2,193 research outputs found
Progress in breast cancer surgical management
No full textEvolution in breast cancer surgery has been significant over these four decades. Many scientific changes have been reached, impacting daily clinical practise, thanks to scientific research and surgeons' efforts, always tended to warrant oncological radicality as well improve women quality of life and cosmesis. Achievements in imaging, in breast cancer molecular signature characterization and patients' genomic profile are progressively refining a sophisticated personalization of breast cancer prevention and treatment. Progress in surgery involves both primary breast site surgery and surgical axillary staging, revealing a strong propensity for a limited surgical approach and technical precision. Multimodal management and individualization are the axioms on which current research on breast cancer prevention and treatment is progressing
Sentinel node biopsy in conservative surgery for breast cancer: a changing role in clinical practice
No full textRecent studies have demonstrated that the extent of surgical treatment in both breast and axilla can be minimized through a multimodal and personalized management, based on assessment of breast cancer (BC) molecular subtypes, genetics and on the prevailing relevance of systemic therapies. Axillary lymph-nodes dissection (ALND) represents the older surgical modality for appropriate staging and for adjuvant systemic and radiation therapies planning. Thanks to findings from extensive and crucial clinical trials, sentinel lymph node biopsy (SLNB) replaced this approach, obviating the need for ALND in node-negative disease patients, both in mastectomy and conservative surgery, and becoming a crucial turning point in BC managing. Furthermore, recent clinical trials have established that ALND can be avoided in those patients with low axillary disease burden in the sentinel nodes who are undergoing breast-conserving surgery (BCS) with radiotherapy. Several studies also proved that neoadjuvant chemotherapy (NAC) increases the BCS rates, as well reducing the extent of axillary surgery. The potential oncological safety of axillary observation choice in early BC patients undergoing BCS, in the recent perspective of the prevailing value of BC biology, is also under scientific evaluation. This study explores the current role of SLNB in BC patients eligible for BCS, providing a view into future directions in BC care
IL CAPITOLO DELLA CATTEDRALE DI BERGAMO NEL XIV SECOLO
No full textThe dissertation investigates the Cathedral chapter of Bergamo in fourteenth century and focuses on the relationships among bishops and chapter members, seeking to reconstitute the social composition of this group, but also the chapter itself as an institution. I have studied the statutes of the chapter, the dignities and minor officials, the residentiary system, prebends and their value, daily life in church. A particular attention is also reserved to sources and their authors, the notaries, a group that lies between laical society and canons
"The love that made hell, paradise." Ouida re-writing the Paolo and Francesca theme in Held in Bondage
No full textThe bestselling Victorian author Ouida reveals in her novels, and, in particular, Held in Bondage, an extraordinary knowledge od Dante, by using characters and themes from the Commedia. The Paolo and Francesca theme actually constitutes part of the plot of the novel and is to be found in many of her other works, short stories and non-fiction writing
HERStory Makers 2023: Francesca Fotheringham
No full textFrancesca Fotheringham is a postdoctoral research associate at the University of Edinburgh studying educational psychology with a focus on neurodiversity. She took part in HERStory Makers 2023.What is HERStory Makers?HERStory Makers is a social media competition for female-identifying early career researchers to share their research, their career journeys, and to inspire the next generation. Winners are selected by public vote. HERStory Makers is also part of EXPLORATHON, Scotland's contribution to European Researchers' Night.In 2022-23, EXPLORATHON Francescasupported by the Engineering & Physical Sciences Research Council [grant number EP/X020762/1].Author contributions to contentFrancesca conceived, planned, and recorded the video content. Kirsty Ross edited the video content to insert HERStory Maker credits, added subtitles, and reduce video length to below Twitter/X limit of 2 mins and 20 secs.</p
The katG mRNA of Mycobacterium tuberculosis and Mycobacterium smegmatis is processed at its 5 ' end and is stabilized by both a polypurine sequence and translation initiation
No full textBackground: In Mycobacterium tuberculosis and in Mycobacterium smegmatis the furA-katG loci, encoding the FurA regulatory protein and the KatG catalase-peroxidase, are highly conserved. In M. tuberculosis furA-katG constitute a single operon, whereas in M. smegmatis a single mRNA covering both genes could not be found. In both species, specific 5' ends have been identified: the first one, located upstream of the furA gene, corresponds to transcription initiation from the furA promoter; the second one is the katG mRNA 5' end, located in the terminal part of furA.UPCO
Medicina illuminata. La Biblioteca Lancisiana di Roma
No full textL'articolo presenta i codici miniati della Biblioteca Lancisiana di Roma. La prima parte, del coautore, è dedicata alla Biblioteca. La seconda parte, di F. Manzari, tratta dei manoscritti miniati, costituiti da due codici con le opere di Avicenna e dal Liber fraternitatis della Confraternita dell'Ospedale di Santo Spirito in Sassia a Roma.The article introduces the illuminated manuscripts of the Biblioteca Lancisiana in Rome. The first part of the article, by the co-author, is dedicated to the Library. The second part, by Francesca Manzari, illustrates the manuscipts; these are two manuscripts with the works of Avicenna and the Liber fraternitatis of the Confraternity of the Hospital of Santo Spirito in Sassia in Rome
A DH-Leavened Musicological Toolbox
No full textGraduate-level training in music research methodologies tends to ignore digital humanities work and overlook the use of digital tools created in support of new forms of reading. Training instead focuses on source material in the student’s area of interest. This material includes secondary and primary (archival) resources, as well as information resources, such as: monuments of music and critical editions; indexes; bibliographies and thematic catalogs; dictionaries and encyclopedias; digital libraries of scores or editions; and databases of period-specific newspapers or journals. Graduate students taking research methods courses already have a toolbox built from their experiences as musicians and students of music, including the ability to read and interpret music notation, to understand theoretical and analytical concepts in music, as well as a command of music history, including the canon of musical works.
Digital humanities has become a major area of academic endeavor at the “interface of technological development, epistemological change and methodological concerns." An important characteristic of digital humanities research has been its interdisciplinarity. We argue that graduate training in musicology needs to include coverage of methodologies applied by digital humanists in support of new forms of reading, not only to broaden the canon of research topics in musicology, but also to build common ground with researchers of other disciplines. We propose that librarians are well positioned to provide this expertise and training
Un eritema anulare centrifugo ricorrente da molti anni in estate
No full textL’eritema anulare centrifugo ricorrente annualmente è una peculiare variante clinica di eritema anulare centrifugo superficiale, clinicamente ed istologicamente indistinguibile da questo, ma caratterizzato da una ricorrenza annuale e stagionale. Presentiamo il caso di una donna di 46 anni con un’importante sintomatologia pruriginosa. All’esame obiettivo si rilevava la presenza di chiazze eritematose con risoluzione centrale multiple e confluenti agli arti superiori ed inferiori. Il cavo orale, faccia, tronco, mani e piedi erano risparmiati dalle lesioni. La paziente non assumeva farmaci, non era affetta da patologie sistemiche e riferiva che tali manifestazioni si presentavano ogni anno, da 8 anni a questa parte, nel periodo estivo e regredivano spontaneamente in autunno. La diagnosi differenziale dell’eritema anulare centrifugo comprende principalmente il granuloma anulare, micosi fungoide, pitiriasi rosea, tinea corporis, sarcoidosi, orticaria e lebbra. Clinicamente le manifestazioni cutanee deponevano per un quadro di eritema anulare centrifugo. Veniva eseguita una biopsia cutanea il cui quadro istologico, caratterizzato da un infiltrato infiammatorio perivascolare linfoistiocitario nel derma papillare e medio, confermava la diagnosi di eritema anulare centrifugo. Mediante l’esecuzione di una completa serie di esami di laboratorio e strumentali veniva esclusa la presenza di una patologia sottostante. Veniva impostata una terapia sistemica steroidea con risoluzione del quadro cutaneo
Negative Pigment Network Identifies a Peculiar Melanoma Subtype and Represents a Clue to Melanoma Diagnosis: A Dermoscopic Study of 401 Melanomas
No full textThe dermoscopic descriptor "negative pigment network" (NPN) has been reported in several types of melanocytic and non-melanocytic lesions, although it has a higher frequency of association with melanoma and Spitz naevus. In a study of 401 consecutive melanomas, excluding facial, acral and mucosal locations, the frequency and variability of NPN were investigated, and the results of NPN correlated with clinical and histopathological data. NPN of any extension was found in 27% of melanomas, most frequently invasive and arising from a naevus on the trunk of young subjects. Seven percent of melanomas in the study population showed presence of NPN in more than half of the lesion area; most of these did not show typical dermoscopic melanoma features. The authors propose a new melanoma subtype, in which extensive NPN should be considered as a diagnostic indicator
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