1,721,375 research outputs found

    Prediction of Response in Head and Neck Tumor: Focus on Main Hot Topics in Research

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    Radiation therapy is a cornerstone in the treatment of head and neck cancer patients; actually, their management is based on clinical and radiological staging with all patients at the same stage treated in the same way. Recently the increasing knowledge in molecular characterization of head and neck cancer opens the way for a more tailored treatment. Patient outcomes could be improved by a personalized radiotherapy beyond technological and anatomical precision. Several tumor markers are under evaluation to understand their possible prognostic or predictive value. In this paper we discuss those markers specific for evaluate response to radiation therapy in head and neck cancer for a shift toward a biological personalization of radiotherapy

    Advances in Lung Cancer Imaging and Therapy

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    This series of eight papers (five original articles, two reviews and one meta-analysis) is presented by international leaders covering various aspects of lung cancer management, starting with diagnostic imaging and analyzing the novel perspectives of therapy [...

    Case 3: Alzheimer’s Disease— Behavioral Variant

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    Alzheimer’s disease (AD) is a heterogeneous illness including “atypical” clinical presentations dominated by visual, aphasic, “frontal” (behavioral), or apraxic symptoms. Initial description of atypical phenotypes of AD was based on clinicopathologic studies, but there is a growing body of evidence coming from in vivo molecular biomarkers describing the topography of neurodegeneration or amyloid and tau pathology. In frontal presentation the severity of behavioral symptoms is lower than in behavioral Frontotemporal dementia (bvFTD), but cognitive impairment might be more evident, often showing similar memory deficit as in typical AD and worse executive functioning than patients with either bvFTD or typical AD
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