203 research outputs found
Alpha and Omega, from Seneca Journal
No full text10 x 15 cm.Postcard of poem 'Alpha and Omega' by Jerome Rothenberg, with letter by author to David Meltzer on back, ca. 1974. 10 x 15 cm
The Anthology as a Manifesto & as an Epic Including Poetry, or the Gradual Making of Poems for the Millennium
No full textThe author discusses the making of the anthology, Poems for the Millennium, or of “the
anthology as an epic poem and/or a manifesto.” Both Jerome Rothenberg and Pierre Joris
were able to show too —if it needed showing— that multiculturalism and avantgardism
were not incompatible but historically, though not inevitably, related.El autor analiza la construcción de la antología, Poems for the Millennium, o su considera-
ción “de la antología como poema épico y/o manifiesto”. Los editores de esta antología,
Jerome Rothenberg y Pierre Joris supieron mostrar —por si ello fuese necesario— que el
multiculturalismo y el vanguardismo no eran incompatibles sino que estaban, aunque no
de manera inevitable, históricamente relacionados
A balance sheet of life.
No full textThe memoirs were written 1998 in London. The author describes the Rothenberg family's history going back to the late 18th century. Helmut Rothenberg's great-grandfather Emil Rothenberg was born 1853 in Goettingen. His mother died three years later, and Emil was brought up with relatives. In 1879 Emil Rothenberg married Fanny Karpf, whose ancestors came from southern Germany. Emil and Fanny lived in Nuernberg and had seven children. Their oldest son Isaak, the author's father, was born in 1880. He became a senior manager at the brass works of Aron Hirsch & Son in Halberstadt. In 1914 Isaak Rothenberg married Dora Moses, who came from a large orthodox family. Isaak and Dora Rothenberg had two sons; Helmut, born in 1915, was the oldest. His brother Karl-Heinz was born in 1917. In 1920 the family moved to Frankfurt, where Isaak Rothenberg joined a manufacturing business. Memories of the Rhineland occupation by French troops and the time of inflation after World War I. Helmut attended "Musterschule", a school based on Johann Pestalozzi's principles of education. School trip to London in 1930. Private piano lessons and growing interest in music. Rising Nazism. Helmut Rothenberg graduated in 1933, shortly after Hitler had become chancellor of Germany. A few months later he left Frankfurt for England. He stayed with friends of his father in Cheshunt, where he started to work as a chartered accountant. Helmut's brother Heinz (Henry) joined him in 1934, as the condition in his school in Frankfurt had become intolerable. Summer vocations with their parents in Suffolk. In 1939 Isaak and Dora Rothenberg were able to emigrate to England - shortly before the outbreak of war with Germany. Henry joined the Pioneer Corps in 1939, while Helmut worked for the War Office. The family moved to London in 1940. Recollection of air raids and situation as enemy aliens.Helmut Rothenberg started his own business in 1945, and shortly thereafter he married his fiancée Annema Hannes. In 1946 their son John Daniel was born. Description of his professional accomplishments. Memories of colleagues and friends. Their second son Robert Michael was born in 1950.Helmut Rothenberg was born in 1915 in Halberstadt, Germany. He emigrated to England in March 1933, where he started work as a chartered accountant. His brother Henry joined him in 1934. Their parents Isaak and Dora Rothenberg managed to emigrate to England shortly before the outbreak of war with Germany in 1939. In 1945 Helmut married Annema Hannes, a former medical student and Jewish émigré from Breslau. They had three children together and two children from Annema's previous marriage.Synopsis in fileChildhoodIn 1959 Judith Kay was born. Their children and grandchildren live in London, Israel and New York
Safety Analysis of FOLFOX4 Treatment in Colorectal Cancer Patients: A Comparison Between Two Asian Studies and Four Western Studies
No full textFOLFOX4 (5-fluorouracil, leucovorin, and oxaliplatin) is a standard regimen for the treatment of advanced colorectal cancer. Its dose intensity and safety profile were compared between 2 Asian and 4 Western studies by analyzing 3359 patients. There was no evidence that Asian patients experienced worse toxicity than Western patients, and trends toward reduced neurotoxicity and diarrhea among Asian patients were observed.
Purpose: Oxaliplatin-based therapy, notably FOLFOX4 (5-fluorouracil, leucovorin, and oxaliplatin), is a standard regimen approved globally for the treatment of metastatic colorectal cancer, and as adjuvant treatment of colon cancer. As part of the Japanese submission for the adjuvant indication, the safety profile of FOLFOX4 regimen was compared in Asian and Western patients. Patients and Methods: A total of 3359 patients with colorectal cancer treated with the FOLFOX4 regimen were included in the analyses: 1515 from 2 Asian studies (Japanese Post Marketing Surveillance and Multicenter Asia Study in Adjuvant Treatment of Colon Cancer with Oxaliplatin/5-FU/LV), and 1844 from 4 Western studies (EFC2962, N9741, EFC4584, and Multicenter International Study of Oxaliplatin/5-Fluorouracil/Leucovorin in the Adjuvant Treatment of Colon Cancer). Doses administered and safety parameters were analyzed by using common definitions and programs. Results: Demographic and baseline characteristics were comparable between Asian and Western patients. Patients received FOLFOX4 for a median of 6-12 cycles, which ranged from 16 to 28 weeks. Median dose intensities of oxaliplatin and of 5-fluorouracil, bolus and infusion, were within the ranges of 33 to 36 mg/m(2)/week, 297 to 338 mg/m(2)/week, and 467 to 510 mg/m(2)/week, respectively. Most frequently reported adverse events (AE) included hematologic, gastrointestinal, and neurosensory adverse events (NSAE). The incidence of grade neutropenia ranged from 37% (422 of 1134) to 52% (83 of 159) in Asian and 41% (455 of 1108) to 56% (144 of 259) in Western studies; of diarrhea, ranged from 1.4% (3 of 222) to 6.3% (10 of 159) and 11% (30 of 268 or 120 of 1108) to 14% (36 of 259); of NSAEs, from 1.9% (21 of 1134) to 4.4% (7 of 159) and 9.3% (25 of 268) to 19% (39 of 209); and of allergic reactions, from 0.6% (7 of 1134) to 3.1% (5 of 159) and 1.1% (3 of 268) to 3.0% (33 of 1108), respectively. The probability of grade >= 3 NSAEs and diarrhea was statistically significantly lower in Asian than in Western studies by using a log-rank test. Conclusion: There was no evidence that Asian patients experienced worse toxicity than did Western patients when treated with FOLFOX4, and trends toward reduced neurotoxicity and diarrhea among Asian patients were observed
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