1,721,062 research outputs found
Perfusate Enzymes and Platelets Indicate Early Allograft Dysfunction After Transplantation of Normothermically Preserved Livers
No full textViability testing during normothermic machine perfusion requires both hepatocellular and cholangiocellular criteria
No full textKnowledge and irreversibility of cell death: “Nought may endure but mutability”
No full textBy using appropriate machine perfusion technologies, such as OrganEx, isolated intact large mammalian brain and other organs, possess the capacity for restoration of microcirculation, and molecular and cellular activity after a prolonged post-mortem interval. We might be ready to critically re-evaluate our concepts and criteria of death under the light of newly acquired knowledge
UNUSUAL CORRELATION OF LATE IGA-NEPHROPATHY RECURRENCE AND RENAL PAPILLARY CARCINOMA DEVELOPED IN A KIDNEY TRANSPLANT RECIPIENT
No full textA case of a 50-year-old Caucasian man transplanted in 1987 for an end-stage renal disease caused by an IgAN is reported. The graft was from a living donor. Immunosuppression regimen was based on cyclosporine, azathioprine and steroids. After 25 years of uneventful follow-up, the patient developed a generalized edema and was hospitalized. At blood tests, serum creatinine was 4 mg/dl and a marked proteinuria was reported (18 g/24 h). No renal masses were observed at ultrasounds. A renal biopsy was performed, showing granular deposits of IgA ( +++), IgM (++), C3 (+), kappa (+) and lambda(++) light chains in the mesangium: IgAN recurrence was diagnosed. Drug regimen was modified with the intent to treat both the IgAN recurrence and the proteinuria: however, the status of poor renal function persisted. Six months later, a new ultrasounds control was performed, showing three lesions at the level of the allograft. A CT scan confirmed the diagnosis. A renal biopsy showed of a papillary renal cell carcinoma type 1. The patient underwent the explantation of the allograft. The tumor was confirmed at pathology on the specimen. The post-operative course was uneventful, and the patient is still alive after a period of 6 months, having restarted the substitutive therapy with haemodyalisis. IgAN recurrence after transplant is common, while development of a tumor on the allograft is anecdotic: however no data exist in Literature about a contemporaneous presentation of both these pathologies
Use of elderly donors for liver transplantation: has the limit been reached?
No full textBackground & Aim: Several solutions have been proposed for the minimization of both organ shortage and prolonged waiting time for liver transplantation (LT): expansion of the donor pool using elderly donors represents a possible solution. However, it is still not fully explained if the use of "extreme" donors could cause inacceptable post-transplant adjunctive risks. The aim of the study is to evaluate the impact of donor age on post-LT patient and graft survival. Methods: A cohort of 188 LTs were stratified in four groups according to donor age (Group 1: age 70 year-aged donors should be considered with caution and only in selected cases
Hypothermic oxygenated perfusion for a steatotic liver graft
No full textDonor steatosis represents a well-known risk factor for primary non-function, early allograft dysfunction, and biliary complications after liver transplantation (LT). Recently, machine perfusion (MP) technology has been implemented in the clinical practice, with the primary intent to assess the graft quality and to optimize the organ selection process. A limited number of articles has been published specifically investigated the role of MP in steatotic livers, with few of them looking at the role of hypothermic MP
Liver viability using normothermic regional perfusion in uncontrolled donation after circulatory death deserves a multi-parametric assessment
No full textROLE OF BIOCHEMICAL- AND HISTOLOGICAL-BASED SCORES FOR THE PREDICTION OF GRAFT FAILURE AFTER LIVER TRANSPLANTATION
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