1,720,994 research outputs found
Tridentate N-N-N chelating systems as potential antitumor agents [Sistemi chelanti tridentati N*-N*-N* quali potenziali agenti antitumorali]
No full textTridentate chelating agents, as potential antitumor agents, were prepared by condensing 2-quinolylhydrazines, 2-pyridylhydrazine and 2-benzothiazolylhydrazine with pyridine-2-aldehyde, 6-methylpyridine-2-aldehyde, 2-acetylpyridine and 2-benzoylpyridine. All compounds were tested against Lymphocytic leukemia P388. The active pyridine-2-aldehyde-4-methyl-2-quinolylhydrazone [1-(4'-methyl-2'-quinolyl)-3-(2'-pyridyl)-1,2-diaza-2-propene] (I d) was also tested against other experimental tumors and proved inactive
Anti-inflammatory and analgesic effects of Spartium junceum L. flower extracts. A preliminary study
No full textPreliminary studies on anti-inflammatory and analgesic activities of Salpichroa rhomboidea Miers extract
No full textSynthesis and beta1-, beta2-adrenergic receptor binding studies of 4-acylamino substituted phenoxypropanolamine and 5-acylamino substituted naphthyloxypropanolamine derivatives
No full textThe object of this study was to Investigate the beta-adrenergic receptor binding affinity of 4-acylaminophenoxypropanolamine (10-15) and 5-acylaminonaphthyloxypropanolamine (21-24) derivatives, which were prepared from 4-aminophenol (5) and 5-amino-1-naphthol (16), respectively. The in vitro beta(1)- and beta(2)-adrenergic receptor binding affinities of the newly synthesized compounds were assessed in turkey erythrocyte membrane (beta(1)) and lung homogenates of rats (beta(2)). The binding affinities were compared with that of propranolol (3) (propranolol hydrochloride, CAS 318-98-9). The compound N-[5-(3-tert-butylamino-2-hydroxy-propoxy)-naphthalen-1-yl]- acetamide (22) has beta-adrenergic receptor affinity comparable with that of propranolol and shows selectivity to beta(1)-adrenergic receptor
Preliminary studies on anti-inflammatory and analgesic activities of Salpichroa rhomboidea Miers extract.
No full textAttività antiproliferativa di estratti di fusti e radici di Cucurbita ficifolia Bouché
No full textPreliminary evaluation on anti-inflammatory and analgesic effects of Sideritis syriaca L. herba extracts
No full textGel di Aloe vera (L.) Burm.f. Determinazione del contenuto di aloina in prodotti commerciali per uso interno.
No full textPreliminary studies on anti-inflammatory and analgesic activities of Salpichroa rhomboidea Miers extract
No full textObjective: To study the anti-inflammatory and analgesic activity of a fraction obtained from the ethanolic extract of Salpichroa rhomboidea Miers aerial parts. Material and methods: Wild samples of Salpichroa rhomboidea Miers plants were collected at the flowering stage, powdered and then extracted with ethanol. The alcohol extract was partitioned by liquid-liquid chromatography and the fractions obtained evaporated to dryness. The residues were suspended and tested for anti-inflammatory activity in carrageenin rat paw oedema test, and for analgesic activity in Randall and Selitto test and in Tail-flick test. 24 h after the treatment, the gastric mucosa of each rat was observed macroscopically. Result: Results show interesting peripheral analgesic activity and good central analgesic activity but a lack of anti-inflammatory activity for Salpichroa extract. In rats treated with the tested compounds hyperaemia and ulcers were absent. Conclusion: This preliminary study shows the potential of Salpichroa extract, due to marked analgesic activity and the absence of gastric ulcerogenic activity
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