86,994 research outputs found
ASO Author Reflections: Is Breast-Conserving Surgery a Safe Treatment Option for High-Risk Breast Cancer?
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Ruins of the past: the use and perception of abandoned structures in the Maya lowlands
No full textTravix W. Stanton and Aline Magnoni, editors.Includes bibliographical references and index.From the Formative to the present, Maya peoples have continuously built, altered, abandoned, and re-used structures, imbuing them with new meanings at each transformation. Ruins of the Past is the first volume to focus on how previously built structures in the Maya Lowlands were used and perceived by later peoples, exploring the topic through concepts of landscape, place, and memory.--Book jacket.Foreword / Wendy Ashmore -- Places of remembrance: the use and perception of abandoned structures in the Maya lowlands / Travis W. Stanton and Aline Magnoni -- Forgotten structures, haunted houses, and occupied hearts: ancient perspectives and contemporary interpretations of abandoned sites and buildings in the Mirador Basin, Guatemala / Richard D. Hansen, Wayne K. Howell, and Stanley P. Guenter -- The transformation of abandoned architecture at Piedras Negras / Mark B. Child and Charles W. Golden -- Structure abandonment and landscape transformation: examples from the Three Rivers region / Lauren A. Sullivan [and others] -- Manipulating memory in the wake of dynastic decline at El Perú-Waka': termination deposits at abandoned structure M13-1 / Olivia C. Navarro Farr, David A. Freidel, and Ana Lucía Arroyave Prera -- Establishing and reusing sacred place: a diachronic perspective from Blackman Eddy, Belize / M. Kathryn Brown and James F. Garber -- Anatomy of a post-collapse society: identity and interaction in early postclassic Copán / T. Kam Manahan -- Landscape transformations and changing perceptions at Chunchucmil, Yucatán / Aline Magnoni, Scott R. Hutson, and Travis W. Stanton -- Edzná: a lived place through time / Antonio Benavides C. -- Memories, meanings, and historical awareness: post-abandonment behaviors among the lowland Maya / Marcello A. Canuto and Anthony P. Andrews -- Afterword / Denise Fay Brown
Digitalização e Sociedade: ideias e assertivas sobre Economia Política da Comunicação: CARVALHO, Juliano M.; MAGNONI, A. F.; PASSOS, Mateus Yuri R. S. (Org). Economia Política da Comunicação:digitalização e sociedade. São Paulo: Cultura Acadêmica, 2013
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CARVALHO, Juliano M.; MAGNONI, A. F.; PASSOS, Mateus Yuri R. S. (Org). Economia Política da Comunicação:digitalização e sociedade. São Paulo: Cultura Acadêmica, 2013
Indexaçã
Progress in breast cancer surgical management
No full textEvolution in breast cancer surgery has been significant over these four decades. Many scientific changes have been reached, impacting daily clinical practise, thanks to scientific research and surgeons' efforts, always tended to warrant oncological radicality as well improve women quality of life and cosmesis. Achievements in imaging, in breast cancer molecular signature characterization and patients' genomic profile are progressively refining a sophisticated personalization of breast cancer prevention and treatment. Progress in surgery involves both primary breast site surgery and surgical axillary staging, revealing a strong propensity for a limited surgical approach and technical precision. Multimodal management and individualization are the axioms on which current research on breast cancer prevention and treatment is progressing
Sentinel node biopsy in conservative surgery for breast cancer: a changing role in clinical practice
No full textRecent studies have demonstrated that the extent of surgical treatment in both breast and axilla can be minimized through a multimodal and personalized management, based on assessment of breast cancer (BC) molecular subtypes, genetics and on the prevailing relevance of systemic therapies. Axillary lymph-nodes dissection (ALND) represents the older surgical modality for appropriate staging and for adjuvant systemic and radiation therapies planning. Thanks to findings from extensive and crucial clinical trials, sentinel lymph node biopsy (SLNB) replaced this approach, obviating the need for ALND in node-negative disease patients, both in mastectomy and conservative surgery, and becoming a crucial turning point in BC managing. Furthermore, recent clinical trials have established that ALND can be avoided in those patients with low axillary disease burden in the sentinel nodes who are undergoing breast-conserving surgery (BCS) with radiotherapy. Several studies also proved that neoadjuvant chemotherapy (NAC) increases the BCS rates, as well reducing the extent of axillary surgery. The potential oncological safety of axillary observation choice in early BC patients undergoing BCS, in the recent perspective of the prevailing value of BC biology, is also under scientific evaluation. This study explores the current role of SLNB in BC patients eligible for BCS, providing a view into future directions in BC care
A polypurine sequence that acts as a 5' mRNA stabilizer in Mycobacterium tuberulosis and Mycobacterium smegmatis
No full textDNA replication in phage P4: Characterization of replicon II
No full textThe genetic element P4 propagates in its host Escherichia coli both as a satellite phage and as a plasmid. Two partially overlapping replicons coexist, namely replicon I and replicon II. The former is composed of two sites, ori1 and crr, and depends on P4 (alpha) gene product for replication. The P4 (alpha) protein has primase and helicase activities, and binds specifically to both ori1 and crr. Replicon II is composed of two sites, ori2 and crr, and its replication also depends on P4 (alpha) primase and helicase activities. In replicon II, the (alpha) protein binds only crr. Here we show that for replicon II the relative orientation of ori2 and crr is essential for replication to occur. Furthermore we delimit ori2 to a 22 bp region (6234-6255), internal to the (alpha) gene, sufficient for replicon II replication. We mutagenized this region and identified two mutants, which carry one and two base substitutions, respectively, that prevent replicon II replication. In electrophoretic mobility shift experiments of ori2, ori1, and crr DNA fragments with E. coli extracts, ori2 was not shifted, whereas both ori1 and crr were specifically bound, suggesting that other host protein(s), beside P4 (alpha), are able to bind to these cis essential regions. Apparently, no binding to ori2 could be identified, thus suggesting that neither (alpha) nor other bacterial proteins specifically bind to this region
PAC learning of probability distributions over a discrete domain
No full textWe investigate learning of classes of distributions over a discrete domain in a PAC context. We introduce two paradigms of PAC learning, namely absolute PAC learning, which is independent of the representation of the class of hypotheses, and PAC learning wrt the indexes, which heavily depends on such representations. We characterize non-computable learnability in both contexts. Then we investigate efficient learning strategies which are simulated by a polynomial-time Turing machine. One strategy is the frequentist one. According to this strategy, the learner conjectures a hypothesis which is as close as possible to the distribution given by the frequency relative to the examples. We characterize the classes of distributions which are absolutely PAC learnable by means of this strategy, and we relate frequentist learning wrt the indexes to the NP = RP problem. Finally, we present another strategy for learning wrt the indexes, namely learning by tests
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