56 research outputs found
Effect of ibuprofen and acetylsalicylic acid on cognitive decline, total antioxidant power and serum isoprostanes [Efecto del ibuprofeno y ácido acetilsalicílico sobre el deterioro cognitivo, poder antioxidante total e isoprostanos séricos]
No full textBackground: There is controversy about the prevention of Alzheimer's disease with nonsteroidal antiinflammatory drugs (NSAIDs). Our objective was to evaluate the effect of ibuprofen and acetylsalicylic acid on cognitive impairment, serum total antioxidant power (TAP) and isoprostane (8-iso-PGF2á). Methods: We applied from April 2004 to February 2006 a Folstein mini-mental state (MMSE), Syndrome Kurtz Test (SKT) and a geriatric depression scale (Yasevage) to eighteen eligible women. They were 55 years and older. All women (n=18) with normal cognitive state were randomized to ibuprofen 400 mg per day (n=9) and acetylsalicylic acid 500 mg per day (n=9) for one year. Serum TAP and 8-iso-PGF2á were performed at baseline, after six months and one year of treatment. Results: After one year of treatment with acetylsalicylic acid five women (55.6%) raised their score 4 points in MMSE compared with 3 points increased (33.3%) showed by the ibuprofen group. TAP increased (p=0.01) and 8-iso-PGF2á reduced (p=0.01) in both groups compared with baseline. Conclusions: Both drugs improved the cognitive state and oxidative status of our population
Effect of ibuprofen and acetylsalicylic acid on cognitive decline, total antioxidant power and serum isoprostanes [Efecto del ibuprofeno y ácido acetilsalicílico sobre el deterioro cognitivo, poder antioxidante total e isoprostanos síricos]
No full textBackground: There is controversy about the prevention of Alzheimer's disease with nonsteroidal antiinflammatory drugs (NSAIDs). Our objective was to evaluate the effect of ibuprofen and acetylsalicylic acid on cognitive impairment, serum total antioxidant power (TAP) and isoprostane (8-iso-PGF2 ). Methods: We applied from April 2004 to February 2006 a Folstein mini-mental state (MMSE), Syndrome Kurtz Test (SKT) and a geriatric depression scale (Yasevage) to eighteen eligible women. They were 55 years and older. All women (n=18) with normal cognitive state were randomized to ibuprofen 400 mg per day (n=9) and acetylsalicylic acid 500 mg per day (n=9) for one year. Serum TAP and 8-iso-PGF2 were performed at baseline, after six months and one year of treatment. Results: After one year of treatment with acetylsalicylic acid five women (55.6%) raised their score 4 points in MMSE compared with 3 points increased (33.3%) showed by the ibuprofen group. TAP increased (p=0.01) and 8-iso-PGF2 reduced (p=0.01) in both groups compared with baseline. Conclusions: Both drugs improved the cognitive state and oxidative status of our population
Multiple sclerosis in Mexico: A multicentre study [Esclerosis múltiple en México: Un estudio multicéntrico]
No full textIntroduction. Multiple sclerosis (MS) is considered to be a low prevalence disease in Mexico; its characteristics have been described in isolated studies in small populations concentrated in a single region of the country and using heterogeneous methodological tools. Aims. In this study, our aim was define the clinical profile and some socio-demographic aspects of MS in Mexico using validated homogeneous criteria and tools. Patients and methods. Eight hospitals representing the five most densely populated regions of the country, the north, centre and south of Mexico, took part in the study. Data were obtained through a survey created, validated and published in Spanish (κ-interobserver 0.73 and κ-intraobserver 0.76), which consisted of 142 questions arranged in 10 sections and which was applied by 12 neurologists. The procedure was verified with 50 randomly selected surveys. A total of 337 surveys were applied, which were analysed by descriptive statistics using the EPIINFO, version 6.04b, software application. All the patients presented MS that had been clinically defined with the help of paraclinical studies according to Schumaher and Poser's criteria. Results. A sample of 337 patients was studied; 99.1% were mestizos, with an average age of 37 ± 9years, 69.7% were females and 30.3% males. 95% had access to the Social Security system and 96% had been born in Mexico to Mexican parents. No cases were found among native Mexicans. The clinical profile of the disease did not differ to that reported in other countries; the pattern observed corresponded to that found in northern latitudes. Conclusion. This is the first multicentre study carried out in Mexico with a population that is highly representative of the whole country and with a homogeneous methodology
Multiple sclerosis in Mexico: A multicentre study [Esclerosis múltiple en México: Un estudio multicéntrico]
No full textIntroduction. Multiple sclerosis (MS) is considered to be a low prevalence disease in Mexico; its characteristics have been described in isolated studies in small populations concentrated in a single region of the country and using heterogeneous methodological tools. Aims. In this study, our aim was define the clinical profile and some socio-demographic aspects of MS in Mexico using validated homogeneous criteria and tools. Patients and methods. Eight hospitals representing the five most densely populated regions of the country, the north, centre and south of Mexico, took part in the study. Data were obtained through a survey created, validated and published in Spanish (?-interobserver 0.73 and ?-intraobserver 0.76), which consisted of 142 questions arranged in 10 sections and which was applied by 12 neurologists. The procedure was verified with 50 randomly selected surveys. A total of 337 surveys were applied, which were analysed by descriptive statistics using the EPIINFO, version 6.04b, software application. All the patients presented MS that had been clinically defined with the help of paraclinical studies according to Schumaher and Poser's criteria. Results. A sample of 337 patients was studied; 99.1% were mestizos, with an average age of 37 Zapotitlán 9years, 69.7% were females and 30.3% males. 95% had access to the Social Security system and 96% had been born in Mexico to Mexican parents. No cases were found among native Mexicans. The clinical profile of the disease did not differ to that reported in other countries; the pattern observed corresponded to that found in northern latitudes. Conclusion. This is the first multicentre study carried out in Mexico with a population that is highly representative of the whole country and with a homogeneous methodology
Increased fMRI signal with age in familial Alzheimer's disease mutation carriers
No full textAlthough many Alzheimer's disease (AD) patients have a family history of the disease, it is rarely inherited in a predictable way. Functional magnetic resonance imaging (fMRI) studies of nondemented adults carrying familial AD mutations provide an opportunity to prospectively identify brain differences associated with early AD-related changes. We compared fMRI activity of 18 nondemented autosomal dominant AD mutation carriers with fMRI activity in eight of their noncarrier relatives as they performed a novelty encoding task in which they viewed novel and repeated images. Because age of disease onset is relatively consistent within families, we also correlated fMRI activity with subjects' distance from the median age of diagnosis for their family. Mutation carriers did not show significantly different voxelwise fMRI activity from noncarriers as a group. However, as they approached their family age of disease diagnosis, only mutation carriers showed increased fMRI activity in the fusiform and middle temporal gyri. This suggests that during novelty encoding, increased fMRI activity in the temporal lobe may relate to incipient AD processes. � 2012 Elsevier Inc
Prevalence of cognitive impairment and depression among a population aged over 60 years in the Metropolitan Area of Guadalajara, Mexico
No full textBackground. Cognitive impairment is an important clinical issue among elderly patients with depression and has a more complex etiology because of the variable rate of neurodegenerative changes associated with depression. The aim of the present work was to examine the prevalence of cognitive impairment and depression in a representative sample of adults aged ≥ 60 years. Methods. The presented work was a cross-sectional study on the prevalence of cognitive impairment and depression. Door-to-door interview technique was assigned in condition with multistage probability random sampling to obtain subjects that represent a population of the Guadalajara metropolitan area (GMA), Mexico. Cognitive function and depression were assessed by applying standardized Mini-Mental State Examination of Folstein (MMSE) and the Geriatric Depression Scale (GDS), respectively. Results. Prevalence of cognitive impairment was 13.8% (14.5% women, 12.6% men); no significant differences by gender and retired or pensioner were found. Prevalence of depression was 29.1% (33.6% women, 21.1% men); no significant differences by retired or pensioner were found. Cognitive impairment was associated with depression (OR = 3.26, CI 95%, 2.31-4.60). Prevalence of cognitive impairment and depression is associated with: being woman, only in depression being older than 75 years being married, and a low level of education. Conclusion. Cognitive impairment and depression are highly correlated in adults aged ≥ 60. © 2012 Genaro G. Ortiz et al
Intercalation studies of zinc hydroxide chloride: Ammonia and amino acids
No full textObjective: To determine the oxidative stress markers in serum from patients with relapsing-remitting multiple sclerosis. Methods: Blood samples from healthy controls and 22 patients 15 women (7 aged from 20 to 30 and 8 were > 40 years old) and 7 men (5 aged from 20 to 30 and 2 were > 40 years old) fulfilling the McDonald Criteria and classified as having Relapsing-Remitting Multiple Sclerosis accordingly with Lublin were collected for oxidative stress markers quantification. Results: Nitric oxide metabolites (nitrates/nitrites), lipid peroxidation products (malondialdehyde plus 4-hidroxialkenals), and glutathione peroxidase activity were significantly increased in serum of subjects with relapsing-remitting multiple sclerosis in comparison with that of healthy controls. These data support the hypothesis that multiple sclerosis is a component closely linked to oxidative stress. " 2009 - IOS Press and the authors. All rights reserved.",,,,,,"10.3233/DMA-2009-0602",,,"http://hdl.handle.net/20.500.12104/43456","http://www.scopus.com/inward/record.url?eid=2-s2.0-61349193737&partnerID=40&md5=cb4552feddfcc6c371ce07d4cc30c10d",,,,,,"1",,"Disease Markers",,"3
Cost of care according to disease-modifying therapy in Mexicans with relapsing-remitting multiple sclerosis
No full textLimited data exist on the costs of care of patients with multiple sclerosis (MS) in low- to middle-income nations. The purpose of this study was to describe the economic burden associated with care of Mexican patients with relapsing-remitting MS in a representative sample of the largest institution of the Mexican public healthcare system. We analysed individual data of 492 patients (67 % women) with relapsing-remitting MS registered from January 2009 to February 2011 at the Mexican Social Security Institute. Direct costs were measured about the use of diagnostic tests, disease-modifying therapies (DMTs), symptoms control, medical consultations, relapses, intensive care and rehabilitation. Four groups were defined according to DMT alternatives: (1) interferon beta (IFNβ)-1a, 6 million units (MU); (2) IFNβ-1a, 12MU; (3) IFNβ-1b, 8MU; and (4) glatiramer acetate. All patients received DMTs for at least 1 year. The most frequently used DMT was glatiramer acetate (45.5 %), followed by IFNβ-1a 12MU (22.6 %), IFNβ-1b 8MU (20.7 %), and IFNβ-1a 6MU (11.2 %). The mean cost of a specialised medical consultation was €74.90 (US 3,579.96). No differences were found in annualised relapse rates and costs of relapses according to DMT. However, a significant difference was observed in total annual costs according to treatment groups (glatiramer acetate being the most expensive), mainly due to differences in unitary costs of alternatives. From the public institutional perspective, when equipotent DMTs are used in patients with comparable characteristics, the costs of DMTs largely determine the total expenses associated with care of patients with relapsing-remitting MS in a middle-income country. © 2013 Belgian Neurological Society
Corncob arabinoxylan for new materials
No full textLimited data exist on the costs of care of patients with multiple sclerosis (MS) in low- to middle-income nations. The purpose of this study was to describe the economic burden associated with care of Mexican patients with relapsing-remitting MS in a representative sample of the largest institution of the Mexican public healthcare system. We analysed individual data of 492 patients (67 % women) with relapsing-remitting MS registered from January 2009 to February 2011 at the Mexican Social Security Institute. Direct costs were measured about the use of diagnostic tests, disease-modifying therapies (DMTs), symptoms control, medical consultations, relapses, intensive care and rehabilitation. Four groups were defined according to DMT alternatives: (1) interferon beta (IFN?)-1a, 6 million units (MU); (2) IFN?-1a, 12MU; (3) IFN?-1b, 8MU; and (4) glatiramer acetate. All patients received DMTs for at least 1 year. The most frequently used DMT was glatiramer acetate (45.5 %), followed by IFN?-1a 12MU (22.6 %), IFN?-1b 8MU (20.7 %), and IFN?-1a 6MU (11.2 %). The mean cost of a specialised medical consultation was 74.90 (US 3,579.96). No differences were found in annualised relapse rates and costs of relapses according to DMT. However, a significant difference was observed in total annual costs according to treatment groups (glatiramer acetate being the most expensive), mainly due to differences in unitary costs of alternatives. From the public institutional perspective, when equipotent DMTs are used in patients with comparable characteristics, the costs of DMTs largely determine the total expenses associated with care of patients with relapsing-remitting MS in a middle-income country. " 2013 Belgian Neurological Society.",,,,,,"10.1007/s13760-013-0200-z",,,"http://hdl.handle.net/20.500.12104/40401","http://www.scopus.com/inward/record.url?eid=2-s2.0-84891647794&partnerID=40&md5=e91c85bf23b6b1d7624a3e6ea4d31f69",,,,,,"4",,"Acta Neurologica Belgica",,"41
Incidence and behavior of salmonella and escherichia coli on whole and sliced zucchini squash (Cucurbita pepo) fruit
No full textBackground. Cognitive impairment is an important clinical issue among elderly patients with depression and has a more complex etiology because of the variable rate of neurodegenerative changes associated with depression. The aim of the present work was to examine the prevalence of cognitive impairment and depression in a representative sample of adults aged ? 60 years. Methods. The presented work was a cross-sectional study on the prevalence of cognitive impairment and depression. Door-to-door interview technique was assigned in condition with multistage probability random sampling to obtain subjects that represent a population of the Guadalajara metropolitan area (GMA), Mexico. Cognitive function and depression were assessed by applying standardized Mini-Mental State Examination of Folstein (MMSE) and the Geriatric Depression Scale (GDS), respectively. Results. Prevalence of cognitive impairment was 13.8% (14.5% women, 12.6% men); no significant differences by gender and retired or pensioner were found. Prevalence of depression was 29.1% (33.6% women, 21.1% men); no significant differences by retired or pensioner were found. Cognitive impairment was associated with depression (OR = 3.26, CI 95%, 2.31-4.60). Prevalence of cognitive impairment and depression is associated with: being woman, only in depression being older than 75 years being married, and a low level of education. Conclusion. Cognitive impairment and depression are highly correlated in adults aged ? 60. " 2012 Genaro G. Ortiz et al.",,,,,,"10.1155/2012/175019",,,"http://hdl.handle.net/20.500.12104/43868","http://www.scopus.com/inward/record.url?eid=2-s2.0-84871364189&partnerID=40&md5=5fa023306d01b929dbed77b84512cd6e",,,,,,,,"Current Gerontology and Geriatrics Research",,,,"2012",,"Scopus",,,,,,,,,,,,"Prevalence of cognitive impairment and depression among a population aged over 60 years in the Metropolitan Area of Guadalajara, Mexico",,"Article"
"43933","123456789/35008",,"Castro-Rosas, J., Centro de Investigations Químicas, Instiruto de Ciencias Básicas e Ingeniería, Universidad Autónoma Del Estado de Hidalgo, Carretera Pachuca-Tulancingo Km. 4.5, Mineral de la reforma, Hidalgo, CP. 42183, Mexico; Santos López, E.M., Centro de Investigations Químicas, Instiruto de Ciencias Básicas e Ingeniería, Universidad Autónoma Del Estado de Hidalgo, Carretera Pachuca-Tulancingo Km. 4.5, Mineral de la reforma, Hidalgo, CP. 42183, Mexico; Gómez-Aldapa, C.A., Centro de Investigations Químicas, Instiruto de Ciencias Básicas e Ingeniería, Universidad Autónoma Del Estado de Hidalgo, Carretera Pachuca-Tulancingo Km. 4.5, Mineral de la reforma, Hidalgo, CP. 42183, Mexico; Ramírez, C.A.G., Centro de Investigations Químicas, Instiruto de Ciencias Básicas e Ingeniería, Universidad Autónoma Del Estado de Hidalgo, Carretera Pachuca-Tulancingo Km. 4.5, Mineral de la reforma, Hidalgo, CP. 42183, Mexico; Villagomez-Ibarra, J.R., Centro de Investigations Químicas, Instiruto de Ciencias Básicas e Ingeniería, Universidad Autónoma Del Estado de Hidalgo, Carretera Pachuca-Tulancingo Km. 4.5, Mineral de la reforma, Hidalgo, CP. 42183, Mexico; Gordillo-Martínez, A.J., Centro de Investigations Químicas, Instiruto de Ciencias Básicas e Ingeniería, Universidad Autónoma Del Estado de Hidalgo, Carretera Pachuca-Tulancingo Km. 4.5, Mineral de la reforma, Hidalgo, CP. 42183, Mexico; López, A.V., Laboratorio de Microhiología Sanitaria, Centra Universitario de Ciencias Exactas e Ingeniería, Universidad de Guadalajara, Marcelino García Barragán 1451, Guadalajara 44430, Mexico; Del Refugio Torres-Vitela, M., Laboratorio de Microhiología Sanitaria, Centra Universitario de Ciencias Exactas e Ingeniería, Universidad de Guadalajara, Marcelino García Barragán 1451, Guadalajara 44430, Mexico",,"Castro-Rosas, J
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