58,215 research outputs found
Diffusive author(s), cohesive author: Analysis of S/N (1994)
No full textThis study indicates the ways in which various aspects of the author(s) are brought forth in Dumb type’s performance art, the S/N production. Previous research has suggested a non-hierarchical organization of Dumb type and the absence of a “privileged author” in Dumb type’s collaborative work, S/N. However, the results that I have investigated from member’s interviews on the creative process of S/N along with my analysis of the recorded images of S/N, indicate a different aspect of the author(s). First, S/N was created through, so to speak, the collective ideas of the members of Dumb type. Further, S/N has at least nine quotations from previous performances, installations, and printed writings, besides the work-in-progress technique. Explicating one of the “author functions” as given by Michel Foucault, each text has plural subjects of the author. However, it has been revealed from members’ interviews that Teiji Furuhashi had a decision-making role in selecting the members’ ideas within the performance. Since then, S/N has had plural subjects of creation; however, Furuhashi is one of the subjects of creation along with the “privileged author.” S/N has plural authors (diffusive authors) yet at the same time, it has a “privileged author,” Teiji Furuhashi (cohesive author)
Rappresentanza e pariteticità
No full textIl contributo commenta la Sezione VII del Capo III del Titolo I del d.lgs. n. 81/2008 che ricomprende le norme sulla rappresentanza collettiva dei lavorator
43rd NATIONAL CONGRESS OF THE ITALIAN SOCIETY OF MICROBIOLOGY
No full textIntroduction: Capsaicin (8-methyl-N-vanillyl-
6-nonenamide) is the active component responsible
for the fruit pungency of Capsicum plants,
cultivated for food and also for medicinal uses since
ancient times. Besides its multiple pharmacological
and physiological properties (pain relief, cancer
prevention, weight reduction, cardiovascular, and
gastrointestinal benefits), capsaicin has recently
received attention because of its antimicrobial activity
and anti-virulence properties. The aim of the
present study was to investigate the effects of capsaicin
on Streptococcus pyogenes, the most common
cause of acute bacterial pharyngotonsillitis.
Materials and Methods: The erythromycin-resistant
[erm(B)/cMLS], high cell-invasive, and strong
biofilm producer S. pyogenes pharyngeal isolate
SP1070 was used throughout the study. Capsaicin
was purchased from Sigma-Aldrich and stored (10
mg/mL stock solution) in absolute ethanol at -20°C.
The MIC and MBC were determined according to
the CLSI guidelines. Survival in presence of capsaicin
was studied by the live/dead assay. Biofilm
formation was tested by a microtiter assay and
quantified by measuring the absorbance at 690 nm.
Cell experiments were performed using the human
alveolar carcinoma A549 cell line.
Results: The MIC and the MBC of capsaicin were
both 128 μg/mL. In the live/dead assay, several red
cells were detected as early as 15 min after incubation
with capsaicin at MIC; all cells were red after
60 min of incubation. At capsaicin sub-MICs (1/2– 1/16 × MIC), a significant increase in biofilm production
and in the number of streptococci adherent
to A549 cells was observed; whereas a strong reduction
in the number of intracellular bacteria was
detected.
Discussion and Conclusions: Our findings reveal
that capsaicin has a dual effect on S. pyogenes.
High-level capsaicin exerts a bactericidal effect,
probably due to the disruption of the cell membrane,
this result being in agreement with previous
studies on Gram-positive and Gram-negative
pathogens; while sub-lethal capsaicin modifies
virulence properties in vitro, such as the ability to
form biofilm and to adhere/invade epithelial cells.
Capsaicin-induced effects on biofilm formation
seem to be similar to those observed for a variety of
antibiotics that at sub-lethal concentrations can act
as agonists of bacterial biofilm production in vitro.
Overall, capsaicin-induced effects on S. pyogenes
deserve further studies
Percezione e trattamento del dolore oncologico: esperienza presso un day hospital toscano
No full textINTRODUZIONE: La cura del dolore fisico è una delle principali ragioni di esistere della Medicina. La ricerca scientifica ed ancor più la presa in carico “organizzativa” di questo primario bisogno sono, da sempre, ostacolati dalla difficoltà della sua misurazione, ad oggi inevitabilmente affidata alla psicometria. La nostra legislazione, da qualche tempo, cerca di modificare il tradizionale, insufficiente, approccio clinico al problema.
OBIETTIVO: Quantificare la comparsa di dolore in pazienti oncologici ed analizzare le modalità del suo trattamento adottate a livello locale.
MATERIALI E METODI: Dal 1 Giugno al 30 Settembre 2010 tutti i ricoveri oncologici avvenuti presso il Day Hospital dell’Ospedale “S.Giovanni di Dio” di Firenze sono stati registrati mediante scheda ad hoc, riportante, per ciascuno, diagnosi principale, stadio della malattia, presenza o meno di metastasi, patologie associate, terapie effettuate in passato ed in corso, trattamento del dolore, cronologia di quest’ultimo, effetti della terapia. La valutazione del dolore è avvenuta mediante Visual Analogue Scale e Brief Pain Scale.
RISULTATI: Sono stati esaminati 203 soggetti (106 femmine e 87 maschi), selezionati su base volontaria, di età 30-80 anni (media 66,8 – d.s. +/- 11). I pazienti in fase avanzata e/o metastatica hanno ricevuto nel 14% dei casi un trattamento di supporto, nell’86% chemio-radioterapia. Sedi di patologia primitiva erano: colon (44%), mammella (22%), prostata (10%). I pazienti che hanno fatto registrare più sindromi dolorose sono stati quelli con malattia localizzata a livello di ossa, peritoneo e fegato. Per quanto concerne l’intensità, secondo la Brief Pain Scale, tra i pazienti con dolore nocicettivo somatico profondo, il più importante, la maggior parte lo ha presentato di tipo continuo (22), seguito dall’intermittente (16), dall’incidente (2) ed infine dal breakthrough pain (2). I pazienti sono stati trattati nel 23% dei casi con oppioidi maggiori, nel 23% con oppioidi minori, nel 18% con FANS e nel 5% con adiuvanti; nel 31% dei casi il dolore non risulta essere stato trattato.
CONCLUSIONI: Lo studio sembra evidenziare come, sebbene il dolore sia ormai adeguatamente rilevato, non sia ancora uniforme la sua presa in carico terapeutica. La spiegazione del mancato trattamento, registrato nel 31% della nostra casistica, è forse da ricercarsi in ambito culturale, più che scientifico: l’uso di oppioidi è spesso stato identificato dalla nostra “cultura” in senso negativo ed irreversibile. Ciò nuoce alla qualità della vita del paziente terminale, in particolare neoplastico
Lattice Boltzmann Simulations of Particle Motion in a Turbulent Channel Flow
No full textParticle resolved direct numerical simulations (PR-DNS) of particle-laden turbulent flow in a channel are carried out to understand the effect of particle Stokes number (St) on their motion. The study focuses on particles which are larger than the Kolmogorov scale. The forces that impact this motion are factored into the discussion. The lattice Boltzmann method (LBM) is employed for the simulations. The scheme employed is able to resolve the surface of the particle and a method is adopted to account for the exchange of momentum between the particles and fluid as the particles move on fixed lattices. The simulations show that particles with relatively lower St move preferentially toward the wall while those with higher St exhibit a relatively uniform concentration
Fully-resolved direct numerical simulations of particle motion in a turbulent channel flow with the lattice-Boltzmann method
No full textParticle-resolved direct numerical simulations (PR-DNS) of particle-laden turbulent flow in a channel are carried out to understand the effect of particle Stokes number ( St ) on their motion. The study focuses on particles which are larger than the Kolmogorov scale. The forces that impact this motion are factored into the discussion. The lattice-Boltzmann method (LBM) is employed for the simulations. The scheme em- ployed is able to resolve the surface of the particle and a method is adopted to account for the exchange of momentum between the particles and fluid as the particles move on fixed lattices. The simulations show that particles with relatively lower St move preferentially toward the wall while those with higher St exhibit a relatively uniform concentration
Magi is associated with lipid subdomains and alters PIP3 levels.
No full text(A-I) Cherry-tagged Magi (red) was expressed using apterous-GAL4 and accumulations within the basolateral region. (A-C) Magi::Cherry accumulations were positive for the ER marker Calnexin (green), arrows. (D-F) PIP3 (PH::GFP; green) was co-localized in the large accumulations (arrows) with Magi::Cherry. (G-I) Magi::Cherry accumulations were positive for Cholera toxin B (CTB, green)(arrows). (J-L) Endogenous Magi (red) colocalized with cholera toxin B (CTB, green) in wildtype discs at the plasma membrane. (M-S) Cherry-tagged Magi was overexpressed using apterous-GAL4 (ap>Magi::Cherry). The apterous boundary is indicated with a white line. (M-P) Wing imaginal discs overexpressing Magi::Cherry (red) with a PIP3 indicator (PH::GFP, green) under the control of the tubulin promoter. High levels of Magi resulted in an increase in of PIP3 at the plasma membrane. *** p<0.001; n = 5 discs. Error bars indicate SEM. (Q-S) Side projections showing the increase in PIP3 is within the apical domain (arrow) and within the large Magi accumulations (arrowhead). (T-Y) PTEN was expressed using apterous-GAL4 with Magi::Cherry (T-V) or without (W-Y). (T-V) Baz (green) was still displaced from the membrane when PTEN (blue) and Magi::Cherry (red) were coexpressed. (W-Y) Expression of PTEN alone had no effect on Magi recruitment to the membrane (arrowhead). Panels (A-L) were digitally magnified 200%. Scale bars indicate 5μm</p
Documentazione
No full textIl contributo si concentra sul tema della semplificazione e delle regole sulla documentazione tecnico-amministrativa e le statistiche in materia di salute e sicurezza sul lavor
Gestione delle emergenze
No full textIl contributo affronta il tema della gestione delle emergenze, disciplinato dal Testo Unico in materia di salute e sicurezza nei luoghi di lavoro, che prevede le misure di prevenzione e protezione che i datori di lavoro sono tenuti ad attuare in termini di primo soccorso, lotta antincendio e in caso di pericolo grave e immediat
Promote equal access to COVID19 vaccination: strategies of the Local Authority Toscana SudEst, Italy
No full textThe creation of dedicated interventions guaranteed to achieve high vaccination coverage in all nationalitie
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