44 research outputs found
Etiology and management of primary amenorrhoea: A study of 102 cases at tertiary centre
No full textObjective: To determine the prevalence of etiologic causes of primary amenorrhea in Indian population.
Materials and methods: A retrospective study was performed using 102 complete medical records of women with primary amenorrhea who attended the Gynaecologic Endocrinology Clinic, Department of Obstetrics and Gynaecology, AIIMS, New Delhi from September 2012 to September 2015. Cases were analysed according to clinical profile, development of secondary sexual characteristics, physical examination, pelvic and rectal examination, X-ray of chest and lumbo-sacral spine, hormone profile, pelvic USG, MRI, and cytogenetic study including karyotype.
Results: The three most common causes of primary amenorrhea were Mullerian anomalies (47%), gonadal dysgenesis (20.5%), and hypogonadotropic hypogonadism (14.7%) in the present study. There were 3 cases of Turner syndrome (45,XO), 5 cases of Swyer's syndrome (46,XY) and 2 cases of Androgen insensitivity syndrome (46,XY). One case had pituitary macroadenoma and eight cases (7.8%) were of genital tuberculosis.
Conclusions: The present study has currently been the largest case series of primary amenorrhea from North India. Mullerian anomaly is the most prevalent etiological factor leading to amenorrhoea followed by gonadal dysgenesis in our study. Racial, genetic and environmental factors could play role in the cause of primary amenorrhea
Laparoscopic Management of Leiomyoma Arising from Müllerian Remnant in Mayer–Rokitansky–Küster–Hauser Syndrome
No full textFollicular flushing versus direct aspiration at oocyte retrieval in poor responders undergoing in vitro fertilization: A randomized controlled trial
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Successful management of caesarean scar live ectopic pregnancies with local KCL and systemic methotrexate
No full textSuccessful reproductive outcome after laparoscopic Strassmann’s metroplasty
No full textMullerian anomalies cause a significant impact on the reproductive outcomes. A bicornuate uterus is a type of lateral fusion defect, which constitutes 26% of all uterine anomalies. Strassmann’s metroplasty is a unification procedure performed to correct the two smaller uterine cavities into a more spacious single cavity. Improved reproductive performance was reported after unification metroplasty. Laparoscopic route can be adopted for this procedure with all the advantages of minimally invasive surgery. Here, we report a success story of a woman who suffered with six miscarriages and secondary infertility who underwent laparoscopic Strassmann’s metroplasty in a tertiary care center and later delivered a baby by caesarean section
Comparison of obstetric outcomes of pregnancies after donor oocyte IVF: Three-arm age-matched retrospective cohort study
No full textBackground: Oocyte donation has become widely used as a treatment option for infertile couples. The few available studies report conflicting evidence about the risk of hypertensive disorders in donor oocyte pregnancies after adjusting for maternal age and it is unclear whether pregnancy complications and obstetric risks are due to oocyte donation or to confounding factors such as maternal age. The aim of the present study was to evaluate and compare obstetric complications between women who conceived after oocyte donation and age-matched control women with spontaneous conception and self oocyte IVF conception.Methods : The present study comprised of women aged 20-45 years conceived from oocyte donation (n=104) between 1/12/2010 to 15/10/2017. Two age-matched control groups—Self oocyte IVF (n=150) and the other containing women who conceived spontaneously (n=312) were used for comparison of obstetric and perinatal outcomes.Results: Mean maternal age was statistically significantly higher in the Donor oocyte IVF group as compared to self oocyte ivf and spontaneous conception group. Miscarriage, first trimester bleeding, pregnancy induced hypertension and gestational diabetes mellitus was significantly higher in Donor oocyte IVF group as compared to self-oocyte and spontaneous conception group (p=0.001). Using multiple logistic regression analysis age class adjusted PIH and GDM incidence was significantly higher in donor oocyte group as compared to spontaneous conception (P=0.010).There was significant variation in perinatal outcomes between the three groups.Conclusion: Oocyte donation should be treated as an independent risk factor for miscarriage, first trimester bleeding, hypertensive disorder and gestational diabetes mellitus in pregnancy.</jats:p
