1,721,091 research outputs found
Influence of the aspect ratio of an additive manufacturing component on the surface roughness during cutting with wire EDM
Full text linkAluminum alloy AlSi10Mg is among the most used alloys in powder bed additive technologies with laser source (PBF-LB/M) to make light components in sectors such as aerospace and automotive. These components can have complex shapes and are made in some extrusions directly on the construction platform in order to remove them by wire electrical discharge machining (WEDM) and obtain a surface roughness already suitable to be able to assemble the parts with other components. This study investigated two aspects: the robustness of different instruments for profile and areal roughness measurements on AlSi10Mg parts produced by the PBF-LB/M process; and the effect of the aspect ratio of the components on the surface roughness obtained from WEDM. A better correspondence between the P- and S-parameters was found than that reported in the literature between the S- and R-parameters. Analyzing the relationship between weight and height of the AlSi10Mg components, the results showed that the heaviest and tallest component presents the least roughness (Ra = 5.05 ± 0.63 μm and Rz = 33.11 ± 4.29 μm). However, it emerged that the various areas of the piece have different roughness values (from Ra = 7.65 ± 2.85 μm and Rz = 43.07 ± 13.12 μm to Ra = 15.21 ± 7.37 μm and Rz = 68.39 ± 25.75 μm) of and this requires constant adjustment of the cutting parameters to have uniform surface roughness
The multifaceted mechanisms of nitroxyl in heart failure: inodilator or ‘only’ vasodilator?
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Rapid sexual maturity and short life span in the blue-legged frog and the rainbowfrog from the arid Isalo Massif, southern-central Madagascar.
No full textInflammatory Mechanisms in the Pathogenesis of Pulmonary Arterial Hypertension: Recent Advances
No full textInflammatory processes are increasingly recognized in the pathogenesis of the vascular remodeling that characterizes pulmonary arterial hypertension (PAH). Chronic inflammation may contribute to disease progression or serve as a biomarker of PAH severity. Furthermore, inflammatory pathways may represent possible therapeutic targets for novel PAH-specific drugs beyond the currently approved therapies targeting the endothelin, nitric oxide/cyclic GMP, and prostacyclin biological pathways. The main focus of this article is to provide recent advances in the understanding of the role of inflammatory pathways in the pathogenesis of PAH from preclinical studies and current clinical data supporting chronic inflammation in PAH patients and to discuss emerging therapeutic implications. © 2021 American Physiological Society. Compr Physiol 11:1805-1829, 2021
DETERMINAZIONE DELLA COMPONENTE AROMATICA VARIETALE QUALE MARCATORE DI PROCESSO E DI CONSERAVZIONE DEI VINI AUTOCTONI CAMPANI
No full textEffects of a nutraceutical combination on left ventricular remodeling and vasoreactivity in subjects with the metabolic syndrome
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