4,718 research outputs found
Database for: Excavations at Tall Jawa, Jordan: Volume 3, The Iron Age Pottery
No full textThis is a Microsoft Access database of imagery, drawings, and photos accompanying Excavations at Tall Jawa, Jordan: Volume 3, The Iron Age Pottery by P.M. Michèle Daviau. The text and database present a detailed typology of the Iron Age pottery excavated from 1989 to 1995. Together, they represent an in-depth analysis of the forming techniques employed to make each type of vessel from bowls to colanders, cooking pots to pithoi.
The digital archive is a work in progress by the author. The archive currently holds the collection for Excavation Field D. Upon completion, it will include seven collections, each one consisting of a database of diagnostic sherds and vessels as well as the images of these pots as .tiff files. Databases are related to excavation fields and are designed for meaningful searches: A, B, C-east, C-west, A-east (associated with C-west), D and E
IoWoman, March/April 2004, Vol. 34, no. 2
No full textNewsletter for the Iowa Commission on the Status of Wome
IoWoman, March/April 2004, Vol.34, no.2
No full textNewsletter for the Iowa Commission on the Status of Wome
Old Fashioned Ice Cream Social at the U of M, Crookston Features Author Gayla Marty on Wed., Aug. 18, 2010, from 2-4 p.m.
No full textTollefson, Elizabeth. (2010). Old Fashioned Ice Cream Social at the U of M, Crookston Features Author Gayla Marty on Wed., Aug. 18, 2010, from 2-4 p.m.. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/222491
Our Mission and our Values' : an approach to Russian Banks' Communication Strategies
No full textThis paper looks at the mission statements of Russian banks posted on their websites with the aim of identifying recurrent discursive strategies in an intercultural perspective. Starting from the surveyof twenty websites of Russian banks, the author attempts to highlight the linguistic and visual treatment of mission and value statements, where there seems to emergean interesting mix of both "globalized" and local, culture-specific, features
La politica linguistica nei paesi della CSI
No full textThe paper deals with language status and language use in post Soviet Republics. After a brief introduction to Soviet language policy, the author deals with data from the National census, about the number of Russian speakers in these areas in the years 1989-1991 and in 2004-2006. Other data regard the use of Russian language, as opposed to/or in accordance with titular languages, in different social spheres (education, media, institutions)
Author David Halberstam Available for Interviews Tuesday
No full textLegendary journalist and author David Halberstam, who speaks at 7 p.m. Tuesday (April 20) in the Johnson Commons Ballroom, will be available for interviews earlier that afternoon. The media session is set for 3:30 p.m. in the Bondurant Hall lounge, located on the second floor. No advance credentials are required
Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease
No full textPolyglutamine diseases are a class of dominantly inherited neurodegenerative disorders for which there is no effective treatment. Here we provide evidence that activation of serotonergic signalling is beneficial in animal models of Machado-Joseph disease. We identified citalopram, a selective serotonin reuptake inhibitor, in a small molecule screen of FDA-approved drugs that rescued neuronal dysfunction and reduced aggregation using a Caenorhabditis elegans model of mutant ataxin 3-induced neurotoxicity. MOD-5, the C. elegans orthologue of the serotonin transporter and cellular target of citalopram, and the serotonin receptors SER-1 and SER-4 were strong genetic modifiers of ataxin 3 neurotoxicity and necessary for therapeutic efficacy. Moreover, chronic treatment of CMVMJD135 mice with citalopram significantly reduced ataxin 3 neuronal inclusions and astrogliosis, rescued diminished body weight and strikingly ameliorated motor symptoms. These results suggest that small molecule modulation of serotonergic signalling represents a promising therapeutic target for Machado-Joseph disease.This work was supported by Fundação para a Ciência e Tecnologia (FCT) and COMPETE through the projects ‘[PTDC/SAU-GMG/112617/2009] (to P.M.) and [EXPL/ BIM-MEC/0239/2012] (to A.T.C.)’, by National Ataxia foundation (to P.M.), by Ataxia UK (to P.M.), by National Institutes of Health (NIH) ‘[GM038109, GM081192, AG026647, and NS047331] (to R.I.M.)’, by The Chicago Biomedical Consortium (to R.I.M.) and by the Ellison Medical Foundation (to R.I.M.). A.T.C., A.J., S.E., L.S.S., C.B., S.D.S., A.S.F. and A.N.C. were supported by the FCT individual fellowships SFRH/BPD/79469/2011, SFRH/BD/76613/2011, SFRH/BD/78554/2011, SFRH/BD/ 84650/2012, SFRH/BPD/74452/2010, SFRH/BD/78388/ 2011, SFRH/BPD/91562/2012 and SFRH/BD/51059/2010, respectively. FCT fellowships are co-financed by POPH, QREN, Governo da República Portuguesa and EU/FSE.info:eu-repo/semantics/publishedVersio
Citalopram reduces aggregation of ATXN3 in a YAC transgenic mouse model of Machado-Joseph disease
No full textMachado-Joseph disease, also known as spinocerebellar ataxia type 3, is a fatal polyglutamine disease with no disease-modifying treatment. The selective serotonin reuptake inhibitor citalopram was shown in nematode and mouse models to be a compelling repurposing candidate for Machado-Joseph disease therapeutics. We sought to confirm the efficacy of citalopram to decrease ATXN3 aggregation in an unrelated mouse model of Machado-Joseph disease. Four-week-old YACMJD84.2 mice and non-transgenic littermates were given citalopram 8 mg/kg in drinking water or water for 10 weeks. At the end of treatment, brains were collected for biochemical and pathological analyses. Brains of citalopram-treated YACMJD84.2 mice showed an approximate 50% decrease in the percentage of cells containing ATXN3-positive inclusions in the substantia nigra and three examined brainstem nuclei compared to controls. No differences in ATXN3 inclusion load were observed in deep cerebellar nuclei of mice. Citalopram effect on ATXN3 aggregate burden was corroborated by immunoblotting analysis. While lysates from the brainstem and cervical spinal cord of citalopram-treated mice showed a decrease in all soluble forms of ATXN3 and a trend toward reduction of insoluble ATXN3, no differences in ATXN3 levels were found between cerebella of citalopram-treated and vehicle-treated mice. Citalopram treatment altered levels of select components of the cellular protein homeostatic machinery that may be expected to enhance the capacity to refold and/or degrade mutant ATXN3. The results here obtained in a second independent mouse model of Machado-Joseph disease further support citalopram as a potential drug to be repurposed for this fatal disorder.This work was funded by Becky Babcox Research
Fund/pilot research award G015617, University of Michigan to M.C.C.
and NINDS/NIH R01NS038712 to H.L.P. The work performed at the
University of Minho was funded by the European Regional
Development Funds (FEDER), through the Competitiveness Factors
Operational Programme (COMPETE), and by National funds, through
the Foundation for Science and Technology (FCT), under the scope of the
project POCI-01-0145-FEDER-007038. This article was developed under the scope of the project NORTE-01-0145-FEDER-000013, supported
by the Northern Portugal Regional Operational Program (NORTE 2020),
under the Portugal 2020 Partnership Agreement, through the FEDER.
This work was also supported by FCT and COMPETE through the projects [PTDC/SAU-GMG/112617/2009] (to P.M.) and [EXPL/BIM-MEC/
0239/2012] (to A.T.C.); by FCT through the project [POCI-01-0145-
FEDER-016818 (PTDC/NEU-NMC/3648/2014)] (to P.M.); by National
Ataxia Foundation (to P.M. and to A.T.C.); and by Ataxia UK (to P.M.).
S.D.S. and A.T.C. were supported by fellowships from FCT, SFRH/BD/
78388/2011 and SFRH/BPD/102317/2014, respectively. FCT fellowships are co-financed by POPH, QREN, Governo da República
Portuguesa and EU/FSE
"Popular author, poet to read at OU"
No full textNews article"One of America's most popular writers will visit OU Friday, Oct. 18. Marge Piercy, award winning author and poet, will read from her poetry at 4 p.m. in 201 Dodge Hall.
- …
