1,720,992 research outputs found
A Stereoselective Approach to both 3,4-trans-Disubstituted Pyrrolidin-2-ones and Pyrrolidines. A Convenient Synthesis of (3R,4R)-4-Benzyl-3-pyrrolidinecarboxylic Acid
No full textCyclisation of (R)- and (S)-N-allyl-N-(1-phenylethyl) methoxycarbonylacetamide mediated by Mn(III): Preparation and structural assignment of 3-aza-2-oxobicyclo[3.1.0]hexanes
No full textMetal-assisted aldol condensation of chiral 6-methyl perihydropyrimidin-4-ones
No full textThe synthesis of 6-methyl perihydropyrimidin-4-ones (1′S,6R)-3a and (1′S,6S)-3b is reported starting from rac-3-aminobutanoic acid. The aldol condensation of various metal enolates of 3a and 3b with benzaldehyde and acetaldehyde is reported. All reactions afford complete facial diastereoselectivity and good simple diastereoselectivity, depending on the nature of the enolate and of the aldehyde. The reaction yields are generally good and the aldols have been characterized by means of 1H NMR spectroscopy and NOEDIFF experiments. © 1993
Stereoselective iodocyclisation of 3-acylamino-3-aryl-2-methylenealkanoates: synthesis of analogs of N-benzoyl-syn-phenylisoserine
No full textA convenient approach to racemic analogues of N-benzoyl-syn-phenylisoserine was realized via the stereoselective iodocyclization of amides obtained from Baylis-Hillman adducts
Stereoselective iodocyclisation of 3-acylamino-2-methylene alkanoates: a computational insight
No full textNeutral liposomes containing crown ether-lipids as potential DNA vectors
No full textThree crown ether derivatives, 1,2-O-dioleoyl-3-O-{2-[(12-crown-4)methoxy]ethyl}-sn-glycerol (12C4L),
1,2-O-dioleoyl-3-O-{2-[(15-crown-5)methoxy]ethyl}-sn-glycerol (15C5L) and 2,3-naphtho-15-crown-5 (NAP5),
have been incorporated into 1-palmitoyl-2-oleoyl-phosphatydilcholine (POPC) liposomes. The size of the crown
ether and the lipophilicmoiety of 12C4L, 15C5L andNAP5 influence the stability and the properties of the extruded
POPC liposomes determined at 25 °C in buffered aqueous solution at pH 7.4. The investigated liposomes are
zwitterionic for POPC headgroups but can be turned into cationic aggregates in the presence of divalent cations.
The capability of these systems to complex DNA has been demonstrated by SAXS experiments
Chiral gamma-lactams from a Baylis-Hillman adduct: convergent, stereoselective synthesis of a glycosidase inhibitor
No full textStereoselective approach to both 3,4-trans-disubstituted pyrrolidin-2-ones and pyrrolidines.
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