1,720,983 research outputs found
Topical diclofenac 3% gel plus cryotherapy for treatment of multiple and recurrent actinic keratoses.
No full textSympathetic nervous system dysfunction: a common pathway linking skin and heart morbidity?
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Topical immunotherapy with squaric acid dibutylester: unusual hair pigmentary changes in two cases of alopecia areata.
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A fractal analysis of skin pigmented lesions using the novel tool of the variogramm technique
No full textThe incidence of the cutaneous malignant melanoma is increasing rapidly in the world [Ferlay J, Bray F, Pisani P,
et al. GLOBOCAN 2000: Cancer incidence, mortality and prevalence worldwide, Version 1.0 IARC Cancer Base no. 5.
Lyon: IARC Press, 2001]. The therapeutic address requires a method having high sensitivity and capability to diagnose
such disease at an early stage. We introduce a new diagnostic method based on non-linear methodologies. In detail we
suggest that fractal as well as noise and chaos dynamics are the most important components responsible for genetic
instability of melanocytes. As consequence we introduce the new technique of the variogram and of fractal analysis
extended to the whole regions of interest of skin in order to obtain parameters able to identify the malignant lesion.
In a preliminary analysis, satisfactory results are reached
Cardiovascular Reactivity to experimental stress in Psoriasis: a controlled Investigation
No full textA defective response of psoriatic skin to β-adrenergic
stimulation has been implicated in the pathophysiology
of psoriasis. A psychophysiological study was planned
to investigate whether the β-adrenergic receptor hyporesponsiveness
found in psoriatic skin can also be detected
in other systems. Twenty-five psoriatic patients and
50 healthy controls were submitted to a standardized
stressful procedure (mental arithmetic and the Stroop
Colour-Word Naming Test) to trigger the activation
of the sympathetic nervous system, and their haemodynamic
responses were compared. While there were no
differences between groups in perceived stress, a blunted
increase in heart rate and a sharper increase in diastolic
blood pressure was observed in psoriasis patients compared
with controls. The psychophysiological reaction
pattern observed in psoriatic patients might be explained
by lower reactivity of heart β1-adrenergic receptors
and arteriolar walls β2-adrenergic receptors. While this
study suggests that β-adrenergic receptor hyporesponsiveness
might have a systemic expression in psoriatic
patients, it needs support from future studies exploring
β-adrenergic function in psoriatic patients more directly.
Key words: psoriasis; stress; heart rate; blood pressure;
sympathetic nervous system; beta-adrenergic receptor
Seborrhoeic dermatitis in the elderly: inferences on the possible role of disability and loss of self-sufficiency
No full textThe constant increase of life expectancy in countries with
high standards of living raises growing concern about
many aspects of skin morbidity in the elderly. ,4.s regards
seborrhoeic dermatifis, literature yields prevalence esfimates
for elderly people that are eonsistently higher than
those reported from the general populafion. This prompts
speculations on wheÉher factors inherently involved in
senescence might have some role in the course of
seborrhoeic dermafitis. In a series of 186 subiects, aged
>65, strength of association of the skin disorder with
ege, sex, coexisting non-cutanecus conditions, and degree
of loss of self-sufficiency in activities of daily living {ADL
index) was evaluafed by univariate and multivariate
analysis. We found that age (OR: 1.14; p<0.001) and,
more importantly, dcpendency in more than one ADL
(OR: 30.2; p<0.0ù01) were independent explanatory
variables of seborrhoeic dermatitis. These findings
suggest that s€nescenc€ per se might have some
significance in the natural history of this type of
eczema. Key v,ords: sehorrhoeic dermatitis; old age;
senescence; tlisahility; ADL index; oùls vart
Seborrheic dermatitis, increased sebum excretion, and Parkinson's disease: a survey of (im)possible links
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