1,721,056 research outputs found
Identification of a Possible Endocannabinoid-Mediated Mechanism of Action of Cetylated Fatty Acids
No full textSome musculoskeletal disorders, including osteoarthritis; arthrosis; post-traumatic injuries; and other inflammatory tendon, joint and muscular afflictions, still represent unmet medical needs. Cetylated fatty acids (CFAs) are key components of widely distributed over-the-counter products, especially for topical use, which are intended to reduce symptoms associated with these conditions. Nevertheless, the mechanism of action of CFAs’ analgesic and anti-inflammatory properties has not yet been clearly established. Endocannabinoids, such as 2-arachidonoylglycerol (2-AG) and anandamide (AEA), are known to produce analgesic and anti-inflammatory effects. These compounds undergo physiological inactivation operated by several enzymes, including monoacylglycerol lipase (MAGL). We herein demonstrate for the first time that the therapeutic effects of CFAs may be attributable, at least in part, to their MAGL inhibition activities, which induce a local increase in analgesic/anti-inflammatory endocannabinoids in close proximity to the site of administration. These findings pave the way for the development of new potent local analgesic agents, whose action is based on an indirect cannabinoid effect
FE Analysis of Low Density Hemp/Epoxy Composites Produced by a New Continuous Process
No full textThis paper aims to present a new grid composite structure obtained by stacking hemp fabric layers impregnated by resin using a new continuous process. Both the process feasibility and the mechanical properties of the obtained specimens were investigated in terms of tensile and flexural response. In addition, the effect of the superimposition error of the layers, that can affect the density and the mechanical properties of the produced bio-composites, was studied both experimentally and numerically by finite element models (FEM). The results showed that the process is able to produce low density composites possessing interesting specific mechanical properties with a good level of repeatability
Employment of the fuzzy logic modelling in the quenching of steel rods for reinforced concrete after hot rolling
No full textUdine, Ital
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