22,313 research outputs found
Individualized immunosuppression in transplant patients: potential role of pharmacogenetics.
No full textThe immunosuppressive drugs used to prevent the rejection of transplanted organs have a narrow therapeutic index. Under treatment results in episodes of rejection leading to either damage or loss of the organ. Over immunosuppression increases the risk of infection and malignancy as well as drug specific complications including diabetes mellitus and nephrotoxicity. There is wide variation in the drug dose required to achieve target blood concentrations and there is often dissociation between pharmacokinetics and pharmacodynamics. Currently, immunosuppressive drug treatment is individualized based on a clinical assessment of the risk of rejection or toxicity. Therapeutic drug monitoring is routinely employed for several immunosuppressive drugs. Pharmacogenetics has the potential to complement therapeutic drug monitoring but clinical benefit has yet to be demonstrated. Novel biomarker-based approaches to risk stratification and pharmacodynamic monitoring are under development and are ready for clinical trials
CE Challenges: Work to Do
No full textCE has been used for more than two decades now. Despite many successes and advantages, there are still many challenges to be addressed. These challenges are both technical and organisational. In the paper we will address the current challenges of CE. Many challenges are related to the exchange of data and knowledge and to the systems that make data and knowledge exchange possible. Although much progress has been made in enabling extensive data and knowledge exchange and use, much remains to be wished. For example, there are still barriers to data exchange. Technically, these barriers may consist of different formats, differences in infrastructures and systems, and different semantics. There are also organisational and political barriers. For example, investment in information system may heavily impact upstream suppliers, while revenues of better information exchange may predominantly be gained by downstream actors. Without sharing costs and revenues, chain-wide information exchange will not be easily realised. Another barrier is the possible lack of willingness to share information, because of potential misuse of knowledge and loss of power. The paper is organised as follows. First we will describe the current manifestation of CE as described in a recent book. Second, we will list current trends in CE. Third, we will present some Critical Success Factors (CSFs) that are considered relevant for implementing and adapting CE practices. Last, we indicate some research and practical questions to be addressed, especially for areas that have a high potential and actual impact. </p
Fig. 19. Isolated p4 in A Possible Heptaxodontine and Other Caviidan Rodents from the Quaternary of Jamaica
No full textFig. 19. Isolated p4 (AMNHP 140816) of capromyid Isolobodon portoricensis from Salt River Bay, St. Croix (?Amerindian site), SEMs at low and high magnification. (A) Transverse section at low magnification, showing distribution of enamel (en), dentine (de), and cementum (ce). (B) Closeup of large boxed area in A, showing cementum and enamel. (C) Closeup of small boxedPublished as part of MacPhee, R. D. E. & Flemming, Clare, 2003, A Possible Heptaxodontine and Other Caviidan Rodents from the Quaternary of Jamaica, pp. 1-43 in American Museum Novitates 3422 on page 34, DOI: 10.1206/0003-0082(2003)4222.0.co;2, http://zenodo.org/record/505674
Synthesis optimization and charge carrier transfer mechanism in LiLuSiO<sub>4</sub>:Ce, Tm storage phosphor
No full textLiLuSiO4:Ce and LiLuSiO4:Ce, Tm show very efficient charge carrier storage properties upon beta irradiation after samples have received treatment in vacuum. They outperform the commercial storage phosphor BaFBr(I):Eu2+ in many aspects. The influence of the synthesis conditions, Ce and Tm concentration, nonstoichiometry and codoping with Ca, Hf, Al and Ge are reported. Based on the results of the synthesis optimization, thermoluminescence (TL) emission and TL excitation spectra a mechanism of charge carrier transfer, storage, and recombination during irradiation and thermal or optical readout is proposed.Accepted Author ManuscriptRST/Fundamental Aspects of Materials and EnergyRST/Luminescence Material
Kindergarten teachers’ notions of parent involvement and perceived challenges
No full textWe examine how kindergarten teachers on Prince Edward Island depict both parent involvement in school and its perceived challenges. Data consisted of written responses to two open-ended survey questions completed by 62 participants or 94% of the kindergarten teachers on PEI. Results showed that teachers recognized parent involvement in traditional forms. Barriers included lack of educator time and unproductive school policies. Extending from Epstein’s parent involvement model, if increasingly rich forms of parent involvement are to actualize, educators must be attuned to family vibrancy — the diverse gifts each family possesses; family vibrancy includes the belief that every parent, regardless of socioeconomic status, language abilities, ethnicity, religion, etc., can and does support his/her child’s education to the best of his/her ability.
CONCEPTIONS DES ENSEIGNANTS AU PRÉSCOLAIRE EN LIEN AVEC L’ENGAGEMENT PARENTAL ET DÉFIS PERÇUS
Dans cet article, nous présentons la manière dont des enseignants au préscolaire de l’Île-du-Prince-Édouard (Canada) décrivent l’engagement parental à l’école et les défis perçus en lien avec cet engagement. Les données utilisées sont des réponses écrites à un sondage composé de deux questions ouvertes et complété par 62 participants, soit 94 % des enseignants au préscolaire de l’IPÉ. Les résultats montrent que les enseignants conçoivent l’engagement parental sous ses formes traditionnelles et identifient le manque de temps d’enseignement et les politiques scolaires non productives comme des obstacles. En nous basant sur le modèle d’Epstein de l’engagement parental et dans un contexte où les parents seront amenés à s’impliquer davantage dans des contextes plus riches, il semble nécessaire que les enseignants soient plus ouverts à la vitalité de chaque famille — les talents que chaque famille possède. Ce concept reconnaît que tous les parents, quel que soit leur situation socio-économique, leur maîtrise de la langue, leurs habiletés, leur origine ethnique, leur religion, leur situation d’emploi, leur âge, leur genre, etc. peuvent soutenir et soutiennent l’éducation de leur enfant au meilleur de leurs capacités
The impact of P(NDI2OD-T2) crystalline domains on the open-circuit voltage of bilayer all-polymer solar cells with an inverted configuration
No full textWe fabricated P(NDI2OD-T2)/PTB7 bilayer all-polymer solar cells with an inverted configuration, where the annealing temperature was systematically varied. The current density-voltage behavior was investigated and the structural properties of the P(NDI2OD-T2) layers were characterized. Absorption spectroscopy, surface morphology, and crystallite analysis showed that increasing phase segregation of P(NDI2OD-T2) films occurred as the annealing temperature increased. We found that, as the P(NDI2OD-T2) stacking improved, with larger domains, the open-circuit voltage decreased and the saturation dark current density increased. This work provides a guide for the processing of P(NDI2OD-T2) layers to maximize the power conversion efficiency of all-polymer solar cells. (C) 2015 Author(s).open1186sciescopu
Data and code for: Variational Graph Author Topic Modeling
No full textThis is the tensorflow implementation of KDD-2022 paper "Variational Graph Author Topic Modeling" by Delvin Ce Zhang and Hady W. Lauw.
VGATM is a Graph Neural Network model that extracts interpretable topics for documents with authors and venues. Topics of documents then fulfill document classification, citation prediction, etc.
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Updated analytical solutions of continuity equation for electron beams precipitation – I. Pure collisional and pure ohmic energy losses
No full textWe present updated analytical solutions of continuity equations for power-law beam electrons precipitating in (a) purely collisional losses and (b) purely ohmic losses. The solutions of continuity equation (CE) normalized on electron density presented in Dobranskis & Zharkova are found by method of characteristics eliminating a mistake in the density characteristic pointed out by Emslie et al. The corrected electron beam differential densities (DD) for collisions are shown to have energy spectra with the index of −(γ + 1)/2, coinciding with the one derived from the inverse problem solution by Brown, while being lower by 1/2 than the index of −γ/2 obtained from CE for electron flux. This leads to a decrease of the index of mean electron spectra from −(γ − 2.5) (CE for flux) to −(γ − 2.0) (CE for electron density). The similar method is applied to CE for electrons precipitating in electric field induced by the beam itself. For the first time, the electron energy spectra are calculated for both constant and variable electric fields by using CE for electron density. We derive electron DD for precipitating electrons (moving towards the photosphere, μ = +1) and ‘returning’ electrons (moving towards the corona, μ = −1). The indices of DD energy spectra are reduced from −γ − 1 (CE for flux) to −γ (CE for electron density). While the index of mean electron spectra is increased by 0.5, from −γ + 0.5 (CE for flux) to −γ + 1(CE for electron density). Hard X-ray intensities are also calculated for relativistic cross-section for the updated differential spectra revealing closer resemblance to numerical Fokker–Planck (FP) solutions
Introduction and Author Biographical Notes
No full textThe Introductory Notes include The Cutting EDge\u27s mission statement, editorial board, founder\u27s note, and author\u27s biographies
From the Editors and Author Biographical Notes
No full textLetter from the Editors and Author Biographical Note
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