1,721,349 research outputs found
Dysphagia in neurological diseases: a literature review. Panebianco M, Marchese-Ragona R, Masiero S, Restivo DA. Neurol Sci. 2020 Jun 7. doi: 10.1007/s10072-020-04495-2.
Full text linkDysphagia is defined as an impairment of this complex and integrated sensorimotor system. It is estimated that 400,000 to 800,000 individuals worldwide develop neurogenic dysphagia per year. Neurogenic dysphagia is typically occurring in patients with neurological disease of different etiologies. A correct and early diagnosis and an appropriate management of dysphagia could be useful for improving patient’s quality of life and may help to prevent or delay death. In the present review, we discuss thoroughly the anatomy and physiology of swallowing and also the pathophysiological mechanisms involved in impaired swallowing, as well as the diagnosis, management, and potential treatments of neurogenic dysphagia. Assessment of neurogenic dysphagia includes medical history, physical exam, and instrumental examinations (fiberoptic endoscopic evaluation of swallowing, videofluoroscopic swallowing study, electromyography). Pharmacological treatment of these problems includes oral anticholinergic drugs. Surgical myotomy of the cricopharyngeal muscle showed an important improvement of oropharyngeal dysphagia associated to upper esophageal sphincter hyperactivity. Chemical myotomy of the upper esophageal sphincter by local injections of botulinum toxin type A into the cricopharyngeal muscle has been proposed as an alternative less invasive and less unsafe than surgical myotomy
Oropharyngeal dysphagia as a geriatric syndrome
No full textOropharyngeal dysphagia fulfils all the criteria proposed for geriatric syndromes: high prevalence in older persons at different settings, combination of various symptoms, interaction and common risk factors with other geriatric syndromes such as older age, cognitive and functional impairment, association with impaired clinical outcomes, and need of a multicomponent intervention, as it is shown in this chapter with a summary of current evidence
The use of CD spectroscopy for the study of the self-assembly of guanine derivatives
No full textCircular dichroism (CD) spectroscopy can be successfully used to study the assembly of homoguanylic and guanosine-rich oligonucleotides. The CD corresponding to the low-energy bands of the guanine spectrum in the 250-290 nm region is mainly determined by exciton interaction between the guanine chromophores; it gives information on the relative skew of G-quartets and on their distortion from the classical structure found in the four-stranded helix of poly(G). The handedness of the sugar-phosphate backbone can be deduced indirectly only if the conformation of the bases around the glycosyl bond is known
Self-assembly in organic solvents of a deoxyguanosine derivative induced by alkali metal picrates
No full text3′,5′-Didecanoyl-2′-deoxyguanosine in chlorinated organic solvents undergoes self-assembly mediated by alkali metal picrates which leads to octameric or polymeric species according to the amount of ions present
Stereochemistry of protiodesilylation of 3-trimethylsilyl-2-thiabicyclo[2.2.1]heptenes, heptanes and derivatives
No full textSome 3-trimethylsilyl-2-thiabicyclo[2.2.1]heptenes and heptanes of known configuration were protiodesilylated and the stereochemistry of the reaction was studied. Evidences for a carbanionic intermediate as well as the pivotal role played by the metal counter-ion are described. © 1994, Taylor & Francis Group, LLC. All rights reserved
Botulinum toxin versus fascial manipulation technique in the treatment of chronic facial pain.
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Health resort medicine can be a suitable setting to recover disabilities in patients tested negative for COVID-19 discharged from hospital? A challenge for the future
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