1,721,318 research outputs found

    Long-term pan evaporation observations: a precious resource to understand the water cycle trend

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    Acceleration of the global water cycle over recent decades remains uncertain because of the high inter-annual variability of its components. Observations of pan evaporation (Epan), a proxy of potential evapotranspiration (ETp), may help to identify trends in the water cycle over long periods. The complementary relationship (CR) states that ETp and actual evapotranspiration (ETa) depend on each other in a complementary manner, through land-atmosphere feedbacks in water-limited environments. Using a long-term series of Epan observations in Australia, we estimated monthly ETa by the CR and compared our estimates with ETa measured at eddy covariance Fluxnet stations. The results confirm that our approach, entirely data-driven, can reliably estimate ETa only in water-limited conditions. Furthermore, our analysis indicated that ETa did not show any significant trend in the last 30 years, while short-term analysis may indicate a rapid climate change that is not perceived in a long-term perspective.Editor Z.W. Kundzewicz; Associate editor D. GertenCitation Lugato, E., Alberti, G., Gioli. B., Kaplan, J.O., Peressotti, A., and Miglietta, F., 2013. Long-term pan evaporation observations as a resource to understand the water cycle trend: case studies from Australia. Hydrological Sciences Journal, 58 (6), 1287-1296. © 2013 IAHS Press

    FINANZA ISLAMICA PER LE SOCIETA' DI GESTIONE

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    La finanza basata sul corano, e dunque gli investimenti “islamici” incorporano nella selezione i criteri di liceità religiosa. Tuttavia, l’idea che criteri religiosi e morali possano influenzare la selezione e la successiva scelta degli investimenti di portafoglio non è nuova, né esclusiva dell’economia islamica. Nel capitolo di affrontano i temi relativi alla gestione dei fondi in ottica islamic

    NOZIONI INTRODUTTIVE DI FINANZA ISLAMICA

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    Per comprendere l’Islam, religione monoteistica nata nel VI° secolo, e le regole cui oltre un miliardo di fedeli si attengono nei loro comportamenti sociali, religiosi ed economici, viene proposta al lettore la disamina di alcuni punti fondamentali per delineare le basi della religione e della economia islamica

    Immune Infiltrates in Breast Cancer: Recent Updates and Clinical Implications

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    In recent decades, the increasing interest in the field of immunotherapy has fostered an intense investigation of the breast cancer (BC) immune microenvironment. In this context, tumor-infiltrating lymphocytes (TILs) have emerged as a clinically relevant and highly reproducible biomarker capable of affecting BC prognosis and response to treatment. Indeed, the evaluation of TILs on primary tumors proved to be strongly prognostic in triple-negative (TN) BC patients treated with either adjuvant or neoadjuvant chemotherapy, as well as in early TNBC patients not receiving any systemic treatment, thus gaining level-1b evidence in this setting. In addition, a strong relationship between TILs and pathologic complete response after neoadjuvant chemotherapy has been reported in all BC subtypes and the prognostic role of higher TILs in early HER2-positive breast cancer patients has also been demonstrated. The interest in BC immune infiltrates has been further fueled by the introduction of the first immune checkpoint inhibitors in the treatment armamentarium of advanced TNBC in patients with PD-L1-positive status by FDA-approved assays. However, despite these advances, a biomarker capable of reliably and exhaustively predicting immunotherapy benefit in BC is still lacking, highlighting the imperative need to further deepen this issue. Finally, more comprehensive evaluation of immune infiltrates integrating both the quantity and quality of tumor-infiltrating immune cells and incorporation of TILs in composite scores encompassing other clinically or biologically relevant biomarkers, as well as the adoption of software-based and/or machine learning platforms for a more comprehensive characterization of BC immune infiltrates, are emerging as promising strategies potentially capable of optimizing patient selection and stratification in the research field. In the present review, we summarize available evidence and recent updates on immune infiltrates in BC, focusing on current clinical applications, potential clinical implications and major unresolved issues

    Interconnectedness between Islamic and conventional banks: a multilayer network view

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    Purpose This study aims to examine information (stock return, volatility and extreme risk) spillovers and interconnectedness within dual-banking systems. Design/methodology/approach Using multilayer information spillover networks, this paper conduct a deep analysis of contagion dynamics among 24 Islamic and 46 conventional banks from 2006 to 2022. Findings The findings show the network’s rapid response to financial shocks. Through cross-sector analysis, this paper identify information spillovers between and within Islamic and conventional banking systems. Furthermore, this research illustrates distinct roles played by Islamic and conventional banks within the multilayer network structure, contingent upon the nature of the financial shock. Practical implications Understanding the differential roles of Islamic and conventional banks in information transmission can aid policymakers and financial institutions in devising more effective risk management strategies, thereby enhancing financial stability within dual-banking systems. Originality/value This study contributes to the literature by emphasizing the necessity of examining contagion mechanisms beyond traditional single-layer network structures, shedding light on the shadow dynamics of information transmission in dual-banking systems
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