1,721,004 research outputs found
HETEROCYCLIC COMPOUNDS AND MEDICAL USE THEREOF
No full textThe present invention relates to heterocyclic nitrogen compounds, use thereof as a
medicament and pharmaceutical compositions thereof. Furthermore, the invention provides
combinations of compounds of general formula (I) with therapeutic agents, such as
correctors, potentiators and amplifiers of dysfunctional proteins
Knocking-down mGluR1 and mGluR5 in the SOD1/G93A mouse model of amyotrophic lateral sclerosis ameliorates survival and disease progression
No full textKnocking-down mGluR1 and mGluR5 in the SOD1/G93A mouse model of amyotrophic lateral sclerosis ameliorates survival and disease progression
No full textGroup I metabotropic glutamate receptors in ALS: knocking-down mGlu1 receptors ameliorates survival and disease progression in SOD1/G93A mice.
No full textReducing the expression of mGlu1 and mGlu5 receptors ameliorates survival and disease progression in SOD1G93A mice
No full textPartial deletion of mGluR1 receptors prolongs life span and ameliorates motor skills and biochemical and cellular parameters in a mouse model of experimental ALS
No full textCompensatory Molecular and Functional Mechanisms in Nervous System of the Grm1crv4 Mouse Lacking the mGlu1 Receptor: A Model for Motor Coordination Deficits.
No full textPhenotypic Characterization of Grm1crv4 Mice Reveals a Functional Role for the Type 1 Metabotropic Glutamate Receptor in the Skeleton
No full text
Compensatory molecular and functional mechanisms in neurons of the Grm1crv4 mouse, a murine model for ataxia lacking the mGlu1 receptor.
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