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Neuroanatomia clinica (Traduzione italiana della 25a edizione inglese "Clinical Neuroanatomy)
No full textThe regenerating muscle as an experimental model for the study of factors which affect muscle differentiation or adaptation
No full textBupivacaine-induced regeneration was studied in the rat soleus muscle in the presence or absence
of innervation, in the presence of tetrodotoxin (TTX)-induced block of nerve impulse
conduction, and/or in the presence of vinblastine-induced block of nerve axoplasmic flow.
Part of experiments were carried out on tenotomized muscles. Regenerated muscles were
analysed for myosin heavy chain (MHC) composition 14 days after bupivacaine injection. In
TTX-paralysed-regenerated muscles type 1 and type 2A MHC isoforms were not expressed.
In denervated-regenerated muscles type 1 isoform was lacking, while all fast isoforms (2A,
2B, 2X) were expressed. Tenotomy alone increased type 2A fibres, but did not modify the effects
of surgical or functional denervation. Vinblastine-block caused up-regulation of 2A isoform
expression in non-tenotomized muscles. The results confirm the essential role played by
neuromotor impulses for type 1 and type 2A isoform expression. They also support the
hypothesis that axoplasmic flow carries some chemical factor inhibiting 2A isoform expression
Giant neuron pathway neurophysiological activity in a per0 mutant of Drosophila melanogaster
No full textIn Drosophila melanogaster, the clock gene period (per) has a clearly defined role in the molecular machinery involved in generating free-running circadian rhythms. per mutations also influence rhythms in the Drosophila love song and in the ultradian timescale. The relationship between these two phenomena has so far escaped satisfactory explanation. Here we analyzed the neurophysiological activity of the giant fiber neural pathway in per(0) flies. Under constant light, and at relatively low stimulation frequencies (1-2 Hz), per(01) flies habituate significantly earlier than they do under 12 h light-dark cycles. The results suggest an involvement of per in phenomena of short-term neural plasticity
The use of osmotic minipumps to block impulse conduction in peripheral nerve and spontaneous activity in denervated skeletal muscle
No full textClustering of cAMP-dependent protein kinase RIalpha during muscle development and regeneration
No full textGiant neuron pathway neurophysiological activity in per0 mutants of Drosophila melanogaster
No full textIn Drosophila melanogaster, the clock gene period (per) has a clearly defined role in the molecular machinery involved in generating free-running circadian rhythms. per mutations also influence rhythms in the Drosophila love song and in the ultradian timescale. The relationship between these two phenomena has so far escaped satisfactory explanation. Here we analyzed the neurophysiological activity of the giant fiber neural pathway in per(0) flies. Under constant light, and at relatively low stimulation frequencies (1-2 Hz), per(01) flies habituate significantly earlier than they do under 12 h light-dark cycles. The results suggest an involvement of per in phenomena of short-term neural plasticity
Slow-to-fast transformation of denervated soleus muscle of the rat, in the presence of an antifibrillatory drug
No full textThe myofibrillar changes of rat denervated soleus muscle were studied in the presence and in the absence of an antifibrillatory drug. After bilateral sciaticotomy, a concentrated solution of procainamide hydrochloride was steadily released, by way of a miniosmotic pump, in the space between the soleus and the gastrocnemius muscles of one leg. Fibrillation activity of soleus muscles was checked electromyografically at 3- to 5-day intervals. On the 21st day following denervation the muscles were excised, stained for adenosine triphosphatase activity and analysed for myosin heavy chain (MHC) isoforms. In the denervated-procainamidetreated muscles fibrillation was consistently (-75% on average) depressed in comparison to the contralateral denervated muscles. Type 1 (slow) fibres and MHC isoform were also significantly reduced, to the advantage of type 2A (fast) fibres and MHC isoform. The results support the view that denervation inactivity, like other kinds of muscle inactivity, favours t..
NMJ transmission and muscle mechanical properties of Drosophila sphingosine-1-phosphate lyase gene (sply) mutants
No full textIF 1.375 GENETICS AND HEREDIT
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