by mirror movements in the more-impaired hand (p<0.01, R 2 =10%-16%) and spasticity (p=0.04, R 2 =5%). The TPT is a valid assessment to measure unimanual and bimanual dexterity. This study further highlights that stereognosis is the main determinant for unimanual and bimanual dexterity in children with uCP
Identifying bimanual motor control impairments in children with unilateral cerebrals palsy using the Kinarm End-point robot
No full textIdentifying bimanual motor control impairments in children with unilateral cerebrals palsy using the Kinarm End-point robot
No full textErratum to “The relation between visual functions, functional vision, and bimanual function in children with unilateral cerebral palsy” [Research in Developmental Disabilities 152 (2024) 104792]
No full textThe publisher regrets that the Funding section and Acknowledgements section in this article got incorrectly published. Below is the correctedFunding
The Flemish Research Foundation (FWO project, G0C4919N) provided financial support for this study. This work was additionally supported by the project: “PARENT” funded by the European Union’s Horizon 2020 Project MSCAITN-2020 – Innovative Training Networks Grant No. 956394.
Acknowledgments
The authors would like to express their gratitude to all the participating families and children. Moreover, we thank the master students who assisted with data collection. Lastly, the authors would like to thank Annouschka Laenen, from the Leuven Biostatistics and Statistical Bioinformatics Centre (L-BioStat), for the statistical support. The publisher would like to apologise for any inconvenience caused
Visual, perceptual functions, and functional vision in children with unilateral cerebral palsy compared to children with neurotypical development
No full textAim To investigate visual (perceptual) function and functional vision in children with unilateral cerebral palsy (CP) and children with neurotypical development (NTD). Method Fifty children with unilateral CP (mean age 11 years 11 months, SD 2 years 10 months, range 7-15 years; 27 males; 26 left-sided unilateral CP; Manual Ability Classification System [MACS] levels: I, 27; II, 16; III, 7) and 50 age- and sex-matched children with NTD participated in a cross-sectional study. Visual acuity, stereoacuity, and visual-perceptual functions were measured with standardized clinical tests. Functional vision was assessed in children with unilateral CP with the Flemish cerebral visual impairment questionnaire (FCVIQ). Group differences were investigated with Mann-Whitney U tests, Kruskal-Wallis tests, and the relative effect sizes r, eta(2) respectively. Correlations between visual assessments and the FCVIQ were investigated with Spearman's rank correlations. Results The total group of children with unilateral CP showed reduced visual acuity compared with children with NTD (p = 0.02, r = 0.23). Only children with left-sided unilateral CP scored lower than those with NTD on stereoacuity (p < 0.01, r = 0.36). Children with right/left-sided unilateral CP scored significantly lower than those with NTD on visual-perceptual functions (p = 0.001-0.02), with large effect sizes on visuomotor integration and visual closure (both r = 0.57). Children with unilateral CP classified in MACS level III showed significantly lower scores on visual-perceptual assessments than children classified in MACS level I. Stereoacuity and visual-perceptual functions negatively correlated with the FCVIQ, with the highest association with visual (dis)interest and anxiety-related behaviours. Interpretation Multi-level visual profiling is warranted in the clinical intake of children with unilateral CP to detect visual impairments that further compromise their level of functioning.FUNDING INFORMATION
The Flemish Research Foundation (FWO project, G0C4919N). The project ‘PARENT’ funded by the European Union's Horizon 2020 Project MSCA-ITN-2020 – Innovative Training Networks Grant No. 956394
ACKNOWLEDGEMENTS
We thank all the participating families and children. We also thank the master's students who assisted with data collection
Unimanual and bimanual dexterity and its association with sensorimotor impairments in children with unilateral cerebral palsy
No full textChildren with unilateral cerebral palsy (uCP) experience sensorimotor impairments, compromising thedevelopment of manual dexterity which is crucial for performing everyday activities. Recently, the TynesidePegboard Test1 (TPT) was developed, to assess unimanual and bimanual dexterity specifically in childrenwith CP.
This study aimed
– to examine the psychometric properties of the TPT.
– to investigate the impact of sensorimotor impairments on unimanual and bimanual dexterity assessedwith the TP
Sensory function influences unimanual and bimanual dexterity in unilateral cerebral palsy
No full textThe recently developed Tyneside Pegboard Test (TPT) assesses both unimanual and bimanual dexterity in children with unilateral cerebral palsy (uCP). Our aim was to explore the TPT psychometric properties and the impact of sensorimotor impairments on unimanual and bimanual dexterity. Forty-nine children with uCP (mean age 9y8m, SD 1y11m, 30 males, 23 right-sided uCP) performed the unimanual and bimanual TPT providing task duration. For the psychometric properties, known-group validity was evaluated using ANCOVA (between MACS levels) and concurrent and construct validity with Spearman's correlations (r) with known and valid tests (Jebsen-Taylor Hand Function test (JTHFT), Assisting Hand Assessment (AHA), ABILHAND-Kids and Children's Hand Use Experience Questionnaire (CHEQ). The impact of sensorimotor impairments (spasticity, grip force, stereognosis and mirror movements) was investigated using multiple linear regression (α<0.05, R 2). Unimanual and bimanual dexterity differed between MACS levels (known-group validity) (p<0.001). The TPT tasks correlated to the JTHFT (concurrent validity, r=0.86-0.88), the AHA, ABILHAND-Kids and CHEQ (construct validity, r=-0.38-(-0.78)). Stereognosis was the main factor influencing all tasks (p<0.001, R²=37%-50%). Unimanual dexterity was further explained by grip strength (p<0.05, R 2 =8%-9%) and mirror movements in the more-impaired hand (p<0.05, R 2 =4%-8%), while bimanual dexterity was additionally explained by mirror movements in the more-impaired hand (p<0.01, R 2 =10%-16%) and spasticity (p=0.04, R 2 =5%). The TPT is a valid assessment to measure unimanual and bimanual dexterity. This study further highlights that stereognosis is the main determinant for unimanual and bimanual dexterity in children with uCP
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