1,744 research outputs found
Interview with Jean Francois Revel, author
No full textJean Francois Revel, the author of Without Marx or Jesus, has been quoted as saying, "The United States is now a microcosm for all of the problems man faces." In this interview with Meredith Watts, he discusses a new kind of revolution which could produce successful change without violent upheavalGrayscaleSoun
Beauregard House
No full textGeneral view; The architect Francois Correjolles, whose creole French family emigrated from St. Domingue (Haiti), added new American Federal elements while preserving some of the traditional creole plan. The Beauregard-Keyes House, built in 1826 for wealthy auctioneer Joseph Le Carpentier, is a fine example of a raised, center-hall house. It is named for two of its former tenants, Confederate General Pierre Gustave Toutant (P.G.T.) Beauregard and author Frances Parkinson Keyes. General Beauregard lived in the home from 1866 to 1868 while he was president of the New Orleans, Jackson, and Great Northern Railroad. The home features twin curved staircases, leading to a Tuscan portico. The garden's design duplicates the original 1865 plans. (Common Routes: St. Domingue-Louisiana exhibition, 2006) Source: Historic New Orleans Collection [website]; http://www.hnoc.org/ (accessed 1/24/2008
Alien theory : the decline of materialism in the name of matter
No full textThe thesis tries to define and explain the rudiments of a 'nonphilosophical'
or 'non-decisional' theory of materialism on the basis of a
theoretical framework provided by the 'non-philosophy' of Francois
Laruelle. Neither anti-philosophical nor anti-materialist in character, non-materialism
tries to construct a rigorously transcendental theory of matter by
using certain instances of philosophical materialism as its source material.
The materialist decision to identify the real with matter is seen to retain a
structural isomorphy with the phenomenological decision to identify the real
with the phenomenon. Both decisions are shown to operate on the basis of a
methodological idealism; materialism on account of its confusion of matter
and concept; phenomenology by virtue of its confusion of phenomenon and
logos. By dissolving the respectively 'materiological' and
'phenomenological' amlphibolies which are the result of the failure to effect a
rigorously transcendental separation between matter and concept on the one
hand; and between phenomenon and logos on the other, non-materialist
theory proposes to mobilise the non-hybrid or non-decisional concepts of a
'matter-without-concept' and of a 'phenomenon-without-logos' in order to
effect a unified but non-unitary theory of phenomenology and materialism.
The result is a materialisation of thinking that operates according to matter's
foreclosure to decision. That is to say, a transcendental theory of the
phenomenon that licenses limitless phenomenological plasticity,
unconstrained by the apparatus of eidetic intuition or any horizon of
apophantic disclosure; yet one which is simultaneously a transcendental
theory of matter, uncontaminated by the bounds of empirical perception and
free of all phenomenological circumscription
Direct activation of Ca2+ and voltage-gated potassium channels of large conductance by anandamide in endothelial cells does not support the presence of endothelial atypical cannabinoid receptor
No full textEndocannabinoid anandamide induces endothelium-dependent relaxation commonly attributed to stimulation of the G-protein coupled endothelial anandamide receptor. The study addressed the receptor-independent effect of anandamide on large conductance Ca(2+)-dependent K(+) channels expressed in endothelial cell line EA.hy926. Under resting conditions, 10 microM anandamide did not significantly influence the resting membrane potential. In a Ca(2+)-free solution the cells were depolarized by ~10 mV. Further administration of 10 microM anandamide hyperpolarized the cells by ~8 mV. In voltage-clamp mode, anandamide elicited the outwardly rectifying whole-cell current sensitive to paxilline but insensitive to GDPbetaS, a G-protein inhibitor. Administration of 70 microM Mn(2+), an agent used to promote integrin clustering, reversibly stimulated whole-cell current, but failed to further facilitate the anandamide-stimulated current. In an inside-out configuration, anandamide (0.1-30 microM) facilitated single BKCa channel activity in a concentration-dependent manner within a physiological Ca(2+) range and a wide range of voltages, mainly by reducing mean closed time. The effect is essentially eliminated following chelation of Ca(2+) from the cytosolic face and pre-exposure to cholesterol-reducing agent methyl-beta-cyclodextrin. O-1918 (3microM), a cannabidiol analog used as a selective antagonist of endothelial anandamide receptor, reduced BKCa channel activity in inside-out patches. These results do not support the existence of endothelial cannabinoid receptor and indicate that anandamide acts as a direct BKCa opener. The action does not require cell integrity or integrins and is caused by direct modification of BKCa channel activity
The ethical and moral-based dimension of leadership in CSR-oriented strategies and sustainable entrepreneurship
No full textThis chapter addresses the theme of leadership and its influence on corporate social
responsibility (CSR) and sustainability-oriented strategies. Specifically, it aims to analyse,
through a deductive and literature-based approach, the relevance of the ethical and moral
leadership models with respect to the diffusion of CSR and sustainable entrepreneurship. Linking ethical and moral-based leadership to the CSR and sustainable entrepreneurship discourse allows us to point out the relevance of an authentic orientation in supporting
change and fostering sustainable entrepreneurship The theoretical construct of responsible and sustainable leadership derives from the
intersection of the moral-based leadership concepts with those of CSR and sustainable
entrepreneurship..Drawing from these premises, this chapter seeks to identify leadership models and
attributes consistent with (and necessary to develop) an authentic CSR-oriented strategy
and able to foster sustainable entrepreneurship.
Accordingly, in this chapter, we argue that leadership represents a key aspect that
warrants more research within both CSR and sustainable entrepreneurship studies. The
research questions that orients this study can be summarised as follows: Which leadership
models favour authentic CSR practices? Are moral, ethical-based and virtues-based models
of leadership effective in developing CSR and fostering sustainable entrepreneurship?
These questions guide the critical review of the different leadership approaches, bringing
attention to the models that are most coherent in regard to the actual socio-economic
context which requires managers and entrepreneurs to govern the internal and external
complexity and actively contribute to sustainability. The methodological approach is
mainly based on a literature review that surveys critical points in current literature that is
relevant to the topic.
The work is structured as follows. First, we offer an analysis of the leadership theoretical
framework in the context of the CSR debate. We begin with a brief methodological
note, followed by an analysis of the antecedents of CSR and sustainable entrepreneurship
in terms of values and virtues.
Second, a review of relevant literature on leadership approaches and models consistent
with the CSR and sustainable entrepreneurship discourse is presented, emphasising the relationship between transformational, moral and virtues-based leadership and
CSR-oriented strategies and sustainable entrepreneurship. Drawing from the analysis,
four main propositions are introduced. The final sections illustrate the propositions and
summarise the implications and limitations of the study
The medieval forms and meanings of Francois: The political and cultural vicissitudes of an ethnonym
No full textThe article looks at the evolution of the ethnonym Francois in the Middle Ages and its significance to Germanic peoples known as Franks in the context of their cross-cultural relations with Muslim, Byzantine and British people. The author analyzes chronicles of the First Crusade and examines the use of Francois as an exonym and an autonym, and its role in the development of the French identity
New concepts in the management of dyslipidaemiaa.
No full textRecently, the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS) published a consensus paper giving guidance on the definition and management of statin-associated muscle symptoms (SAMS), as well as the use of proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors in very high-risk patients. The occurrence of SAMS can have a major negative impact on treatment adherence and, consequently, on the prognosis of cardiovascular diseases. In addition, both the ESC guidelines on the prevention of cardiovascular disease (CVD) in clinical practice with sections addressing global strategies to minimise the burden of CVD at population and individual levels, and the 2016 ESC/EAS guideline for the management of dyslipidaemias, focus on evaluation and treatment of SAMS. The release of these guidelines was a source of great interest to clinicians, as new emergent therapies, such as the PCSK9 inhibitors, have been approved for the treatment of dyslipidaemias: recently, both the US Food and Drugs Administration (FDA) and the European Medicines Agency (EMA) approved the use of PCSK9 inhibitors as add-ons for the treatment of hypercholesterolaemia in cases where low-density lipoprotein cholesterol (LDL-C) target levels could not be reached with maximum tolerated statin doses alone, or instead of statins in the event of SAMS. Because of the relatively high cost of these new therapies, physicians need to justify the use of PCSK9 inhibitors by demonstrating that their high-risk patients' LDL-C levels have remained high (1) despite a well-conducted, but insufficiently effective high-intensity statin therapy (e.g. rosuvastatin 10-20 mg or atorvastatin 40-80 mg), or (2) in the event of the patient developing side effects, in particular severe SAMS, during treatment with at least three statins. In addition to SAMS, the use of PCSK9 inhibitors may be considered in patients with documented atherosclerotic cardiovascular disease or in patients with familial hypercholesterolaemia and poorly controlled LDL-C under the combination of maximum tolerated stain and ezetimibe
Henri Matisse Drawing: An Eye-Hand Interaction Study Based on Archival Film.
No full textHenri Matisse (1869-1954) attached fundamental importance to his drawings, in particular to the famous Themes et Variations series. These were accomplished following a precise method, starting with arduous life studies and evolving into brilliant spontaneous drawings. A 1946 archival documentary film showing the artist drawing four portraits of his grandson Gerard was shot in such a way as to allow the present author to undertake a detailed eye-hand interaction analysis of the drawing process.
It was found that Matisse’s temporal working rhythm and use of motor memory resulted in a more direct approach than that used by most painters. Taken together with remarks the artist made throughout his lifetime, these results provide a cognitive interpretation of his drawing method
Francois Ludger Diard poetry notebook and Mobile scrapbook, W.0025
No full textAbstract: Notebook of this Mobile, Alabama, native's poetry and a scrapbook of newspaper clippings and letters relating to his work.Scope and Content Note: This collection contains a notebook of Diard's poetry and a scrapbook of newspaper clippings and letters relating to his work. Diard annotated many of the poems collected in this 200-page notebook, noting when they were written and/or published. The majority of the notebook contains clippings of poetry published by local newspapers during World War I. Most of these poems are patriotic, praising the sacrifices of Alabama servicemen. Toward the back of the volume are several letters to Diard from the vice-president of the
Mobile Register, Erwin Craighead, soliciting poems for an anthology of Mobile literati.The Mobile scrapbook contains newspaper items clipped from the
Mobile Register, the
Mobile Times, and other Mobile newspapers. The articles were published between 1849 and 1945, with most of the articles published between 1929 and 1945. While most of the items address city events and Mobile's literary community, other items include obituaries and state and national news briefs. Approximately one-quarter of the articles clipped are copies of Erwin Craighead's column "Dropped Stitches From Mobile's Past."Biographical/Historical Note: Francois Ludger Diard, son of Charles August R. and Sarah Antonia Ludgere Diard, was born on 29 October 1883 in Mobile, Alabama. He was the author of many poems, including "We Have Kept the Faith," a response to "We Shall Not Sleep, Tho Poppies Grow in Flanders Fields" written by Lieutenant Colonel Dr. John McRae of Canada while the second battle of Ypres, Belgium, was in progress. He also wrote
The Tree: Being the Strange Case of Charles R. S. Boyington about the 1835 Mobile murder of Nathaniel Frost by Charles Boyington. Diard died in Mobile on 25 March 1955
Finite time lyapunov exponents and extreme concentration fluctuations in 2d turbulence
No full textThe statistics of the Finite time Lyapunov exponent (FTLE) has been investigated in detail in laboratory 2D flows. The balance of the forward and backward FTLE suggests the incompressible nature of the turbulence in both the electromagnetic and Faraday wave driven experiments. The tail in the PDF of the FTLE field is correlated with the extreme concentration of the passive scale, the ‘unmixing’ events
- …
