1,721,003 research outputs found
Click chemistry for improving properties of bioresorbable polymers for biomedical applications
No full textIntroduction to soft particles:Fundamentals and perspectives
No full textThe progress of micro- and nanotechnology has led to the formulation of a library of particles at the submicron scale. Some of them have gained great interest due to their dynamic behavior in the operative conditions: colloidal character, stimuli responsiveness, and morphological changes can control the bulk and interfacial behavior with the surrounding environment. Overall, these particles can be identified as soft particles. The opportunity to tune such materials at micro- and nanoscale in obtaining specific properties has prompted researchers to investigate the inner structure of these systems and use them for several purposes, ranging from biomedical to environmental fields. In this chapter, we present an overview of the main types of soft particles and draw attention to their fundamental features and parameters, providing a preliminary guideline for the topics discussed in this book. A brief introduction to the application fields of soft particles is also included.</p
Simple and efficient strategy to synthesize PEG-aldehyde derivatives for hydrazone orthogonal chemistry
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Nanogels Based on Hyaluronic Acid as Potential Active Carriers for Dermatological and Cosmetic Applications
No full textNanogels are a prominent research topic in biomedical and drug delivery applications. The versatility of their chemistry allows them to be tailored both to carry and release a wide range of active molecules, and to target specific tissues or cell types. Within a vast field of possible chemical designs, nanogels based on hyaluronic acid seem particularly interesting from the standpoint of dermatological and cosmetic applications, due to the well-known involvement of hyaluronic acid in several fundamental processes related to skin health and ageing. In spite of this, relatively few studies about these nanocarriers and their potential skin-related benefits have appeared so far in the literature. With the aim to stimulate further interest in the topic, in this review, we provide information on hyaluronic acid-based nanogels, including their key physicochemical properties, their typical drug release behavior, and the main synthetic methodologies. The latter include: approaches based on spontaneous self-assembly of polymer molecules; approaches based on chemical cross-linking, where nanogel formation is promoted by covalent bonds between polymer chains; and hybrid approaches that leverage a combination of the above two mechanisms. We believe this body of information, which we collected by going through the relevant literature from the past 10–15 years, offers cosmetic formulators plenty of options to design innovative products
Hydrogel supported chiral imidazolidinone for organocatalytic enantioselective reduction of olefins in water
No full textSynthesis of novel bio-based and degradable polyurethanes using lignin oligomers
No full textBio-based and degradable materials were proposed to challenge the major problem of plastic disposal in the environment. In this context, polyurethane production was re-evaluated, encouraging the search for replacing both petroleum components and highly toxic species. A novel synthesis route is explored in this work, aimed to produce degradable lignin-based polyurethanes. Oligomers from steam-exploded lignin were extracted and used with e-caprolactone (e-CL) to generate a fully bio-based pre-polymer (oligo-grafted-poly(e-CL)), exploiting ringopening polymerization. We have demonstrated that tuning the main reaction parameters, such as e-CL:oligomer and catalyst:e-CL mass ratios, and reaction time, it is possible to obtain different pre-polymers enabling the synthesis of bio-based polyurethanes with variable physicochemical properties. In particular, the oligomeric content modulates the thermal and mechanical properties of the polymer (melting point range: 54-62 degrees C; Young modulus range: 3-7 kPa) and enhances the degradability (up to 13 % wt, in acid environment), highlighting the potential of the material for possible applications
Microwave-assisted synthesis and click chemistry as simple and efficient strategy for RGD functionalized hydrogels
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