62 research outputs found
Mapping São Paulo from Alfredo Moreira Pinto
No full textO presente trabalho tem o objetivo de apresentar os pontos da cidade de São Paulo no ano de 1900 em que o autor Alfredo Moreira Pinto descreve em seu livro, apontando para as modificações da cidade que recebia o propalado “progresso” nos primeiros anos da República. Para o apontamento desses locais descritos será utilizada a plataforma de código aberto Pauliceia 2.0, utilizando as informações descritas pelo autor com a finalidade de aumentar a base de dados da plataforma e apresentar as modificações com relação à espacialização dos espaços visitados por Moreira Pinto na cidade. Ao contrastar os mapas, fica perceptível o que a literatura aponta com relação às áreas centrais mantendo seus polos financeiros e as áreas periféricas recebendo as indústrias. Também foi possível perceber a intenção de novos locais para residências afastados do centro que outrora fora lugar de desejo da elite. A intenção de cartografar a obra de Alfredo Moreira Pinto atinge seu objetivo em documentar a cidade em 1900, com suas modificações em um curto período, além de propiciar um novo material para novas abordagens dentro do recorte temporal.This work aims to present the spots of São Paulo described by the author Alfredo Moreira Pinto in his book "The city of São Paulo in 1900". For pointing out the described places, the open source platform Pauliceia 2.0 will be used, with the purpose of increasing its database and presenting the changes in relation to the spatialization of the city and the urbanization of the period, based on the author's writings. When contrasting the maps, it is noticeable that the literature points to two poles: the central areas, with a focus on the financial area, and the peripheral areas, focused on industries. Also noted is the exploration of new places for residences further away from the center, which was once a region of elite's desire. The intention of mapping the work of Alfredo Moreira Pinto, aims to illustrate the city of 1900, with its modifications in a short period, in addition to providing material for new approaches within the time frame.Não recebi financiament
Copula Parameter Estimation Using Bayesian Inference for Pipe Data Analysis
No full textWater main systems are aging and becoming a growing concern for maintenance. The structural deterioration of water mains is affected by different factors, such as pipe age, pipe material, soil condition, and pipe size, among others. Various methods of modeling have been used to predict the failure of water mains. Since pipe networks are underground and obtaining data on pipe conditions is very costly, statistical modeling has been widely used for pipe condition assessment. An emerging statistical method known as copula modeling is used here for pipe data analysis. The copula method is very useful in cases where marginals belong to different families of distributions. It is also useful for generating a large number of data points when it is difficult to obtain a data set, as is the case for pipe condition assessment, and where data sets have random variables belonging to non-Gaussian family distributions. Different copula families are applied here to model the dependency between the pipe age and repair age of pipes. The paper uses a Bayesian framework to estimate the parameter values in the copula model. This approach offers an additional option for estimating copula parameters for pipe dataThe accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author
Le tourisme en Bulgarie
No full textDans l'article on a présenté les principales directions des recherches scientifiques
dans le domaine de la géographie du tourisme et des autres sciences
s'occupant, en Bulgarie, des problèmes spatiaux du tourisme. On a caractérisé
les centres académiques d'enseignement des cadres, on a aussi présenté les
éditions bulgares consacrées à la problém atique du tourisme. Dans l'article,
l'auteur a mis à profit la littérature accessible du sujet ainsi que ses études
menées en Bulgarie en 1983.Growing inflow of foreign tourists to Bulgaria, whose number exceeded 6 million
persons in 1981, together with development of internal tourist movement intensified
among others by 5-day working week, have generated research interest
shared by many scientific disciplines. The theoretical knowledge about tourist movement and provision of services
for tourists, known as „tourism", is pursued in Bulgaria by representives of
economic and geographical sciences, architects, physicians and others grouped in
two biggest centres i.e. in Sofia and Varna.
The article discusses in greater detail research interests of the geography of
tourism and other sciences dealing with problems of spatial tourist movement in
Bulgaria. There have been distinguished four main directions of those studies. The article is based on the available literature of the subject and on the studies conducted by the author in Bulgaria in 1983
Brassica rapa var. japonica Leaf Extract Mediated Green Synthesis of Crystalline Silver Nanoparticles and Evaluation of Their Stability, Cytotoxicity and Antibacterial Activity
No full textIntranasal Oncolytic Virotherapy with CXCR4-Enhanced Stem Cells Extends Survival in Mouse Model of Glioma
No full textSummaryThe challenges to effective drug delivery to brain tumors are twofold: (1) there is a lack of non-invasive methods of local delivery and (2) the blood-brain barrier limits systemic delivery. Intranasal delivery of therapeutics to the brain overcomes both challenges. In mouse model of malignant glioma, we observed that a small fraction of intranasally delivered neural stem cells (NSCs) can migrate to the brain tumor site. Here, we demonstrate that hypoxic preconditioning or overexpression of CXCR4 significantly enhances the tumor-targeting ability of NSCs, but without altering their phenotype only in genetically modified NSCs. Modified NSCs deliver oncolytic virus to glioma more efficiently and extend survival of experimental animals in the context of radiotherapy. Our findings indicate that intranasal delivery of stem cell-based therapeutics could be optimized for future clinical applications, and allow for safe and repeated administration of biological therapies to brain tumors and other CNS disorders
Recent Progress and Approaches on Carbon-Free Energy from Water Splitting
No full textSunlight is the most abundant renewable energy resource, providing the earth with enough power that is capable of taking care of all of humanity’s desires—a hundred times over. However, as it is at times diffuse and intermittent, it raises issues concerning how best to reap this energy and store it for times when the Sun is not shining. With increasing population in the world and modern economic development, there will be an additional increase in energy demand. Devices that use daylight to separate water into individual chemical elements may well be the answer to this issue, as water splitting produces an ideal fuel. If such devices that generate fuel were to become widely adopted, they must be low in cost, both for supplying and operation. Therefore, it is essential to research for cheap technologies for water ripping. This review summarizes the progress made toward such development, the open challenges existing, and the approaches undertaken to generate carbon-free energy through water splitting.[Figure not available: see fulltext.]. © 2019, © 2019, The Author(s).Different approaches for efficient carbon-free energy from water splitting are summarized.Step-wise evolution of water splitting research is highlighted with current progress.It describes the open challenges of charge transport properties and future research direction. © 2019, The Author(s)
A systematic review on silver nanoparticles-induced cytotoxicity: Physicochemical properties and perspectives
No full text
Stability Enhancement of Silver Nanoparticles Through Surface Encapsulation via a Facile Green Synthesis Approach and Toxicity Reduction
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