1,721,110 research outputs found
HPLC and MS analysis for the identification and characterisation of peptides presented in the context of the non-classical human leukocytes antigen (HLA) class I molecule HLA-E.
No full textTriptycene Derivatives: From Their Synthesis to Their Unique Properties
Full text linkSince the first preparation of triptycene, great progress has been made with respect to its synthesis and the understanding of its properties. Interest in triptycene-based systems is intense; in recent years, advances in the synthetic methodology and properties of new triptycenes have been reported by researchers from various fields of science. Here, an account of these new developments is given and placed in reference to earlier pivotal works that underpin the field. First, we discuss new approaches to the synthesis of new triptycenes. Progress in the regioselective synthesis of sterically demanding systems is discussed. The application of triptycenes in catalysis is also presented. Next, progress in the understanding of the relations between triptycene structures and their properties is discussed. The unique properties of triptycenes in the liquid and solid states are elaborated. Unique interactions, which involve triptycene molecular scaffolds, are presented. Molecular interactions within a triptycene unit, as well as between triptycenes or triptycenes and other molecules, are also evaluated. In particular, the summary of the synthesis and useful features will be helpful to researchers who are using triptycenes as building blocks in the chemical and materials sciences.National Science Centre, Poland (SONATA No. 2017/26/D/ST5/00361
How to Discriminate Between Leucine and Isoleucine by Low Energy ESI-TRAP MSn
No full textIn peptide sequencing experiments involving a single step tandem mass acquisition, leucine and isoleucine are indistinguishable because both are characterized by a 113 Da mass difference from the other peptide fragments in the MS2 spectrum. In this work, we propose a new method to distinguish between these two amino acids in consecutive MSn experiments, exploiting a gas-phase fragmentation of isoleucine that leads to a diagnostic 69 Da ion. We used this method to assess the Leu/Ile residues of several synthetic peptides. The procedure was then tested on a tryptic digest of myoglobin, assigning the correct amino acid in the majority of the peptides. This work was performed with an old and low-resolution instrument, thus demonstrating that our method is suitable for a wide number of ion trap mass spectrometers, not necessarily expensive or up-to-date
Simple synthesis of P1P2-Diadenosine 5'-pyrophosphate
No full textPyrophosphate-linked coenzymes play essential roles in several biochemical systems. Symmetrical diadenosine-5'-pyrophosphate (Ap2A) has been synthesized from adenosine-5'-phosphate in virtually quantitative yield. The simple procedure is carried out in anhydrous pyridine using adenosine phosphoromorpholidate and adenosine monophosphate bis-(tri-n-butylammonium salt) as coupling reagents
A new homodimer of aciclovir as a prodrug with increased solubility and antiviral activity
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Synthesis and characterization of a specific peptide nuclei acid that inhibits expression of inducible NO synthase
No full textOptimised solid phase synthesis of a cystine-linked peptide-PNA chimera
No full textA solid phase synthesis method for a cystine-linked peptide-PNA chimera starting from different modified protectedcystine monomers was developed. This strategy dramatically improved the final yield and the specificity of disulphide bondformation in this kind of oligomers, which are traditionally obtained by liquid phase coupling via oxidation of the two terminalcysteines
A planar support having an ultraflat surface and a device for detecting antigens comprising said planar support
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