53,218 research outputs found
Clinical Manifestations of gallstone disease: evidence from the Multicenter Italian study on Cholelithiasis (MICOL)
No full textAbstract: Despite the many efforts to delineate the clinical manifestations of gallbladder disease, the precise symptom complex associated with gallstones is still a matter of debate, and even the existence of gallstone-specific symptoms has been questioned. We carried out a large population-based cross-sectional study (MICOL) to identify symptoms significantly related to gallstones, Fourteen centers throughout Italy enrolled 29,504 subjects aged 30 to 69 years. All subjects were administered an ultrasonographic examination of the upper abdomen and a preceded questionnaire. All subjects were divided into 4 groups: 25,374 (86.0%) gallstone-free subjects (GF), 1,832 (6.2%) patients with gallstones not previously diagnosed (GNPD), 638 (2.2%) patients with gallstones previously diagnosed (GPD), 1,660 (5.6%) patients with a history of cholecystectomy for gallstones (CC). In logistic regression analysis, pain at epigastrium and, even more, pain at right hypocondrium were significantly associated with gallstones, For pain at right hypocondrium, this association progressively increased from GNPD (OR = 1.60, 95% CI = 0.97-2.65) to GPD (OR = 8.77, 95% CI = 5.27-14.61) to CC (OR = 59.40, 95% CI = 43.87-80.42). Absence of heartburn combined with right hypocondrium or epigastrium pain and intolerance to fried or fatty food were also significantly related to gallstones. We also found some pain characteristics significantly associated with gallstones, i.e,, pain radiated to the right shoulder, forcing the patient to rest, occurring soon after meals or unrelated to meals, not relieved by bowel movements, and frequently accompanied by gallstone-related morbidities. We developed a probability tree reporting the cumulative probability of having gallstones for each combination of those symptoms and characteristics of pain significantly associated with gallstones, In conclusion, we have identified symptoms and signs significantly associated with gallstones. We have shown that there is an increase in frequency and severity of these symptoms and signs across the different stages of gallstone disease. We have proposed a complex of symptoms and signs significantly associated with gallstones that might help physicians in clinical decision making
Clinical manifestations of gallstone disease: evidence from the multicenter Italian study on cholelithiasis (MICOL)
No full textAIM: To evaluate gallstone incidence and risk factors in a large population-based study. METHODS: Gallstone incidence and risk factors, were evaluated by structured questionnaire and physical examination, respectively, in 9611 of 11 109 (86.5%) subjects who were gallstone-free at the cross-sectional study. RESULTS: Six centers throughout Italy enrolled 9611 subjects (5477 males, 4134 females, aged 30-79 years), 9517 of whom were included into analysis: 424 subjects (4.4%) had gallstones and 61 (0.6%) had been cholecystectomized yielding a cumulative incidence of 0.67% per year (0.66% in males, 0.81% in females). Increasing age, a high body mass index (BMI), a history of diabetes, peptic ulcer and angina, and low cholesterol and high triglyceride levels were identified as risk factors in men while, in females, the only risk factors were increasing age and a high BMI. Increasing age and pain in the right hypocondrium in men and increasing age in females were identified as predictors of gallstones. Pain in the epigastrium/right hypocondrium was the only symptom related to gallstones; furthermore, some characteristics of pain (forcing to rest, not relieved by bowel movements) were significantly associated with gallstones. No correlation was found between gallstone characteristics and clinical manifestations, while increasing age in men and increasing age and BMI in females were predictors of pain. CONCLUSION: Increasing age and BMI represent true risk factors for gallstone disease (GD); pain in the right hypocondrium and/or epigastrium is confirmed as the only symptom related to gallstones
Project Retrosight. Understanding the returns from cardiovascular and stroke research: Case Studies
No full textCopyright @ 2011 RAND Europe. All rights reserved. The full text article is available via the link below.This project explores the impacts arising from cardiovascular and stroke research funded 15-20 years ago and attempts to draw out aspects of the research, researcher or environment that are associated with high or low impact. The project is a case study-based review of 29 cardiovascular and stroke research grants, funded in Australia, Canada and UK between 1989 and 1993. The case studies focused on the individual grants but considered the development of the investigators and ideas involved in the research projects from initiation to the present day. Grants were selected through a stratified random selection approach that aimed to include both high- and low-impact grants. The key messages are as follows: 1) The cases reveal that a large and diverse range of impacts arose from the 29 grants studied. 2) There are variations between the impacts derived from basic biomedical and clinical research. 3) There is no correlation between knowledge production and wider impacts 4) The majority of economic impacts identified come from a minority of projects. 5) We identified factors that appear to be associated with high and low impact. This report presents the key observations of the study and an overview of the methods involved. It has been written for funders of biomedical and health research and health services, health researchers, and policy makers in those fields. It will also be of interest to those involved in research and impact evaluation.This study was initiated with internal funding from RAND Europe and HERG, with continuing funding from the UK National Institute for Health Research, the Canadian Institutes of Health Research, the Heart and Stroke Foundation of Canada and the National Heart Foundation of Australia. The UK Stroke Association and the British Heart Foundation provided support in kind through access to their archives
Unlocking the mysteries of the past: Searching for clues in medieval manuscripts
No full textThis project looks at the reproduction of one mid-12th-century Roman text by analyzing sixteen versions of it that still exist, copied from c. 1160 through c. 1325. The author was Nicolaus Maniacutius, a cleric at St. John Lateran Basilica in Rome. That original copy is lost, but versions quickly appeared in monasteries and cathedrals in Italy, Germany, France, and England. Somehow, through networks of communication and travel, reproductions were made and collected by prominent monasteries and churches, and by the Guildhall, a secular institution in the City of London
Integrated Small Dense Low-density Lipoprotein Profile in Cardiovascular Disease and Cancer: A longitudinal study
No full textBackground/Aim: Low-density lipoproteins (LDL) are a heterogeneous class of particles that differ in size and density from each other. Small dense LDL (sdLDL) particles are considered more atherogenic than larger particles. The aim of the study was to evaluate serum levels of sdLDL in patients who died from cardiovascular diseases (CVD) or cancer in a cohort of patients followed up in the De Bellis Research Hospital for 20 years. Patients and Methods: A total of 75 participants who died of cancer and 87 who died of CVD were enrolled and they were matched for age and sex with 135 healthy controls, i.e. without CVD or cancer and are still alive. Results: Patients who died from cancer had the highest value of LDL IV subfraction (0.25±1.16), followed by those who died from CVD (0.17±0.96). Conclusion: The integrated profile of sdLDL between CVD and cancer suggests that therapeutic modulation of sdLDL may be associated with a risk reduction for these diseases. © 2019 International Institute of Anticancer Research. All rights reserved
Dissemination of research: Author bibliometrics (EMRSG project)
No full textThis unit is part of a collaboratively produced set of 5 units, created using the Xerte toolkit, aimed at academic researchers to enable them to enhance the dissemination of their research outputs. Through a mixture of text, videos and reflective activities, 'Author bibliometrics' allows participants to undertstand the different metrics available; recognise the advantages and disadvantages of using bibliometric data; reflect on the uses of bibliometric data; recognise some of the available sources to search for this type of data.
Group interaction as the crucible of social identity formation : a glimpse at the foundations of social identities for collective action
No full textThis research was supported by the Australian Research Council (DE120101029 to the first author and DP0770731 to the second author).Many of the world’s biggest problems are being tackled through the formation of new groups yet very little research has directly observed the processes by which new groups form to respond to social problems. The current paper draws on seminal research by Lewin (1947) to advance a perspective as to how such identities form through processes of small group interaction. Multi-level structural equation modelling involving 58 small group discussions (with N = 234) demonstrates that focused group discussion can boost the commitment to take collective action, beliefs in the efficacy of that action and members’ social identification with other supporters of the cause. The results are consistent with the new commitment to action flowing from emergent social identities.Peer reviewe
Medieval Pottery Research Group Bibliography
No full textThe MPRG Bibliography is an on-line national bibliography of published reports, books and articles on post-Roman ceramics. The on-line, searchable version of this bibliography as released by the ADS in 2010 contains nearly 13000 entries covering the whole of the British Isles, including the Republic of Ireland, the Isle of Man and the Channel Islands. Searches into the bibliography can be carried out on a number of fields including author, title, publication date, site type, period, county and ceramic category
Mapping 50 Years of Small Group Research Through Small Group Research
No full textThis is the Accepted Manuscript version of Emich, K. J., Kumar, S., Lu, L., Norder, K., & Pandey, N. (2020). Mapping 50 Years of Small Group Research Through Small Group Research. Small Group Research, 51(6), 659–699. https://doi.org/10.1177/1046496420934541. This article was originally published in Small Group Research. The version of record is available at: https://doi.org/10.1177/1046496420934541. © The Author(s) 2020.At its 50-year milestone, we assess the Small Group Research (SGR) corpus to reflect on the development of group research over the past half century. To do this, we examine the evolution of the corpus’s context and content. We examine its context by assessing its impact, which journals it communicates with, and the internationality of its authors. We examine its content—the topics discussed in its articles—using keyword clustering and co-occurrence network analysis. We identify 10 research communities and track their relationships over the four editorial periods associated with the SGR corpus (lagged 2 years for influence): 1970–1981, 1982–1991, 1992–2010, and 2011–2019. Our analyses indicate that the global and local study of group dynamics has fluctuated over time and that phenomenologically based topics connect theoretical topics and stimulate theoretical development. We also provide three criteria to identify communities and topics of group research most likely to benefit from future integration.The author(s) received no financial support for the research, authorship, and/or publication of this article
Research methodology of grazing
No full textThroughout Europe, grass is the main feed for dairy cattle. This report presents the main results of the first meeting of the European Grassland Federation (EGF) Working Group Grazing in Kiel on 29 August 2010. The theme of the meeting was "Research methodology of grazing". There were three sessions: - setting the scene; - modelling of grazing; and - field measurements
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