1,721,198 research outputs found
Trasferimenti fitoplanctonici attraverso lo stretto di Messina in relazione alle condizioni idrologiche
No full textConceptualising the Coronavirus Pandemic: A Corpus Linguistic Study of Metaphors in Italian and British Coronavirus Press Discourse
No full textDuration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease
No full textBackground and Aims: The relationship between celiac disease and many autoimmune disorders has been explained by the sharing of a common genetic factor. In a multicenter national study, we examined the relationship between the prevalence of autoimmune disorders in celiac disease and the duration of exposure to gluten. Methods: Over a 6-month period, 909 patients with celiac disease (group A; mean age, 16.1 ± 3.8 years; grouped according to age at diagnosis into three subgroups [group A1, 10 years]), 1268 healthy controls (group B; mean age, 20.8 ± 4.5 years), and 163 patients with Crohn's disease (group C; mean age, 28.8 ± 10 years) were evaluated for the presence of autoimmune disorders. Results: Prevalence of autoimmune disorders in group A was significantly higher than in group B (14% vs. 2.8%; P < 0.000001) but not higher than in group C (12.9%). Prevalence of autoimmune disorders in celiac disease increased with increasing age at diagnosis: 5.1% in group A1, 17% in group A2, and 23.6% in group A3 (P = 0.000001). In group A3, the prevalence of autoimmune disorders was significantly higher than in group C. In a logistic regression model, age at diagnosis was the only significant predictor variable of the odds of developing an autoimmune disorder (r = 0.3; P < 0.000001). Conclusions: Our data show for the first time that the prevalence of autoimmune disorders in celiac disease is related to the duration of exposure to gluten
Dinamica degli accumuli di detrito organico nello stagno salmastro di Acquatina (Lecce).
No full textDuration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease. SIGEP Study Group for Autoimmune Disorders in Celiac Disease.
No full textGASTROENTERO
Radiation hardness by design techniques for 1 grad TID rad-hard systems in 65 nm standard CMOS technologies
No full textThe paper shows the radiation effects on 65 nm standard CMOS technology and RHBD (Radiation Hardening By Design) techniques developed to reduce the mosfets performance degradation. The paper is focused on the techniques to address extremely high Total Ionization Dose (TID) up to 1 Grad, which is the level required for the planned upgrade of the CERN’s LHC (HL-LHC). Today, only few data of single mosfets measurement at 1 Grad are presented in literature. These data are collected and transistors models are developed to presents, in this paper, the first system simulation results at 1 Grad conditions. As case of study, the performance reduction of two full-custom D flip-flops are presented, highlighting the robustness against radiation of CML technology for high-speed applications (10 Gbps)
Design of radiation-hard MZM drivers
No full textRadiations in harsh environments can significantly affects the performance of the silicon devices. Therefore, these effects should be taken into account in the system design phase. In this paper is shown the design of two high-speed drivers for optical Mach Zehnder modulators (MZM). The two drivers are designed to address the effects of low and high Total Ionization Dose (TID) levels, in the standard 65 nm CMOS technology. The target bit rate of the two drivers is 10 Gbps. The heavy effects that TID has on p-mosfets make the CMOS logic usable only for low radiation levels. Therefore, for TID levels higher than 10 Mrad the Current Mode Logic (CML) is more suitable. The use of this approach for the High TID driver allows reducing the effects of silicon damages. On the other hand, the CMOS driver allow halves the consumption power using only the 5% of layout area compared to the CML driver
A high-speed driver for silicon photonics Mach-Zehnder modulator for high data-rate transfer of particle collision images in high-energy physics and in medical physics
Full text linkAll the High Energy Physics (HEP) experiments in modern accelerators can be seen as real-time imaging devices whose main target is the reconstruction of the trajectories of the particles generated directly in the beam interactions - e.g. interaction between proton-proton beams in the Large Hadron collider (LHC) at CERN - or in the decay of other particles. Silicon imaging sensors are segmented in pixel arrays (50 μm x 50 μm) and they are bonded to custom Front-End (FE) ASICs. The data rate generated amounts to hundreds of Gbps for each FE ASIC. Similar scenario characterized the array of detectors in nuclear medicine systems such as PET (Positron Emission Tomography) scanners. Within this scenario, the paper presents the L1-trigger processor, which acts as an image compression processor with a compression factor 40:1. The paper also presents the silicon photonic Mach Zehnder Modulator with the relevant high-speed driver to transfer the multi-Gbps data rate with a tolerance to radiation damage up to 1 Grad
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