1,720,986 research outputs found
Studio d’ interazione dell’ epitopo g(312-324) della fibrina umana con ligandi peptidici
No full textDevelopment of QSAR models for predicting inhibition of tubulin polymerization in the design of anticancer drugs
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Theoretical Studies of Interactions between Chelidocystatin and human Cathepsins for potential applications in cancer therapy
No full textSTUDI TEORICI D’INTERAZIONE TRA NUOVI COMPOSTI E CATEPSINA L UMANA PER POTENZIALI APPLICAZIONI NELLA TERAPIA ONCOLOGICA
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HIGH-THROUGHPUT DOCKING AS A TOOL FOR VIRTUAL SCREENING AND FLUORIMETRIC ASSAYS AIMED AT IDENTIFYING FIBRIN LIGANDS
No full textThree-dimensional models of the oligomeric human Asialoglycoprotein Receptor (ASGP-R)
No full textThe work presented here is aimed at suggesting plausible hypotheses for functional oligomeric forms of the human asialoglycoprotein receptor (ASGP-R), by applying a combination of different computational techniques. The functional ASGP-R is a hetero-oligomer, that comprises of several subunits of two different kinds (H1 and H2), which are highly homologous. Its stoichiometry is still unknown. An articulated step-wise modeling protocol was used in order to build the receptor model in a minimal oligomeric form, necessary for it to bind multi-antennary carbohydrate ligands. The ultimate target of the study is to contribute to increasing the knowledge of interactions between the human ASGP-R and carbohydrate ligands, at the molecular level, pertinent to applications in the field of hepatic tissue engineering
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