1,721,018 research outputs found
Lyell's syndrome skin lesions treated by Veloderm® [25]
No full textLyell's syndrome, also known as toxic epidermal necrolysis (TEN), is a drug-related dermatological disorder characterized by epidermal sloughing, mucous membrane involvement, fever, pain, and systemic symptoms. In TEN topical treatment minimizes heat and fluid loss, prevents infections, reduces pain, and provides a moist, clean wound environment suitable for re-epithelialization. We tested a new material (Veloderm®, BTC srl, Ancona, Italy) consisting of a natural cellulose-microfibre biofilm, the effectiveness and excellent tolerability of which has been described in the treatment of burns and superficial wounds
Widespread basal cell carcinoma of the scalp treated by dermabrasion
No full textTreatment of the basal cell carcinomas in the basal cell naevus syndrome is similar to that of other basal cell carcinomas. However, occasionally innovative approaches are required, as in this case of a 29-year-old woman with widespread superficial multifocal basal cell carcinomas of the scalp
Skin failure: A two-faced concept
No full textWhile it is well accepted that the skin is an organ of the body, the fact that it can fail as many other organs do, is not well understood and considered. Some attempts have been made to define “skin failure” with two distinct and quite different meanings, which reflect, in a way, an “inside out” vs an “outside in” pathogenetic process
The use of allograft skin for the treatment of darier disease
No full textDarier disease is an autosomal dominant skin disorder characterized by keratotic papules. After their appearance, these lesions tend to grow over time, producing large and exudative plaques that compromise the general condition of the affected patient's skin. The authors report the clinical case of a patient affected by Darier disease with superinfected de-epithelialized areas over 30% of his body. In addition to antibiotic and antifungal therapy, providers used allograft skin to cover the injured areas and stimulate their progressive re-epithelialization with complete healing after 2 months. To the authors' knowledge, this is the first clinical case of treating Darier disease with allograft skin on an extensively damaged area. The effectiveness of this treatment may lead clinicians to consider allograft skin tissue a new, alternative dressing to treat Darier disease when this pathologic condition manifests with extensive eroded skin
Quality of life impact as outcome in burns patients
No full textPurpose. Severe burns have not only physical but also psychological consequences both during and after hospitalisation. By identifying the mainly impaired areas of a patient's quality of life (QoL), specific psychological support programmes can be provided. The assessment of subjectively perceived QoL impairment can also provide an indicator of the outcome of the medical and psychological treatment. Method. This study used the Sickness Impact Profile (SIP) to investigate QoL in 30 burned patients after discharge and again three months' later. Results. At the first assessment, both the physical and psychological dimensions were significantly unpaired, although there was an improvement at the 3-month follow-up, particularly in the physical dimension. Data suggest that there are QoL areas that appear to be compromised in burn patients. Even after hospital discharge, the burn injury causes major limitations that extend well beyond the physical area and involve emotional, social and relational aspects. Nevertheless, most of the categories in the physical dimension tend to improve during follow-up and, three months after the first administration, the predominant limitations are in emotional behaviour and sleep and rest in the psychosocial dimension. The SIP score matched for depth and extent of burns show that females were in poorer health than males. At the first administration, gender-related differences were particularly marked in Ambulation (p*M5), Body Care and Movement (p=.004), Home Management (p=M3), Mobility (P=Ml), Physical Dimension (p=.0O4) and the QoL general score (p=.031). Although all of these areas had improved by the time of the retest, the gender-related differences remained. The categories assessed with the Psychosocial Dimension of SlP did not correlate with tile clinical parameters of the burn, whereas those pertaining to the Physical Dimension did. Conclusion. Multidisciptinary support for burn patients appears to be necessary even many months after hospital discharge. © PI-ME, Pavia 2009
Eccrine Angiomatous Hamartoma with Atypical Localization Treated by Mohs Micrographic Surgery
No full textEccrine angiomatous hamartoma (EAH) is a rare hamartoma characterized by a benign proliferation of eccrine glands and vascular structures in the dermis. These tumors rarely regress spontaneously, so surgical excision of the involved tissue is required when pain or enlargement occurs. Here, the authors report the clinical case of a patient affected by an extremely painful EAH with the atypical localization at the last phalanx of the thumb of the right hand with involvement of nail matrix and nail bed. This report aims to emphasize the application of Mohs micrographic surgery for the treatment of painful EAH in a very difficult area at potential risk of amputation while preserving the maximum anatomical integrity and function of the damaged area. These results can pave the way for the use of Mohs micrographic surgery for very carefully selected benign neoplasms when their surgical removal is required
Painful plantar nodules: A specific manifestation of cutaneous macroglobulinosis
No full textIn December 2013, a 70-year-old man came to our service for nodules covered by a thick hyperkeratotic layer on the soles of his feet. The lesions were extremely painful to pressure, to the extent of limiting his daily activities. They had appeared about 2 years earlier and were treated as viral warts with keratolytic agents, without success. The patient's history showed that he had been followed by the hematology service for 15 years with periodic clinical evaluations and no therapy for a diagnosis of Waldenström macroglobulinemia (WM)
Preliminary observations of a new approach to tissue repair: Peripheral blood mononuclear cells in platelet-rich plasma injected into skin graft area
No full textOur purpose was accelerating the physiologic wound healing, stimulating tissue regeneration and the reparative tissue processes in resistant skin ulcers as in a case of an erosive lichen planus of the soles and after a surgical treatment as for severe Darier disease. The challenge was to establish an effective therapy to enhance tissue healing by the injection of a mixture of peripheral blood mononuclear cells (PB-MNCs) and platelet-rich plasma (PRP) into a skin autograft area. This new perioperative biotechnological approach enriches PRP with the effects of PB-MNCs. It offers a novel advanced strategy that could become an ideal biologic blood-derived therapy, whose components are entirely autologous and produced by a protocol independent by the operator
Histological observations and clinical experiences with the regenerative biological matrix "Hyalomatrix"
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