1,354,984 research outputs found
Correction to: Lenvatinib as a salvage therapy for advanced metastatic medullary thyroid cancer (Journal of Endocrinological Investigation, (2021), 44, 10, (2139-2151), 10.1007/s40618-020-01491-3)
No full textThe article “Lenvatinib as a salvage therapy for advanced metastatic medullary thyroid cancer” written by A. Matrone, A. Prete, A. Nervo, A. Ragni, L. Agate, E. Molinaro, C. Giani, L. Valerio, E. Minaldi, A. Piovesan and R. Elise was originally published online on the publisher’s internet portal on 17th February 2021 with Open Access under a Creative Commons Attribution (CC BY) license 4.0 With the authors’ decision to cancel Open Access the copyright of the article changed on 28th April 2021 to © Italian Society of Endocrinology (SIE) 2021 with all rights reserved. The original article has been corrected
Numerical Simulation of Liquid-Structure Interaction Problems in a Tank for Aerospace Applications
No full textMatrone di Pitane. Il banchetto attico
No full textIntroduzione al testo di Matrone di Pitane con discussione dei problemi di traduzione, traduzione del fr. 1 e commento ai luoghi discuss
High-frame-rate coherence imaging of the heart with ultrasound diverging waves
No full textSeveral techniques have been proposed up to now to achieve higher temporal resolution in echocardiography. Among these, the use of diverging beams, which insonify a large region of interest, allows to significantly increase the frame-rate, but at the cost of a reduced signal-to-noise ratio. For this reason, in this paper we propose to combine high-frame-rate imaging, by transmitting diverging waves (DWs), to the Short-Lag Spatial Coherence (SLSC) technique in reception, which provides images of the coherence of backscattered echoes and is known to yield improved contrast in scenarios with high-clutter. We test this combined method first on phantom acquisitions and then on in vivo cardiac scans, i.e. on apical views of the heart. Results show that SLSC can provide improved contrast ratio (CR) and generalized contrast-to-noise ratio (GCNR) with respect to the classic Delay and Sum (DAS) as the number of transmitted DWs increases, particularly when clutter is present. Indeed, cardiac images show improved apex visibility and artifact suppression in the heart chambers with SLSC, achieving high contrast and high frame-rate at the same time
Numerical Simulation of Liquid-structure Interaction Problem in a Tank of a Space Re-entry Vehicle
No full textNon
State of the Art in 3D Culture Models Applied to Thyroid Cancer
No full textThyroid cancer (TC) is the prevalent endocrine tumor with a rising incidence, particularly in higher-income countries, leading to an increased interest in its management and treatment. While overall, survival rates for TC are usually favorable, advanced cases, especially with metastasis and specific histotypes, pose challenges with poorer outcomes, advocating the need of systemic treatments. Targeted therapies have shown efficacy in both preclinical models and clinical trials but face issues of resistance, since they usually induce partial and transient response. These resistance phenomena are currently only partially addressed by traditional preclinical models. This review explores the limitations of traditional preclinical models and emphasizes the potential of three-dimensional (3D) models, such as transwell assays, spheroids, organoids, and organ-on-chip technology in providing a more comprehensive understanding of TC pathogenesis and treatment responses. We reviewed their use in the TC field, highlighting how they can produce new interesting insights. Finally, the advent of organ-on-chip technology is currently revolutionizing preclinical research, offering dynamic, multi-cellular systems that replicate the complexity of human organs and cancer-host interactions
DATA INTEGRATION OF PHOTOGRAMMETRIC AND LASER-VISUAL-INERTIAL ODOMETRY BASED SENSORS IN THE METRIC SURVEY OF CULTURAL HERITAGE
No full textRecent developments in the metric survey methods and techniques in the field of Geomatics are increasingly favouring the integration of data obtained from different sensors. Range-based techniques on one hand and image-based techniques on the other are complementary whenever a specific metric documentation is required, with high level of detail and accuracy. Over the last years, there has been a consolidation of the SLAM (Simultaneous Localization and Mapping) technology and its growing diffusion. With the aim of evaluating strengths and weaknesses of systems that use this technology, this contribution intends to compare some acquired datasets, with different modalities and sensors, in a context of rapid mapping of cultural assets. Specifically, the laser-visual-inertial odometry platform Kaarta STENCIL was tested and its products were compared with those obtained a terrestrial laser scanner, used as a ground truth. Furthermore, given the limitations of range-based systems in the acquisition of radiometric data of reasonable quality, suitable for texturing processes, the data obtained from the STENCIL Kaarta have been integrated with those acquired by terrestrial and aerial photogrammetry: this has allowed to associate the photogrammetric radiometric component to the geometric one acquired by the Kaarta system. It has therefore been shown that an integration of image-based technologies with range-based technologies is an effective compromise between acquisition time and quality of the generated 3D products; the possibility offered by the employed devices and technologies allow to obtain, within a rapid mapping approach, suitable data for the documentation and the study of cultural heritage
High-level-of-detail semantic 3D GIS for risk and damage representation of architectural heritage
No full textThe need to share information about architectural heritage effectively after a disaster event, in order to foster its preservation, requires the use of a common language between the involved actors and stakeholders. A database able to connect the architectural heritage representation with the data useful for hazard and risk analysis can thus be a powerful instrument. This paper outlines a methodology to represent 3D models of the architectural heritage, according to some existing standards data models, and relate their geometric features to the damage mechanisms that could occur after an earthquake. Among all the existing standard to represent cartographic, cultural heritage and hazard/risk information, respectively INSPIRE, CityGML, UNESCO, CIDOC-CRM, its extension MONDIS and the Getty Institute vocabularies, compliant to the CIDOC-CRM, have been taken into account. An INSPIRE extension has been proposed for increasing the level of detail (LoD) of the representation and improving the description of heritage buildings, adding some macro-elements and elements “feature types” connected with the damage mechanisms, identified in structural studies. The suggested method allows to archive, in a multi-scale database, 3D information with a very high level of detail about architectural heritage and can help structural engineers and conservator-restorers in preventing further damages through individuating useful targeted actions.Urban Data Scienc
La voce e il silenzio: il dissenso delle matrone al tramonto della Repubblica.
No full textIl contributo indaga le diverse modalità comunicative attivate dalle matrone romane, in ottemperanza o in violazione del mos maiorum, nella tarda repubblica romana e l'utilizzo delle stesse come strumento di dissenso, in un periodo che, connotato da tratti di eccezionalità per il perdurare delle guerre civili, consentì alle donne romane spazi di azione pubblica e politica in precedenza loro esclusi
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