1,720,967 research outputs found
Cytomegalovirus infection of endocrine system in a patient with diffuse large B-cell lymphoma. Report of a case
No full textCytomegalovirus (CMV) is an opportunistic pathogen causing different diseases in immunocompromised patients and leading to death in a high percentage of cases.
CMV infection is also relatively frequent among patients with hematological malignancies, especially when treated with immunosuppressive agents. We describe the clinical history of a patientwith stage IV diffuse large B-cell lymphoma (DLBCL) treated with eight courses of R-CHOP every two weeks, who presented clinical remission of the disease at the end of therapy. However, two months later he developed neurological symptoms due to cerebellar involvement and a subcutaneous dorsal lymphomatous infiltration. He had a partial response after chemotherapy and brain radiotherapy, but his clinical course was complicated by fever and hypotension. Although the fever resolved with broad-spectrum antibiotics, he presented progressive
endocrine failure and died three weeks later. Autopsy confirmed disseminated multiorgan involvement by DLBCL associated with an unexpected CMV infection of the lungs and several endocrine organs including the pituitary gland, pancreatic islets and adrenals, a clinical association not previously reported in the English literatur
Adenohypophyseal differentiation in ovarian mature cystic teratomas and in ovarian carcinoids
No full textAspetti clinico-patologici dei teratomi maturi cistici dell’ovaio e caratterizzazione delle componenti endocrine
No full textFrequency and chacterization of anterior pituitary component in ovarian mature cystic teratomas.
No full textDynamic Identification of the Collapse Mechanisms of a Masonry Arch
No full textThe preservation, the safeguard and the
valorization of the existing architectural heritage requires the
development of theoretical and experimental approaches that
can effectively identify any damage of the structures that could
lead to their collapse. In the case of masonry constructions, the
methodology becomes complex both due to the uncertainties
deriving from the mechanical behavior of the masonry material,
and due to the necessity to use contactless experimental
approaches, which do not lead to the damage of the structure
and can also be performed during the service life phase. In this
article, we propose a damage identification method for masonry
arches and vaults, based on the analysis of the dynamic tests
results. In particular, our approach is able to identify the
collapse mechanism of masonry curved structures in terms of
position of hinges and depths of cracks. The case study consists
of a clay-brick masonry arch subjected to an eccentric load on
extrados. The experimental values of frequencies were used to
calibrate a numerical model of the undamaged arch. A
comparison between numerical and experimental frequencies
values related to damaged and undamaged configuration was
allowed to develop an effective approach to identify the collapse
mechanism of arch
Frequency and characterization of anterior pituitary component in ovarian mature cystic teratomas
No full textCarcinoma renale a piccole cellule. Studio morfologico, immunoistochimico, ultrastrutturale e citogenetica
No full textPrimary small cell neuroendocrine carcinoma of the kidney: morphological, immunohistochemical, ultrastructural, and cytogenetic study of a case and review of the literature
No full textPoorly differentiated neuroendocrine carcinomas (PDNECs) of the kidney are extremely rare high-grade cancers accounting for only 42 cases reported in the literature. In this paper, we describe the morphological, immunohistochemical, ultrastructural, and for the first time, cytogenetic features of a renal PDNEC. In addition, we have reviewed the literature and compared the published clinicopathological data with our morphological and genetic results. The tumor arose within the kidney parenchyma and showed the typical histological features of a pure small cell PDNEC. Fluorescence in situ hybridization study demonstrated a complex chromosomal assessment indicative of a high degree of chromosome instability with gain of multiple chromosomes, loss of p53, and amplification of myc gene. These results suggest that renal PDNEC has a different genetic background to renal clear cell carcinoma, mainly characterized by the loss of the short arm of chromosome 3. Conversely, genetic alterations seem to resemble those of type 2 papillary renal cell carcinoma. The review of the literature demonstrated that PDNECs are associated with poor prognosis and that parenchymal tumors show some differences from those arising in the pelvis, in that parenchymal tumors are purely neuroendocrine while pelvic tumors are mostly mixed neuroendocrine-exocrine neoplasms
CLINICO-PATHOLOGICAL PROFILE OF ESTROGEN AND PROGESTERONE NEGATIVE BREAST CARCINOMAS WITH BASAL OR LUMINAL MARKERS EXPRESSION
No full text
- …
