1,721,156 research outputs found
Debate: Tissue Engineered Valves Will Dominate in the Future
No full textSir Magdi Yacoub of the Imperial College London in the UK and Patrick Serruys of the Thoraxcenter Erasmus University in Rotterdam, Netherlands, discuss the use of tissue-engineered valves versus endogenous tissue restoration. This debate was presented at the Heart Valve Society (HVS) Annual Meeting 2019 in Sitges, Spain, and is presented here with permission from HVS. For more information on upcoming events, please visit the HVS website
Editors’ page
No full textThis issue of the journal introduces a new regular feature entitled “Lessons from the trials”, presented by experts in the fields, which includes a description as well as a critique of the trial, and outlines how it could influence practice and future directions. Clinical trials are an essential part of evidence-based cardiovascular practice. An increasing number of trials are being published and talked about in international meetings, such as the latest conference of the European Society of Cardiology. Another addition to the journal is the inclusion of reports from recent specialized meetings addressing exciting topics of wide-ranging interest. In this issue Drs Franco Cecchi and Iacopo Olivotto summarize the presentations from the Florence Symposium on Advances on Cardiomyopathies, which addressed clinical, basic science and translational topics with many new findings We invite submissions in these new sections as well as in the core subjects of the journal - and welcome any comments or suggestions regarding the contents of the journal and its relevance to our readership
Report on the 2nd Florence International Symposium on Advances in Cardiomyopathies: 9th meeting of the European Myocardial and Pericardial Diseases WG of the ESC
No full textA bridge between clinical and basic science aiming at cross fertilization, with leading experts presenting alongside junior investigators, is the key feature of the “2nd Florence International Symposium on Advances in Cardiomyopathies” , 9th Meeting of the Myocardial and Pericardial Diseases Working Group of the European Society of Cardiology, which was held in Florence, Italy on 26--28th September 2012. Patients with cardiomyopathies, with an estimated 3 per thousand prevalence in the general population, constitute an increasingly large proportion of patients seen by most cardiologists. This class of diseases, which are mostly genetically determined with different transmission modalities, can cause important and often unsolved management problems, despite rapid advances in the field. On the other hand, few other areas of cardiology have seen such an impressive contribution from basic science and translational research to the understanding of their pathophysiology and clinical management. The course was designed to constantly promote close interaction between basic science and clinical practice and highlight the top scientific and translational discoveries in this field in 10 scientific sessions. It was preceded by two mini--courses, which included the basic concepts of cardiomyocyte mechanical and electrophysiological properties and mechanisms, how--to sessions for clinical diagnosis and management and illustrative case study presentations of different cardiomyopathies
Endo-aneurysmorrhaphy of a giant aneurysm of the subclavian vein
Full text linkVenous aneurysms are relatively rare anomalies which can affect different parts of the vascular system. Diagnosis and management of this condition could pose important problems. We here report a giant false aneurysm of the subclavian vein with emphasis on the thought process that determined the management strategy
The inaugural visit of Chain of Hope representatives to Kampala: The beginning of a fruitful collaboration
Full text linkRole of hypoxia inducible factor HIF-1α in heart valves
Full text linkThe 2016 Albert Lasker Basic Medical Research Award and subsequently the 2019 Nobel Prize in Physiology or Medicine were awarded to William Kaelin, Jr., Sir Peter Ratcliffe, and Gregg Semenza for their work on how cells sense and adapt to hypoxic conditions. Their work showed that the changes in gene expression, cell metabolism, and tissue remodelling that occur in response to low oxygen concentrations are orchestrated by the transcription factor, hypoxia inducible factor-1α (HIF-1α). While the effects mediated by HIF-1α have been widely studied, its role in heart valves has only recently been investigated. These studies have shown that HIF-1α expression is evident in mechanisms that regulate the structure and function of heart valves. These include embryonic development, the regulation of the extracellular matrix, angiogenesis and the initiation of the calcification process. This review provides a background on the role and function of HIF-1α in response to hypoxia and a discussion of the available evidence of its involvement in the regulation of heart valves in health and disease
Supplemental Material, suppl_tables - Shock Index in Patients Presenting With Acute Heart Failure: A Multicenter Multinational Observational Study
No full textSupplemental Material, suppl_tables for Shock Index in Patients Presenting With Acute Heart Failure: A Multicenter Multinational Observational Study by Ayman El-Menyar, Kadhim Sulaiman, Wael Almahmeed, Ahmed Al-Motarreb, Nidal Asaad, Khalid F. AlHabib, Alawi A. Alsheikh-Ali, Mohammed Al-Jarallah, Rajvir Singh, Magdi Yacoub and Jassim Al Suwaidi in Angiology</p
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