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Il consenso nell’immaginario del medico in formazione. Riflessioni scaturite dalla somministrazione di un questionario
No full textPostmortem Distribution of Sildenafil in Histological Material
No full textThis study reports results of the detection and quantitation of sildenafil (Viagra) in biological fluids and tissues and its stability in fixed tissues and formalin solutions in which the tissues were fixed. Toxicological analyses were performed on samples from a 60-year-old man who died of acute heart failure due to myocardiosclerosis. Sildenafil pills were found in his pocket. At the time of autopsy, sildenafil was found in body fluids and tissues (blood 0.04 mg/L, bile 0.99 mg/L, gastric contents 6.84 mg/L, urine 9.60 mg/L, brain 6.43 mg/kg, heart 6.10 mg/kg, kidney 4.28 mg/kg, liver 5.46 mg/kg, lung 5.38 mg/kg, spleen 1.38 mg/kg). Tissue samples were preserved in formalin solutions for four weeks. Analyses of formalin-fixed tissues and formalin solutions in which the same tissues had been preserved allowed the detection and quantitation of sildenafil (brain 2.20 mg/kg, formalin from brain 4.01 mg/L; heart 1.46 mg/kg, formalin from heart 4.41 mg/L; kidney 0.98 mg/kg, formalin from kidney 3.19 mg/L; liver 2.19 mg/kg, formalin from liver 3.21 mg/L; lung 1.02 mg/kg, formalin from lung 4.18 mg/L; spleen 0.28 mg/kg, formalin from spleen 0.94 mg/L). Results indicate that sildenafil has good stability in biological specimens subjected to chemical fixation
Fatal Acute Intracranial Subdural Hematoma After Spinal Anesthesia for Cesarean Delivery: Case Report and Review of the Literature
No full textThe authors report on the autopsy case of a 40-year-old primigravida without either coagulation disorders or anticoagulant/antiplatelet therapy, who developed a fatal intracranial subdural hematoma after spinal anesthesia (SA) for elective cesarean delivery for tocophobia.Intracranial subdural hematoma is the most dreaded complication of SA and is often misdiagnosed with postdural puncture headache.In this article, the authors discuss pathophysiological mechanisms and risk factors for the development of an intracranial subdural hematoma after SA and review the pertinent literature
Ricerca e dosaggio delle sostanze d'abuso nelle unghie: un'alternativa all'analisi dei capelli?
No full textAlcol e sicurezza sul lavoro. Alcune considerazioni medico-legali e tossicologiche sui contenuti dell'articolo 15 della legge 30 marzo 2001 n. 125
No full textRetroperitoneal hemorrhage caused by trephine biopsy
No full textThe bone marrow biopsy is usually a safe procedure; however, it can occasionally present important complications. These complications are not always immediately evident or quickly diagnosed and may include pain at the biopsy site, trauma to neighboring structures, vascular injuries, infection, transient pressure neuropathies, pneumoretroperitoneum, and hemorrhage. Several risk factors are recognized, including thrombocytopenia, concurrent use of anticoagulants, and the presence of an underlying myeloproliferative disorder. While several reports of adverse events have been published, only 2 deaths attributable to this procedure have been reported. We present 2 cases of fatal hemorrhage after bone marrow biopsy
Detection and quantitation of drugs of abuse in toenails: an alternative to hair analysis?
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