1,721,019 research outputs found
Adenosine in sperm physiology
No full textIt has long been known that ATP and cAMP are deeply involved in sperm function whereas the role of adenosine and adenosine receptors is still far from being totally construed. The presence of adenosine in male reproductive tract and adenosine receptors on spermatozoa is strongly suggestive of a functional role of these receptors in sperm physiology and function. Spermatozoa are highly differentiated cells with fertility as the only goal. This paper, by an extensive review of the literature, outlines our current understanding of the role and effects of adenosine and adenosine receptors in spermatogenesis and in the acquisition of sperm fertilizing capacity which occurs in the femal genital tract, where the motile sperm fertilize an egg to form a zygote
Cyclic dipeptides: from bugs to brain.
No full textCyclic dipeptides (CDPs) are a group of hormone-like molecules that are evolutionarily conserved from bacteria to humans. In bacteria, CDPs are used in quorum sensing (QS) to communicate information about population size and to regulate a behavioural switch from symbiosis with their host to virulence. In mammals, CDPs have been shown to act on glial cells (macrophage-like cells) to control a conceptually homologous behavioural switch between homeostatic and inflammatory modes, with implications for the control of neurodegenerative disease. Here we argue that, because of their capacity to regulate inflammation via glial cells and induce a protective response in neuronal cells, CDPs have potential therapeutic utility in an array of inflammatory diseases
Isolation of the IGF-I protein complex from rabbit seminal plasma: effects on sperm mobility and viability
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Interaction of L-alpha-methyl-alpha-hydrazino-3,4 dihydroxyphenylpropionic acid with dopa-decarboxylase from pig kidney.
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Interaction of N-(DL-seryl)N'-(2,3,4-trihydroxybenzyl)-hydrazine with L-dopa decarboxylase from pig kidney.
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