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Oral disposition kinetics of ofloxacin in patients with compensated liver cirrhosis.
No full textThe disposition kinetics of ofloxacin, a quinolone antibacterial agent excreted essentially unmodified by the kidney, was studied after single oral administration in 8 patients with compensated liver cirrhosis and in 8 control subjects. Mean elimination half-life and apparent volume of distribution were significantly increased in the cirrhotic group (7.6 vs. 4.9 h and 1.6 vs. 1.2 liters kg-1, respectively). A reduction in the renal clearance of ofloxacin was also observed in the cirrhotic patients, in spite of an apparently normal renal function. These observations indicate that also the pharmacokinetics of unmetabolized drugs may be altered in compensated liver cirrhosis. The serum concentration-time profiles of nearly all subjects exhibited a secondary peak 4-6 h after dosing. This double-peak behavior was interpreted as either enterohepatic circulation or biphasic gastric emptying of ofloxacin
Serum antibacterial activity following oral clarithromycin in patients with liver cirrhosis.
No full text
[Experimental and clinical pharmacokinetics of amrinone].
No full textArticolo sperimentale nell'uomo circa l'amrinone, in un tempo nel quale tale farmaco era considerato avveniristico. Ampia descrizione delle sue proprietà farmacocinetiche in campo umano, con messa a punto di un metodo per la determinazione delle concentrazioni
The behaviour of miocamycin kinetics in cirrhotic patients after single and repeated oral administration.
No full textPharmacokinetics of miocamycin in patients with liver cirrhosis.
No full textThe pharmacokinetics of miocamycin, a new macrolide antibiotic, was studied in 6 healthy controls and 6 patients with compensated liver cirrhosis. The results indicate that in chronic liver disease the kinetics of the drug is altered. Therefore, a dosage adjustment of miocamycin is recommended when dealing with these patients
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