35 research outputs found
Author Correction: Dynamics of RIF1 SUMOylation is regulated by PIAS4 in the maintenance of Genomic Stability (vol 7, 2017)
No full text10.1038/s41598-018-23385-4SCIENTIFIC REPORTS8
Genetic Polymorphism of Inosine Triphosphate Pyrophosphatase Is a Determinant of Mercaptopurine Metabolism and Toxicity During Treatment for Acute Lymphoblastic Leukemia
No full textThe influence of genetic polymorphism in inosine triphosphate pyrophosphatase (ITPA) on thiopurine-induced adverse events has not been investigated in the context of combination chemotherapy for acute lymphoblastic leukemia (ALL). This study investigated the effects of a common ITPA variant allele (rs41320251) on mercaptopurine metabolism and toxicity during treatment of children with ALL. Significantly higher concentrations of methyl mercaptopurine nucleotides were found in patients with the nonfunctional ITPA allele. Moreover, there was a significantly higher probability of severe febrile neutropenia in patients with a variant ITPA allele among patients whose dose of mercaptopurine had been adjusted for TPMT genotype. In a cohort of patients whose mercaptopurine dose was not adjusted for TPMT phenotype, the TPMT genotype had a greater effect than the ITPA genotype. In conclusion, genetic polymorphism of ITPA is a significant determinant of mercaptopurine metabolism and of severe febrile neutropenia, after combination chemotherapy for ALL in which mercaptopurine doses are individualized on the basis of TPMT genotype
Interactive Digital Storytelling based educational games:formalise, author, play, educate and enjoy! - The edugames4all project framework
No full textIn this paper, we present an Interactive Digital Storytelling (IDS) formalisation that captures the IDS logic constraints. This was implemented in a game engine and an authoring tool was created to facilitate the development of IDS based games. We created several IDS based games using the proposed engine and authoring tool. They were used as case studies in this research. We also present some of the challenges we encountered once the games were implemented and how we addressed them
Use of the Internet to facilitate electronic data interchange between small and large enterprises
No full textThis thesis was scanned from the print manuscript for digital preservation and is copyright the author.
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Author Correction: Dynamics of RIF1 SUMOylation is regulated by PIAS4 in the maintenance of Genomic Stability
No full textA correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.</jats:p
Numerical analysis of fluid flow and heat transfer during melting inside a cylindrical container for thermal energy storage system
No full textRating a Researcher’s Cumulative Scholarly Output Based on Their Sequence Numbers in Multi-Authored Publications
No full textAs the academic world yields an ever-increasing research output in terms of journal papers, conference proceedings, and books, the rating of published works and authors becomes imperative. All the big citation databases and search engines are currently using cumulative output indices, such as h-index, i10-index, and g-index, which do not consider the number of co-authors or the researcher’s sequence number in the authors list of a publication. In this context, the article presents a novel computational approach for evaluating a researcher’s scholarly output by taking into account the total number of co-authors, the sequence number of the researcher in the authors list, and the number of citations received per year by an article. Arithmetic progression is applied to quantify the credit for each co-author of a publication. The respective credits of a researcher are then accumulated for all their publications to obtain the rating. The method yields a truer value of the researcher’s impact in terms of their scholarly activities. A global implementation of the metric presented in this work will curb the unethical practice of including the names of non-contributing researchers in the authors list and expecting reciprocity in return
Developmental Impacts of Remittances on Migrant-Sending Households: Micro-Level Evidence from Punjab, Pakistan
No full textThis article analyzes the overall and type of developmental impacts of remittances for migrant-sending households (HHs) in districts of Punjab, Pakistan. For this purpose, an HH-based human development index is constructed based on the dimensions of education, health and housing, with a view to enrich insights into interactions between remittances and HH development. Using high-quality data from a HH micro-survey for Punjab, the study finds that most migrant-sending HHs are better off than the HHs without this stream of income. More importantly, migrant HHs have significantly higher development in terms of housing in most districts of Punjab relative to non-migrant HHs. Thus, the government would need policy interventions focusing on housing to address inequalities in human development at the district-HH level, and subsequently balance its current focus on the provision of education and health. © The Author(s) 2019
Internet-Enabled User Interfaces for Distance Learning
No full textThis chapter describes the integration of handheld computers in K-12 classrooms and its impact on digital literacy. Following a brief description of this new technology for education, teacher stories are used to illustrate what types of educational activities are possible above and beyond what is possible with available technology, what pedagogical changes need to be made to effectively integrate handheld technology in K-12 classrooms, how handheld devices can be adapted to harness their full potential as ubiquitous devices for teaching and learning, and how digital literacy skills influence and are being influenced by this technology. The ultimate goal of the author is to show that handheld computers have the potential to have a tremendous impact on teaching and learning, given the right context.</jats:p
Investigation of Structural and Thermal Evolution in Novel Layered Perovskite NdSrMn2O5+δ via Neutron Powder Diffraction and Thermogravimetric Analysis
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